PHEX and FGF23

Number of citations of the paper that reports this interaction (PMID 11409890)
40

Data Source:
HPRD (in vitro)

		PHEX	FGF23
Gene Name		phosphate regulating endopeptidase homolog, X-linked	fibroblast growth factor 23
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Perinuclear Region Of Cytoplasm	Extracellular Region Extracellular Space
	Molecular Function	Aminopeptidase Activity Metalloendopeptidase Activity Zinc Ion Binding	Type 1 Fibroblast Growth Factor Receptor Binding Growth Factor Activity
	Biological Process	Skeletal System Development Cellular Protein Modification Process Proteolysis Cell-cell Signaling Organophosphate Metabolic Process Bone Mineralization	Phosphate-containing Compound Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Phosphate Transport Positive Regulation Of Vitamin D 24-hydroxylase Activity Cell Differentiation Negative Regulation Of Bone Mineralization Cellular Phosphate Ion Homeostasis Fc-epsilon Receptor Signaling Pathway Vitamin D Catabolic Process Innate Immune Response Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Hormone Secretion Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Phosphate Ion Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway
Pathways			Signaling by the B Cell Receptor (BCR) Phospholipase C-mediated cascade Signaling by FGFR in disease SHC-mediated cascade Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Signaling by FGFR2 mutants DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade Signaling by activated point mutants of FGFR1 Signaling by FGFR1 mutants PI3K Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer Activated point mutants of FGFR2 PI3K events in ERBB4 signaling Signaling by ERBB2 FGFR4 ligand binding and activation Signaling by EGFR Signaling by FGFR3 mutants Downstream signal transduction Signaling by activated point mutants of FGFR3 Fc epsilon receptor (FCERI) signaling Signaling by FGFR mutants Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling Downstream signaling of activated FGFR FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR1c and Klotho ligand binding and activation FGFR2c ligand binding and activation FGFR ligand binding and activation Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane FGFR3 ligand binding and activation Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR Klotho-mediated ligand binding FGFR2 ligand binding and activation FRS2-mediated cascade IRS-mediated signalling FGFR1 ligand binding and activation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade
Drugs
Diseases
GWAS		F-cell distribution ( 21326311) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Tourette syndrome ( 22889924)	Colorectal cancer ( 23263487) Phosphorus levels ( 20558539)
Protein-Protein Interactions		1 interactors: FGF23	3 interactors: FGFR2 FGFR3 PHEX
Entrez ID		5251	8074
HPRD ID		02387	05648
Ensembl ID		ENSG00000102174	ENSG00000118972
Uniprot IDs		B4E334 P78562	Q9GZV9
PDB IDs			2P39
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Vitamin D 24-hydroxylase Activity Vitamin D Catabolic Process Cellular Phosphate Ion Homeostasis Regulation Of Phosphate Transport Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Vitamin D Metabolic Process Phosphate Ion Homeostasis Negative Regulation Of Bone Mineralization Negative Regulation Of Biomineral Tissue Development Steroid Catabolic Process Positive Regulation Of Oxidoreductase Activity Anion Homeostasis Negative Regulation Of Osteoblast Differentiation Alcohol Catabolic Process Negative Regulation Of Hormone Secretion Regulation Of Bone Mineralization Regulation Of Oxidoreductase Activity Negative Regulation Of Ossification Vitamin Metabolic Process Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Osteoblast Differentiation Phosphatidylinositol-mediated Signaling Regulation Of Anion Transport Insulin Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Secretion By Cell ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Secretion Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Response To Fibroblast Growth Factor Regulation Of Ossification Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Lipid Catabolic Process Steroid Metabolic Process Regulation Of Hormone Secretion Fc Receptor Signaling Pathway Response To Insulin Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Alcohol Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Transport	Bone Mineralization Biomineral Tissue Development Ossification Lens Fiber Cell Development Lens Fiber Cell Differentiation Negative Regulation Of Mitotic Nuclear Division Skeletal System Development Lung Alveolus Development Digestive Tract Morphogenesis Positive Regulation Of Phospholipase Activity Negative Regulation Of Cell Division Midbrain Development Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Smoothened Signaling Pathway Lens Development In Camera-type Eye Organ Growth Cell-cell Signaling Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Mitotic Nuclear Division Bone Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Epithelial Cell Proliferation Phosphatidylinositol-mediated Signaling Digestive Tract Development Developmental Growth Involved In Morphogenesis Insulin Receptor Signaling Pathway Digestive System Development Coronal Suture Morphogenesis Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Involved In Positive Regulation Of Cell Proliferation In Bone Marrow Fibroblast Growth Factor Receptor Signaling Pathway Involved In Hemopoiesis Fibroblast Growth Factor Receptor Signaling Pathway Involved In Negative Regulation Of Apoptotic Process In Bone Marrow Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Wnt Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Inner Ear Development Regulation Of ERK1 And ERK2 Cascade Epithelial Cell Development Negative Regulation Of Apoptotic Process In Bone Marrow Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Negative Regulation Of Mitotic Cell Cycle Neurotrophin Signaling Pathway
Tagcloud ?		cko conditionally crossing demonstrable dentin dmp1 endopeptidase fgf fgf2 fgf23 fgfr fgfr1 fgfr1dmp1 fgfr1flox fgfr1null fibroblastic flox hyp hypophosphatemia mepe osteocytes osteomalacia paracrine phosphoglycoprotein plcgamma rickets sclerostin sost xlh	aging camp clearly cleavage closely deficiency encodes extends importantly intracellular klotho lifespan longevity overexpression p21 participate participates pkc premature reasons secreted shows summarize suppresses suppressor tgf transforming transmembrane wnt
Tagcloud (Difference) ?		cko conditionally crossing demonstrable dentin dmp1 endopeptidase fgf fgf2 fgfr fgfr1 fgfr1dmp1 fgfr1flox fgfr1null fibroblastic flox hyp hypophosphatemia mepe osteocytes osteomalacia paracrine phosphoglycoprotein plcgamma rickets sclerostin sost xlh	aging camp clearly cleavage closely deficiency encodes extends importantly intracellular klotho lifespan longevity overexpression p21 participate participates pkc premature reasons secreted shows summarize suppresses suppressor tgf transforming transmembrane wnt
Tagcloud (Intersection) ?		fgf23