GRPEL1 and SFTPB

		GRPEL1	SFTPB
Description		GrpE like 1, mitochondrial	surfactant protein B
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GO Annotations	Cellular Component	PAM Complex, Tim23 Associated Import Motor Nucleoplasm Mitochondrion Mitochondrial Inner Membrane TIM23 Mitochondrial Import Inner Membrane Translocase Complex Mitochondrial Matrix	Extracellular Region Extracellular Space Cytoplasm Lysosome Multivesicular Body Endoplasmic Reticulum Membrane Lamellar Body Clathrin-coated Endocytic Vesicle Alveolar Lamellar Body Multivesicular Body Lumen
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Unfolded Protein Binding Protein-folding Chaperone Binding	Protein Binding
	Biological Process	Protein Folding Intracellular Protein Transport Protein Import Into Mitochondrial Matrix	Lipid Metabolic Process Sphingolipid Metabolic Process Respiratory Gaseous Exchange By Respiratory System Animal Organ Morphogenesis
Pathways		Mitochondrial protein import	Surfactant metabolism Defective pro-SFTPB causes SMDP1 and RDS Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4
Drugs
Diseases			Pulmonary surfactant metabolism dysfunction (SMDP)
GWAS		Eosinophil percentage of white cells ( 32888494)	Blood protein levels ( 30072576)
Interacting Genes		7 interacting genes: CCDC57 ERCC6 GALT ISG15 POLR1C SPG21 WBP2	2 interacting genes: CTSH MEOX2
Entrez ID		80273	6439
HPRD ID		07550	01523
Ensembl ID		ENSG00000109519	ENSG00000168878
Uniprot IDs		Q9HAV7	P07988
PDB IDs		9BLS 9BLT 9BLU	1DFW 1KMR 1RG3 1RG4 1SSZ 2DWF 2JOU 2M0H 2M1T
Enriched GO Terms of Interacting Partners?			Kininogen Binding HLA-A Specific Activating MHC Class I Receptor Activity Bradykinin Catabolic Process Neuropeptide Catabolic Process Alveolar Lamellar Body Outer Dense Fiber Response To Odorant Peptidase Activator Activity Involved In Apoptotic Process Multivesicular Body Lumen Thyroid Hormone Binding Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Somite Specification PAM Complex, Tim23 Associated Import Motor Lysosomal Protein Catabolic Process Cellular Response To Thyroid Hormone Stimulus Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Protein Catabolic Process In The Vacuole Segment Specification Somite Development TIM23 Mitochondrial Import Inner Membrane Translocase Complex Adenyl-nucleotide Exchange Factor Activity Peptide Catabolic Process Surfactant Homeostasis T Cell Mediated Cytotoxicity Response To Thyroid Hormone Protein Import Into Mitochondrial Matrix Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Aminopeptidase Activity T Cell Mediated Immunity Membrane Protein Proteolysis Metanephros Development Zymogen Activation Protein Localization To Mitochondrion
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