WLS and HRH1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		WLS	HRH1
Description		Wnt ligand secretion mediator	histamine receptor H1
Image
GO Annotations	Cellular Component	Golgi Membrane Endosome Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Endomembrane System Membrane Cytoplasmic Vesicle Membrane Endocytic Vesicle Membrane Organelle Membrane Cytoplasmic Vesicle Early Endosome Membrane Extracellular Exosome	Cytosol Plasma Membrane Membrane Dendrite Synapse
	Molecular Function	Protein Binding Wnt-protein Binding Identical Protein Binding	G Protein-coupled Receptor Activity Histamine Receptor Activity
	Biological Process	Mesoderm Formation Intracellular Protein Transport Anterior/posterior Axis Specification Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Midbrain Development Hindbrain Development Exocrine Pancreas Development Positive Regulation Of Canonical NF-kappaB Signal Transduction Wnt Protein Secretion Positive Regulation Of Wnt Protein Secretion Cementum Mineralization Positive Regulation Of Canonical Wnt Signaling Pathway	Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Memory Visual Learning Regulation Of Vascular Permeability Positive Regulation Of Vasoconstriction Regulation Of Synaptic Plasticity Cellular Response To Histamine
Pathways		WNT ligand biogenesis and trafficking	Histamine receptors G alpha (q) signalling events
Drugs			Citalopram Benzatropine Ziprasidone Clemastine Amitriptyline Olanzapine Cetirizine Terfenadine Buclizine Clozapine Doxylamine Mirtazapine Dexbrompheniramine Loxapine Promazine Triprolidine Prochlorperazine Cyproheptadine Loratadine Imipramine Chlorpromazine Haloperidol Nortriptyline Amoxapine Lamotrigine Hydroxyzine Cinnarizine Astemizole Trazodone Paroxetine Azatadine Trimipramine Risperidone Meclizine Carbinoxamine Epinastine Benzquinamide Olopatadine Propiomazine Tripelennamine Tolazoline Brompheniramine Methdilazine Repaglinide Ketotifen Maprotiline Fexofenadine Desloratadine Azelastine Dimenhydrinate Promethazine Mequitazine Diphenhydramine Emedastine Levocabastine Chlorpheniramine Doxepin Diphenylpyraline Desipramine Orphenadrine Escitalopram Cyclizine Quetiapine Bromodiphenhydramine Aripiprazole Chlorprothixene Alimemazine Paliperidone Methotrimeprazine Aceprometazine Phenindamine Pheniramine Zuclopenthixol Clofedanol Flunarizine Bepotastine Tesmilifene Iloperidone HY10275 OBE101 SO-101 Histamine Epicept NP-1 Cariprazine Mianserin Pizotifen Asenapine Ocaperidone Levocetirizine Esmirtazapine Mepyramine Betahistine Alcaftadine Antazoline Chloropyramine Dimetindene Isothipendyl Perospirone Chlorcyclizine Butriptyline Dosulepin Viloxazine Lorpiprazole Acrivastine Dexchlorpheniramine maleate Thonzylamine Bilastine Rupatadine Aripiprazole lauroxil
Diseases
GWAS		Bone mineral density (spine) ( 26911590) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Femoral neck bone mineral density ( 32239398 29499414) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) HDL cholesterol levels in HIV infection ( 33109212) Heel bone mineral density ( 30598549 28869591) Lumbar spine bone mineral density ( 22504420 29499414) Perceived intensity of sucrose ( 31005972) Postoperative complication after cardiac surgery ( 30678657) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Male-pattern baldness ( 28196072) Mortality in sepsis ( 27639821) Pulse pressure ( 27841878) Systolic blood pressure ( 27618447 27618452 27841878)
Interacting Genes		6 interacting genes: CCR2 DRD2 GPR37 HRH1 OPRM1 SMO	12 interacting genes: ACE2 ADGRA3 ATP6V0A1 CD81 CNBP DHRS7 LIMS2 MAT2B SLC35B1 SLC43A2 WLS YIPF3
Entrez ID		79971	3269
HPRD ID		10980	02544
Ensembl ID		ENSG00000116729	ENSG00000196639
Uniprot IDs		Q5T9L3	P35367
PDB IDs		7DRT 7KC4 8TZO 8TZP 8TZR 8TZS	3RZE 7DFL 8YN2
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Activity Dendrite G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Behavioral Response To Ethanol Response To Histamine Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Secretion By Cell Negative Regulation Of Cytosolic Calcium Ion Concentration Perikaryon Response To Morphine Negative Regulation Of Secretion Neuropeptide Binding Positive Regulation Of Neurogenesis G-protein Alpha-subunit Binding Dopamine Metabolic Process Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Signal Transduction Positive Regulation Of Multicellular Organismal Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Development Positive Regulation Of Nervous System Development G Protein-coupled Peptide Receptor Activity Homeostasis Of Number Of Cells Within A Tissue Sensory Perception Of Pain Regulation Of Neuroblast Proliferation Catecholamine Metabolic Process Nervous System Process Neuroblast Proliferation Synapse Ciliary Membrane Positive Regulation Of Neural Precursor Cell Proliferation Visual Learning G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Neurogenesis Visual Behavior Regulation Of Multicellular Organism Growth Biogenic Amine Metabolic Process Signal Transduction Negative Regulation Of Protein Secretion Plasma Membrane Positive Regulation Of MAPK Cascade Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Protein Transport Positive Regulation Of Cell Development	Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Macrophage Fusion Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Virus Receptor Activity Myoblast Fusion Involved In Skeletal Muscle Regeneration G-quadruplex DNA Formation UDP-galactose Transmembrane Transport UDP-galactose Transmembrane Transporter Activity UDP-glucose Transmembrane Transporter Activity UDP-glucose Transmembrane Transport Methionine Adenosyltransferase Regulator Activity Methionine Adenosyltransferase Complex Cholangiocyte Proliferation Negative Regulation Of Hepatocyte Proliferation Regulation Of Cholangiocyte Proliferation Negative Regulation Of Cholangiocyte Proliferation Endocytic Vesicle Membrane Organic Cation Transport Positive Regulation Of L-proline Import Across Plasma Membrane Angiotensin-mediated Drinking Behavior Regulation Of Amine Transport Entry Receptor-mediated Virion Attachment To Host Cell Peptidyl-dipeptidase Activity Wnt Protein Secretion L-methionine Transmembrane Transporter Activity L-isoleucine Transmembrane Transporter Activity L-phenylalanine Transmembrane Transporter Activity Methionine Transport Negative Regulation Of L-leucine Import Across Plasma Membrane Organic Anion Transport Plasma Membrane Negative Regulation Of Transcription By RNA Polymerase III S-adenosylmethionine Biosynthetic Process Viral Translation Viral Life Cycle Positive Regulation Of Wnt Protein Secretion Phenylalanine Transport
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