MINDY3 and TRIM49

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		MINDY3	TRIM49
Description		MINDY lysine 48 deubiquitinase 3	tripartite motif containing 49
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Membrane	Cytoplasm
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity K48-linked Deubiquitinase Activity	Protein Binding Zinc Ion Binding Protein Kinase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Proteolysis Apoptotic Process Protein K48-linked Deubiquitination	Regulation Of Gene Expression Innate Immune Response
Pathways
Drugs
Diseases
GWAS			Intraocular pressure ( 30591961) Response to taxane treatment (docetaxel) ( 23006423) Serum metabolite levels ( 33031748)
Interacting Genes		10 interacting genes: DAZAP2 MAP3K1 RAD23A RPL8 SDCBP SMURF1 TRIM49 TRIM49C UBC WEE2-AS1	4 interacting genes: BLM LGALS8 MINDY3 POM121
Entrez ID		80013	57093
HPRD ID		10702	05840
Ensembl ID		ENSG00000148481	ENSG00000168930
Uniprot IDs		Q9H8M7	E9PK69 P0CI25
PDB IDs
Enriched GO Terms of Interacting Partners?			8-hydroxy-2'-deoxyguanosine DNA Binding DNA Geometric Change Forked DNA-dependent Helicase Activity Resolution Of DNA Recombination Intermediates Telomeric G-quadruplex DNA Binding DNA/DNA Annealing Activity RecQ Family Helicase-topoisomerase III Complex Telomeric D-loop Binding Four-way Junction Helicase Activity Telomeric D-loop Disassembly Cellular Response To Camptothecin Bubble DNA Binding Y-form DNA Binding G-quadruplex DNA Binding Telomere Maintenance Via Semi-conservative Replication Lymphatic Endothelial Cell Migration Xenophagy Plasma Cell Differentiation Nuclear Membrane T-circle Formation Cellular Response To Hydroxyurea Response To Hydroxyurea Telomeric Loop Disassembly Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides 3'-5' DNA Helicase Activity Lateral Element Negative Regulation Of Cell Division Four-way Junction DNA Binding DNA Conformation Change K48-linked Deubiquitinase Activity Structural Constituent Of Nuclear Pore Nuclear Localization Sequence Binding DNA Double-strand Break Processing
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