WLS

Gene Name		wntless Wnt ligand secretion mediator
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Plasma Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane Early Endosome Membrane Dendrite Membrane Dendrite Cytoplasm
	Molecular Function	Signal Transducer Activity Protein Binding Wnt-protein Binding Mu-type Opioid Receptor Binding
	Biological Process	Mesoderm Formation Anterior/posterior Axis Specification Wnt Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 Signaling by Wnt Signaling by WNT in cancer WNT ligand biogenesis and trafficking
Drugs
Diseases
GWAS		Bone mineral density ( 22504420)
Protein-protein Interactions		1 interactors: OPRM1
Entrez ID		79971
HPRD ID		10980
Ensembl ID		ENSG00000116729
Uniprot IDs		Q5T9L3
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Wnt Protein Secretion Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway Cellular Response To Morphine Positive Regulation Of Appetite Cellular Response To Isoquinoline Alkaloid Negative Regulation Of CAMP-mediated Signaling Acute Inflammatory Response To Antigenic Stimulus Negative Regulation Of Cytosolic Calcium Ion Concentration Opioid Receptor Signaling Pathway Behavioral Response To Ethanol Positive Regulation Of CAMP-mediated Signaling Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Response To Food Cellular Response To Ammonium Ion Regulation Of Appetite Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Negative Regulation Of Adenylate Cyclase Activity Regulation Of CAMP-mediated Signaling Response To Food Negative Regulation Of Lyase Activity Regulation Of Sensory Perception Of Pain Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of CAMP Metabolic Process Inflammatory Response To Antigenic Stimulus Dopamine Receptor Signaling Pathway Cellular Response To Alkaloid Negative Regulation Of Nucleotide Metabolic Process Response To Morphine Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Response To Cocaine Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Neurological System Process Regulation Of Adenylate Cyclase Activity Regulation Of Nitric Oxide Biosynthetic Process Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Cyclase Activity Regulation Of Excitatory Postsynaptic Membrane Potential Acute Inflammatory Response Regulation Of Postsynaptic Membrane Potential Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of CAMP Biosynthetic Process Sensory Perception Of Pain Neuropeptide Signaling Pathway Response To Ammonium Ion
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