HRH1

Description		histamine receptor H1
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Dendrite Synapse
	Molecular Function	G Protein-coupled Receptor Activity Histamine Receptor Activity
	Biological Process	Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Memory Visual Learning Regulation Of Vascular Permeability Positive Regulation Of Vasoconstriction Regulation Of Synaptic Plasticity Cellular Response To Histamine
Pathways		Histamine receptors G alpha (q) signalling events
Drugs		Citalopram Benzatropine Ziprasidone Clemastine Amitriptyline Olanzapine Cetirizine Terfenadine Buclizine Clozapine Doxylamine Mirtazapine Dexbrompheniramine Loxapine Promazine Triprolidine Prochlorperazine Cyproheptadine Loratadine Imipramine Chlorpromazine Haloperidol Nortriptyline Amoxapine Lamotrigine Hydroxyzine Cinnarizine Astemizole Trazodone Paroxetine Azatadine Trimipramine Risperidone Meclizine Carbinoxamine Epinastine Benzquinamide Olopatadine Propiomazine Tripelennamine Tolazoline Brompheniramine Methdilazine Repaglinide Ketotifen Maprotiline Fexofenadine Desloratadine Azelastine Dimenhydrinate Promethazine Mequitazine Diphenhydramine Emedastine Levocabastine Chlorpheniramine Doxepin Diphenylpyraline Desipramine Orphenadrine Escitalopram Cyclizine Quetiapine Bromodiphenhydramine Aripiprazole Chlorprothixene Alimemazine Paliperidone Methotrimeprazine Aceprometazine Phenindamine Pheniramine Zuclopenthixol Clofedanol Flunarizine Bepotastine Tesmilifene Iloperidone HY10275 OBE101 SO-101 Histamine Epicept NP-1 Cariprazine Mianserin Pizotifen Asenapine Ocaperidone Levocetirizine Esmirtazapine Mepyramine Betahistine Alcaftadine Antazoline Chloropyramine Dimetindene Isothipendyl Perospirone Chlorcyclizine Butriptyline Dosulepin Viloxazine Lorpiprazole Acrivastine Dexchlorpheniramine maleate Thonzylamine Bilastine Rupatadine Aripiprazole lauroxil
Diseases
GWAS		Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Male-pattern baldness ( 28196072) Mortality in sepsis ( 27639821) Pulse pressure ( 27841878) Systolic blood pressure ( 27618447 27618452 27841878)
Novel Interacting Genes		2 novel interacting genes: BBS5 NAB2
Interacting Genes		12 interacting genes: ACE2 ADGRA3 ATP6V0A1 CD81 CNBP DHRS7 LIMS2 MAT2B SLC35B1 SLC43A2 WLS YIPF3
Entrez ID		3269
HPRD ID		02544
Ensembl ID		ENSG00000196639
Uniprot IDs		P35367
PDB IDs		3RZE 7DFL 8YN2
Enriched GO Terms of Interacting Partners?		Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Macrophage Fusion Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Virus Receptor Activity Myoblast Fusion Involved In Skeletal Muscle Regeneration G-quadruplex DNA Formation UDP-galactose Transmembrane Transport UDP-galactose Transmembrane Transporter Activity UDP-glucose Transmembrane Transporter Activity UDP-glucose Transmembrane Transport Methionine Adenosyltransferase Regulator Activity Methionine Adenosyltransferase Complex Cholangiocyte Proliferation Negative Regulation Of Hepatocyte Proliferation Regulation Of Cholangiocyte Proliferation Negative Regulation Of Cholangiocyte Proliferation Endocytic Vesicle Membrane Organic Cation Transport Positive Regulation Of L-proline Import Across Plasma Membrane Angiotensin-mediated Drinking Behavior Regulation Of Amine Transport Entry Receptor-mediated Virion Attachment To Host Cell Peptidyl-dipeptidase Activity Wnt Protein Secretion L-methionine Transmembrane Transporter Activity L-isoleucine Transmembrane Transporter Activity L-phenylalanine Transmembrane Transporter Activity Methionine Transport Negative Regulation Of L-leucine Import Across Plasma Membrane Organic Anion Transport Plasma Membrane Negative Regulation Of Transcription By RNA Polymerase III S-adenosylmethionine Biosynthetic Process Viral Translation Viral Life Cycle Positive Regulation Of Wnt Protein Secretion Phenylalanine Transport
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