PHEX

Gene Name		phosphate regulating endopeptidase homolog, X-linked
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Aminopeptidase Activity Metalloendopeptidase Activity Zinc Ion Binding
	Biological Process	Skeletal System Development Cellular Protein Modification Process Proteolysis Cell-cell Signaling Organophosphate Metabolic Process Bone Mineralization
Pathways
Drugs
Diseases
GWAS		F-cell distribution ( 21326311) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Tourette syndrome ( 22889924)
Protein-protein Interactions		1 interactors: FGF23
Entrez ID		5251
HPRD ID		02387
Ensembl ID		ENSG00000102174
Uniprot IDs		B4E334 P78562
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Vitamin D 24-hydroxylase Activity Vitamin D Catabolic Process Cellular Phosphate Ion Homeostasis Regulation Of Phosphate Transport Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Vitamin D Metabolic Process Phosphate Ion Homeostasis Negative Regulation Of Bone Mineralization Negative Regulation Of Biomineral Tissue Development Steroid Catabolic Process Positive Regulation Of Oxidoreductase Activity Anion Homeostasis Negative Regulation Of Osteoblast Differentiation Alcohol Catabolic Process Negative Regulation Of Hormone Secretion Regulation Of Bone Mineralization Regulation Of Oxidoreductase Activity Negative Regulation Of Ossification Vitamin Metabolic Process Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Osteoblast Differentiation Phosphatidylinositol-mediated Signaling Regulation Of Anion Transport Insulin Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Secretion By Cell ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Secretion Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Response To Fibroblast Growth Factor Regulation Of Ossification Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Lipid Catabolic Process Steroid Metabolic Process Regulation Of Hormone Secretion Fc Receptor Signaling Pathway Response To Insulin Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Alcohol Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Transport
Tagcloud ?		cko conditionally crossing demonstrable dentin dmp1 endopeptidase fgf fgf2 fgf23 fgfr fgfr1 fgfr1dmp1 fgfr1flox fgfr1null fibroblastic flox hyp hypophosphatemia mepe osteocytes osteomalacia paracrine phosphoglycoprotein plcgamma rickets sclerostin sost xlh