RBFA and ERLIN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RBFA	ERLIN1
Description		ribosome binding factor A	ER lipid raft associated 1
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Protein-containing Complex Membrane Raft
	Molecular Function	Protein Binding	Protein Binding Lipid Binding Cholesterol Binding Ubiquitin Protein Ligase Binding
	Biological Process	RRNA Processing Biological_process	Lipid Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process SREBP Signaling Pathway ERAD Pathway Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Fatty Acid Biosynthetic Process
Pathways			ABC-family proteins mediated transport Defective CFTR causes cystic fibrosis AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs
Diseases
GWAS			Alanine aminotransferase levels ( 34315874 33547301 33339817) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 34315874 33547301) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) General cognitive ability ( 29844566) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Liver enzyme levels ( 18940312) Liver enzyme levels (alanine transaminase) ( 33972514) Refractive error ( 32231278) Response to radiotherapy in cancer (late toxicity) ( 24785509) Squamous cell lung carcinoma ( 28604730) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		22 interacting genes: ABHD5 AGTRAP ANK1 CACFD1 CAV3 CMTM5 CMTM6 DERL2 ERLIN1 FATE1 FKBP7 GPR152 GPX8 HIGD1C LEPROTL1 MDK PEX12 RHEX SMIM5 SYP SYPL1 YIF1A	8 interacting genes: AGR3 BNIP2 FA2H FILNC1 RBFA SEC22A SEC23A VMA12
Entrez ID		79863	10613
HPRD ID		07959	08502
Ensembl ID		ENSG00000101546	ENSG00000107566
Uniprot IDs		Q8N0V3	O75477
PDB IDs		2E7G 7PNX 7PNY 7PNZ 7PO0 7X9U 8CSR 8CSS 8CST 8CSU 8IPL 8IPM
Enriched GO Terms of Interacting Partners?		Membrane	Endoplasmic Reticulum Membrane Endoplasmic Reticulum Sebaceous Gland Cell Differentiation 4-hydroxysphinganine Ceramide Fatty Acyl 2-hydroxylase Activity Free Fatty Acid 2-hydroxylase Activity Glucosylceramide Biosynthetic Process Fatty Acid 2-hydroxylase Activity Regulation Of Sebum Secreting Cell Proliferation Regulation Of Acinar Cell Proliferation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Central Nervous System Myelin Maintenance Membrane Organization COPII-coated Vesicle Budding Galactosylceramide Biosynthetic Process Galactosylceramide Metabolic Process Glucosylceramide Metabolic Process Vacuolar Proton-transporting V-type ATPase Complex Assembly Proton-transporting V-type ATPase Complex Assembly Peripheral Nervous System Myelin Maintenance Spindle Pole Centrosome Response To Oxygen-glucose Deprivation GTPase Activator Activity COPII Vesicle Coat Golgi Vesicle Transport Myelin Maintenance Plasma Membrane Raft Organization Glycosylceramide Metabolic Process COPI-coated Vesicle Membrane Lysosomal Protein Catabolic Process Oxysterol Binding Vacuolar Proton-transporting V-type ATPase Complex Cellular Response To Increased Oxygen Levels Protein Catabolic Process In The Vacuole Dystroglycan Binding COPII-coated Vesicle Cargo Loading
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