MYH14 and GFI1B

Number of citations: 0 (PubMedID 16713569)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		MYH14	GFI1B
Name		myosin heavy chain 14	growth factor independent 1B transcriptional repressor
Structure			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Brush Border Membrane Myosin Complex Myosin II Complex Axon Growth Cone Myosin Filament Actomyosin Extracellular Exosome Myosin II Filament Supramolecular Fiber	Nucleus Nucleoplasm Transcription Regulator Complex Plasma Membrane Nuclear Matrix
	Molecular Function	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Calmodulin Binding ATP Binding Actin Filament Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Mitotic Cytokinesis Skeletal Muscle Contraction Mitochondrion Organization Skeletal Muscle Tissue Development Sensory Perception Of Sound Regulation Of Cell Shape Neuronal Action Potential Actin Filament-based Movement Actomyosin Structure Organization Vocalization Behavior	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Hemopoiesis Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs	None
Drugs		(S)-blebbistatin Mant-Adp Tetrafluoroaluminate Ion (3aS)-3a-hydroxy-5-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one (3aS)-3a-hydroxy-7-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one (3aS)-3a-hydroxy-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one trifluoro-[hydroxy-[hydroxy-[2-(N-methyl-2-nitro-anilino)ethoxy]phosphoryl]oxy-phosphoryl]oxy-beryllium(1-)	None
GWAS		Disc degeneration (lumbar) ( 22993228 ) Glucose homeostasis traits ( 25524916 )	Basophil percentage of white cells ( 27863252 ) Cardiometabolic and hematological traits ( 27668658 ) Eosinophil count ( 27863252 32888494 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 27863252 32888494 ) Granulocyte count ( 27863252 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 27863252 ) Immature fraction of reticulocytes ( 32888494 27863252 ) Lymphocyte percentage of white cells ( 32888494 ) Mean corpuscular hemoglobin ( 32888494 27863252 ) Mean corpuscular hemoglobin concentration ( 32888494 ) Mean corpuscular volume ( 27863252 32888494 ) Mean platelet volume ( 27863252 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Myeloid white cell count ( 27863252 ) Myeloproliferative neoplasms ( 33057200 ) Neutrophil count ( 32888494 ) Neutrophil percentage of granulocytes ( 27863252 ) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701 ) Platelet count ( 27863252 32888494 ) Platelet distribution width ( 27863252 32888494 ) Plateletcrit ( 27863252 32888494 ) Red blood cell count ( 32888494 ) Red cell distribution width ( 28957414 27863252 32888494 ) Reticulocyte count ( 27863252 32888494 ) Reticulocyte fraction of red cells ( 27863252 32888494 ) Sum eosinophil basophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) White blood cell count ( 27863252 32888494 ) White blood cell count (basophil) ( 27863252 )
Interacting Genes		6 interacting genes: FNDC3B GFI1B ITSN1 PDE4B RNF10 SNAPIN	72 interacting genes: ACTN1 AGRN AJUBA ANKS3 ATXN2 BABAM2 BECN1 BEGAIN BEND5 BRCA1 CCDC136 CCDC85B CENPB COPS5 CPAP DNAJA3 DTNA DZANK1 EFEMP1 EFEMP2 EGFL7 FBLN1 FBLN5 GPAT4 GRIP2 GRN HECW1 HGS HNRNPK HSPG2 IFFO1 JAG2 KALRN KIF17 LAMB1 LTBP4 LZTS2 MATR3 MEGF6 MEGF8 MID2 MON1A MYH14 NELL1 NELL2 NOTCH1 NSMF PDE4DIP PDLIM5 PDZD4 PHC2 PICK1 POLR1H PSMA3 RAB11FIP4 RCHY1 RCOR1 RINT1 RNF31 RUNDC3A TAF1 TLE5 TMF1 TNS2 TRAF1 TRIM27 TRIP6 TSPYL2 TXNDC11 USHBP1 VSNL1 ZNRF3
Entrez ID		79784	8328
HPRD ID		10543	05088
Ensembl ID		ENSG00000105357	ENSG00000165702
Uniprot IDs		A1L2Z2 B3KWH4 Q7Z406	A0A024R8F3 Q5VTD9
PDB IDs		5I4E 5JLH	Not available
GO Terms Enriched among Interactors		None	Calcium Ion Binding Regulation Of Cell Communication Regulation Of Signaling Elastic Fiber Regulation Of Signal Transduction Extracellular Matrix Structural Constituent Elastic Fiber Assembly Transcription Coactivator Activity Integrin Binding Embryo Implantation Basement Membrane Auditory Receptor Cell Fate Commitment Protein Kinase C Binding Extracellular Matrix Negative Regulation Of Cell Communication Negative Regulation Of Signaling Focal Adhesion Assembly Regulation Of Growth Protein Binding Developmental Process Extracellular Matrix Assembly Nuclear Ubiquitin Ligase Complex Negative Regulation Of Canonical Wnt Signaling Pathway Mitotic G2 DNA Damage Checkpoint Signaling Stress Fiber BRCA1-A Complex Cell-substrate Junction Assembly Protein Modification By Small Protein Conjugation Cell-substrate Junction Organization Negative Regulation Of Signal Transduction Post-translational Protein Modification Ubiquitin-protein Transferase Activity Ubiquitin Protein Ligase Activity Negative Regulation Of Wnt Signaling Pathway Cytoplasm Identical Protein Binding Regulation Of Cellular Component Organization Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Cell Population Proliferation Neuronal Ion Channel Clustering Astral Microtubule Organization Regulation Of Programmed Cell Death Protein Ubiquitination Vascular Associated Smooth Muscle Cell Development