MINDY3 and TRIM49

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (two hybrid, affinity chromatography technology)

		MINDY3	TRIM49
Name		MINDY lysine 48 deubiquitinase 3	tripartite motif containing 49
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Membrane	Cytoplasm
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity K48-linked Deubiquitinase Activity	Protein Binding Zinc Ion Binding Protein Kinase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Proteolysis Apoptotic Process Protein K48-linked Deubiquitination	Regulation Of Gene Expression Innate Immune Response
GWAS		No GWAS studies recorded	Intraocular pressure ( 30591961 ) Response to taxane treatment (docetaxel) ( 23006423 ) Serum metabolite levels ( 33031748 )
Interacting Genes		10 interacting genes: DAZAP2 MAP3K1 RAD23A RPL8 SDCBP SMURF1 TRIM49 TRIM49C UBC WEE2-AS1	4 interacting genes: BLM LGALS8 MINDY3 POM121
Entrez ID		80013	57093
HPRD ID		10702	05840
Ensembl ID		ENSG00000148481	ENSG00000168930
Uniprot IDs		Q9H8M7	E9PK69 P0CI25
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		None	8-hydroxy-2'-deoxyguanosine DNA Binding DNA Geometric Change Forked DNA-dependent Helicase Activity Resolution Of DNA Recombination Intermediates Telomeric G-quadruplex DNA Binding DNA/DNA Annealing Activity RecQ Family Helicase-topoisomerase III Complex Telomeric D-loop Binding Four-way Junction Helicase Activity Telomeric D-loop Disassembly Cellular Response To Camptothecin Bubble DNA Binding Y-form DNA Binding G-quadruplex DNA Binding Telomere Maintenance Via Semi-conservative Replication Lymphatic Endothelial Cell Migration Xenophagy Plasma Cell Differentiation Nuclear Membrane T-circle Formation Cellular Response To Hydroxyurea Response To Hydroxyurea Telomeric Loop Disassembly Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides 3'-5' DNA Helicase Activity Lateral Element Negative Regulation Of Cell Division Four-way Junction DNA Binding DNA Conformation Change K48-linked Deubiquitinase Activity Structural Constituent Of Nuclear Pore Nuclear Localization Sequence Binding DNA Double-strand Break Processing