NLRX1 and ABCG4

		NLRX1	ABCG4
Description		NLR family member X1	ATP binding cassette subfamily G member 4
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Cytosol Plasma Membrane Membrane	Endosome Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity ABC-type Sterol Transporter Activity Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Dimerization Activity ABC-type Transporter Activity
	Biological Process	Immune System Process Negative Regulation Of Macrophage Cytokine Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of RIG-I Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Negative Regulation Of Innate Immune Response Negative Regulation Of Inflammatory Response	Regulation Of DNA-templated Transcription Lipid Transport Positive Regulation Of Cholesterol Efflux Sterol Transport Cholesterol Efflux Cholesterol Homeostasis Positive Regulation Of Cholesterol Biosynthetic Process Transmembrane Transport Cellular Response To High Density Lipoprotein Particle Stimulus Cellular Response To Leukemia Inhibitory Factor
Pathways		DDX58/IFIH1-mediated induction of interferon-alpha/beta Negative regulators of DDX58/IFIH1 signaling Regulation of NF-kappa B signaling	ABC transporters in lipid homeostasis
Drugs
Diseases
GWAS		Mean reticulocyte volume ( 32888494)	Lymphocyte count ( 27863252) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 27863252 32888494)
Interacting Genes		1 interacting genes: SARM1	6 interacting genes: ABCG1 GPR152 PLEKHF2 SGTB TMEM50A ZDHHC17
Entrez ID		79671	64137
HPRD ID		17640	12130
Ensembl ID		ENSG00000160703	ENSG00000172350
Uniprot IDs		A0A9L9PX86 Q86UT6	Q9H172
PDB IDs		3UN9
Enriched GO Terms of Interacting Partners?		NADP+ Nucleosidase Activity Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Extrinsic Component Of Synaptic Membrane NAD+ Nucleosidase Activity Negative Regulation Of Growth Rate Guanylate Cyclase Inhibitor Activity RES Complex Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway NAD+ Catabolic Process ABC-type Sterol Transporter Activity
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