PHEX

Description		phosphate regulating endopeptidase X-linked
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Skeletal System Development Proteolysis Cell-cell Signaling Protein Processing Organophosphate Metabolic Process Bone Mineralization Lung Development Biomineral Tissue Development Response To Vitamin D Protein Modification Process Odontogenesis Bone Development Response To Growth Hormone Cellular Response To Vitamin D Cellular Response To Parathyroid Hormone Stimulus Response To Sodium Phosphate Response To Insulin-like Growth Factor Stimulus
Pathways
Drugs
Diseases		Hypophosphatemic rickets; X-Linked dominant hypophosphatemia (XLH); Autosomal dominant hypophosphatemic rickets (ADHR); Autosomal recessive hypophosphatemic rickets (ARHR); Hereditary hypophophatemic rickets with hypercalciuria (HHRH)
GWAS		Anger ( 24489884) F-cell distribution in sickle cell anaemia ( 21326311) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Phosphorus levels ( 29403010) Tourette syndrome ( 22889924)
Interacting Genes		1 interacting genes: FGF23
Entrez ID		5251
HPRD ID		02387
Ensembl ID		ENSG00000102174
Uniprot IDs		B4DNS0 B4DWG8 P78562
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Magnesium Ion Vitamin D Metabolic Process Cellular Response To Leptin Stimulus Response To Leptin Cellular Response To Vitamin D Positive Regulation Of Vitamin D 24-hydroxylase Activity Cellular Response To Parathyroid Hormone Stimulus Vitamin D Catabolic Process Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Phosphate Transport Negative Regulation Of Bone Mineralization Response To Parathyroid Hormone Response To Sodium Phosphate Intracellular Phosphate Ion Homeostasis Phosphate Ion Homeostasis Cellular Response To Interleukin-6 Regulation Of Oxidoreductase Activity Type 1 Fibroblast Growth Factor Receptor Binding Response To Interleukin-6 Fibroblast Growth Factor Receptor Binding Steroid Catabolic Process Response To Salt Vitamin Metabolic Process Response To Vitamin D Negative Regulation Of Biomineral Tissue Development Cellular Response To Nutrient Negative Regulation Of Ossification ERK1 And ERK2 Cascade Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Hormone Secretion Response To Vitamin Regulation Of Bone Mineralization Golgi Lumen Neurogenesis Regulation Of Ossification Regulation Of Osteoblast Differentiation Negative Regulation Of Secretion By Cell Response To Nutrient Growth Factor Activity Negative Regulation Of Secretion Positive Regulation Of ERK1 And ERK2 Cascade Calcium Ion Homeostasis Steroid Metabolic Process MAPK Cascade Regulation Of Hormone Secretion Cellular Response To Nutrient Levels Lipid Catabolic Process
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