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RABEP2 and FRAT1
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
RABEP2
FRAT1
Gene Name
rabaptin, RAB GTPase binding effector protein 2
frequently rearranged in advanced T-cell lymphomas 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Early Endosome
Intracellular Membrane-bounded Organelle
Cytosol
Molecular Function
GTPase Activator Activity
Growth Factor Activity
Biological Process
Endocytosis
Protein Transport
Positive Regulation Of GTPase Activity
Embryonic Axis Specification
Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways
misspliced GSK3beta mutants stabilize beta-catenin
APC truncation mutants have impaired AXIN binding
T41 mutants of beta-catenin aren't phosphorylated
TCF7L2 mutants don't bind CTBP
truncated APC mutants destabilize the destruction complex
Signaling by Wnt
APC truncation mutants are not K63 polyubiquitinated
disassembly of the destruction complex and recruitment of AXIN to the membrane
S37 mutants of beta-catenin aren't phosphorylated
Degradation of beta-catenin by the destruction complex
RNF mutants show enhanced WNT signaling and proliferation
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
XAV939 inhibits tankyrase, stabilizing AXIN
Beta-catenin phosphorylation cascade
truncations of AMER1 destabilize the destruction complex
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
AXIN missense mutants destabilize the destruction complex
S45 mutants of beta-catenin aren't phosphorylated
deletions in the AMER1 gene destabilize the destruction complex
TCF dependent signaling in response to WNT
AMER1 mutants destabilize the destruction complex
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Signaling by WNT in cancer
Drugs
Diseases
GWAS
Inflammatory bowel disease (
23128233
)
Obesity (
23563607
)
Protein-Protein Interactions
5 interactors:
FBXO25
FRAT1
RAB4A
RAB5A
UBC
13 interactors:
DVL1
GPRASP2
GRN
GSK3B
KCNK5
KRT18
LAMC3
LMAN2
LTBP4
PLSCR1
PSMA3
RABEP2
TDRD7
Entrez ID
79874
10023
HPRD ID
17948
03935
Ensembl ID
ENSG00000177548
ENSG00000165879
Uniprot IDs
B4DHR0
Q9H5N1
Q92837
PDB IDs
1GNG
3ZRK
3ZRL
3ZRM
4AFJ
Enriched GO Terms of Interacting Partners
?
Rab Protein Signal Transduction
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Wnt Signaling Pathway
Receptor Internalization Involved In Canonical Wnt Signaling Pathway
Regulation Of Endosome Size
Regulation Of Endocytosis
Endosomal Transport
Ras Protein Signal Transduction
Regulation Of Canonical Wnt Signaling Pathway
Wnt Signaling Pathway
Antigen Processing And Presentation
Protein Localization To Microtubule
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Negative Regulation Of Canonical Wnt Signaling Pathway
Protein Localization To Cytoskeleton
Positive Regulation Of Cellular Protein Catabolic Process
Positive Regulation Of Wnt Signaling Pathway
Negative Regulation Of Wnt Signaling Pathway
Positive Regulation Of Protein Catabolic Process
Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Proteolysis
Negative Regulation Of Protein Binding
Positive Regulation Of Proteolysis
Negative Regulation Of Transferase Activity
Regulation Of Wnt Signaling Pathway
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Golgi To Plasma Membrane CFTR Protein Transport
Positive Regulation Of Proteasomal Protein Catabolic Process
Transport
Regulation Of Protein Catabolic Process
Negative Regulation Of Type B Pancreatic Cell Development
Superior Temporal Gyrus Development
Apoptotic Process
Canonical Wnt Signaling Pathway
Negative Regulation Of Binding
Programmed Cell Death
Extrinsic Apoptotic Signaling Pathway
Cell Death
Death
Convergent Extension Involved In Neural Plate Elongation
Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity
Re-entry Into Mitotic Cell Cycle
Negative Regulation Of Neuron Maturation
Protein Localization
Establishment Of Localization In Cell
Hypermethylation Of CpG Island
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Binding
Collateral Sprouting
Cellular Response To Interleukin-3
Sensory Organ Development
Phosphatidylserine Biosynthetic Process
Convergent Extension Involved In Organogenesis
Negative Regulation Of Glycogen (starch) Synthase Activity
Regulation Of Neuron Maturation
Protein Transport
Regulation Of Catalytic Activity
Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of Dendrite Morphogenesis
Tagcloud
?
apc
axin1
cadherin
catenin
ck1
colon
destruction
du145
elucidate
emt
gsk3beta
ht29
inhibiting
involves
localization
maintaining
mesenchymal
modulate
ndrg1
pak4
precise
prevents
ser33
thr41
transforming
translocation
transporter
upregulation
wnt
Tagcloud (Difference)
?
apc
axin1
cadherin
catenin
ck1
colon
destruction
du145
elucidate
emt
gsk3beta
ht29
inhibiting
involves
localization
maintaining
mesenchymal
modulate
ndrg1
pak4
precise
prevents
ser33
thr41
transforming
translocation
transporter
upregulation
wnt
Tagcloud (Intersection)
?