TM2D3 and SELENOS

		TM2D3	SELENOS
Description		TM2 domain containing 3	selenoprotein S
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytoplasmic Microtubule Plasma Membrane Membrane Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Derlin-1-VIMP Complex Derlin-1 Retrotranslocation Complex
	Molecular Function		Protein Binding Antioxidant Activity Enzyme Binding Signaling Receptor Activity ATPase Binding Ubiquitin-specific Protease Binding
	Biological Process	Positive Regulation Of Notch Signaling Pathway Lateral Inhibition	Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Gluconeogenesis Intracellular Protein Transport ER Overload Response Response To Glucose Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Cellular Response To Insulin Stimulus Cellular Response To Oxidative Stress ERAD Pathway Establishment Of Protein Localization Cell Redox Homeostasis Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of D-glucose Import Negative Regulation Of Inflammatory Response Response To Redox State Cellular Response To Lipopolysaccharide Regulation Of Nitric Oxide Metabolic Process Cellular Oxidant Detoxification Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Macrophage Apoptotic Process
Pathways			E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Depression in multiple sclerosis (pre-diagnosis) ( 33296963) Triglyceride levels ( 32154731)
Interacting Genes		3 interacting genes: ERRFI1 LCOR PAXIP1	9 interacting genes: APOA5 DERL1 GTF2IRD1 KLHDC2 KPNB1 MFHAS1 SAA1 SRPK2 VCP
Entrez ID		80213	55829
HPRD ID		16554	12133
Ensembl ID		ENSG00000184277	ENSG00000131871
Uniprot IDs		B4DLL2 E7EPS7 H0YNS4 Q9BRN9	Q6GYA4 Q9BQE4
PDB IDs			2Q2F 5KIU 5KIY 6DO4
Enriched GO Terms of Interacting Partners?		Ubiquitin-specific Protease Binding Adipose Tissue Development Connective Tissue Development Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Cellular Response To Lipid Response To Estradiol Cellular Response To Insulin Stimulus Uterine Epithelium Development Response To 1-oleoyl-sn-glycerol 3-phosphate Derlin-1-VIMP Complex Intracellular Signal Transduction Chorion Development Negative Regulation Of Protein Autophosphorylation Anatomical Structure Homeostasis Tissue Homeostasis Cellular Response To Peptide Hormone Stimulus Oviduct Epithelium Development Regulation Of Tumor Necrosis Factor Production Response To Insulin Threonine-tRNA Ligase Activity Threonyl-tRNA Aminoacylation Response To Lipid Limb Joint Morphogenesis Cellular Response To Oxygen-containing Compound Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Negative Regulation Of Macrophage Apoptotic Process Osteoclast Development MLL3/4 Complex Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Chondrocyte Proliferation Negative Regulation Of Collagen Biosynthetic Process Skin Morphogenesis Negative Regulation Of Signaling Receptor Activity Lung Vasculature Development Negative Regulation Of Cytokine Production Response To Peptide Hormone Fat Pad Development Progesterone Receptor Signaling Pathway Regulation Of Type B Pancreatic Cell Proliferation Lung Epithelium Development Cellular Response To Chemical Stress Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Protein Tyrosine Kinase Activity Regulation Of Protein Autophosphorylation Cellular Response To Hormone Stimulus ER Overload Response Negative Regulation Of Acute Inflammatory Response	Ubiquitin Protein Ligase Binding Spliceosomal Complex Assembly Derlin-1 Retrotranslocation Complex Cellular Response To Misfolded Protein Response To Misfolded Protein Protein-RNA Complex Assembly Retrograde Protein Transport, ER To Cytosol MHC Class I Protein Binding Ubiquitin-specific Protease Binding High-density Lipoprotein Particle Regulation Of MRNA Splicing, Via Spliceosome Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of MRNA Splicing, Via Spliceosome Cellular Response To Topologically Incorrect Protein
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