NLRX1 and TMEM25

		NLRX1	TMEM25
Description		NLR family member X1	transmembrane protein 25
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Cytosol Plasma Membrane Membrane	Extracellular Region Lysosome Endosome Late Endosome Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding	Protein Binding
	Biological Process	Immune System Process Negative Regulation Of Macrophage Cytokine Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of RIG-I Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Negative Regulation Of Innate Immune Response Negative Regulation Of Inflammatory Response	Regulation Of Protein Stability Negative Regulation Of Excitatory Postsynaptic Potential
Pathways		DDX58/IFIH1-mediated induction of interferon-alpha/beta Negative regulators of DDX58/IFIH1 signaling Regulation of NF-kappa B signaling
Drugs
Diseases
GWAS		Mean reticulocyte volume ( 32888494)
Interacting Genes		1 interacting genes: SARM1	3 interacting genes: ATXN1L GLRX3 RABGGTB
Entrez ID		79671	84866
HPRD ID		17640	11635
Ensembl ID		ENSG00000160703	ENSG00000149582
Uniprot IDs		A0A9L9PX86 Q86UT6	B7Z1M8 E9PKP3 Q86YD3
PDB IDs		3UN9
Enriched GO Terms of Interacting Partners?		NADP+ Nucleosidase Activity Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Extrinsic Component Of Synaptic Membrane NAD+ Nucleosidase Activity Negative Regulation Of Growth Rate Guanylate Cyclase Inhibitor Activity RES Complex Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway NAD+ Catabolic Process ABC-type Sterol Transporter Activity	Protein Geranylgeranylation Rab-protein Geranylgeranyltransferase Complex Protein Prenyltransferase Activity Rab Geranylgeranyltransferase Activity Protein Geranylgeranyltransferase Activity Prenyltransferase Activity Protein Prenylation [2Fe-2S] Cluster Assembly Negative Regulation Of RIG-I Signaling Pathway POZ Domain Binding Positive Regulation Of Hematopoietic Stem Cell Proliferation Iron-sulfur Cluster Assembly Complex Negative Regulation Of Macrophage Cytokine Production
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