WLS

Name	Wnt ligand secretion mediator
Structure
Interactors	6 interactors: CCR2 DRD2 GPR37 HRH1 OPRM1 SMO
GO Annotations	Cellular Component	Golgi Membrane Endosome Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Endomembrane System Membrane Cytoplasmic Vesicle Membrane Endocytic Vesicle Membrane Organelle Membrane Cytoplasmic Vesicle Early Endosome Membrane Extracellular Exosome
	Molecular Function	Protein Binding Wnt-protein Binding Identical Protein Binding
	Biological Process	Mesoderm Formation Intracellular Protein Transport Anterior/posterior Axis Specification Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Midbrain Development Hindbrain Development Exocrine Pancreas Development Positive Regulation Of Canonical NF-kappaB Signal Transduction Wnt Protein Secretion Positive Regulation Of Wnt Protein Secretion Cementum Mineralization Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways	WNT ligand biogenesis and trafficking
GWAS	Bone mineral density (spine) ( 26911590 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Femoral neck bone mineral density ( 32239398 29499414 ) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398 ) HDL cholesterol levels in HIV infection ( 33109212 ) Heel bone mineral density ( 30598549 28869591 ) Lumbar spine bone mineral density ( 22504420 29499414 ) Perceived intensity of sucrose ( 31005972 ) Postoperative complication after cardiac surgery ( 30678657 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 )
Entrez ID	79971
HPRD ID	10980
Ensembl ID	ENSG00000116729
Uniprot IDs	Q5T9L3
PDB IDs	7DRT 7KC4 8TZO 8TZP 8TZR 8TZS
GO Terms Enriched among Interactors ?	G Protein-coupled Receptor Activity Dendrite G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Behavioral Response To Ethanol Response To Histamine Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Secretion By Cell Negative Regulation Of Cytosolic Calcium Ion Concentration Perikaryon Response To Morphine Negative Regulation Of Secretion Neuropeptide Binding Positive Regulation Of Neurogenesis G-protein Alpha-subunit Binding Dopamine Metabolic Process Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Signal Transduction Positive Regulation Of Multicellular Organismal Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Development Positive Regulation Of Nervous System Development G Protein-coupled Peptide Receptor Activity Homeostasis Of Number Of Cells Within A Tissue Sensory Perception Of Pain Regulation Of Neuroblast Proliferation Catecholamine Metabolic Process Nervous System Process Neuroblast Proliferation Synapse Ciliary Membrane Positive Regulation Of Neural Precursor Cell Proliferation Visual Learning G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Neurogenesis Visual Behavior Regulation Of Multicellular Organism Growth Biogenic Amine Metabolic Process Signal Transduction Negative Regulation Of Protein Secretion Plasma Membrane Positive Regulation Of MAPK Cascade Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Protein Transport Positive Regulation Of Cell Development