C3orf52 and ESAM

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		C3orf52	ESAM
Description		chromosome 3 open reading frame 52	endothelial cell adhesion molecule
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Membrane	Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Membrane Protein-containing Complex Anchoring Junction
	Molecular Function	Protein Binding	Protein Binding Cell-cell Adhesion Mediator Activity
	Biological Process		Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Intracellular Protein Localization Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Maintenance Of Blood-brain Barrier Bicellular Tight Junction Assembly Cell-cell Adhesion
Pathways			Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494)	Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576) Schizophrenia ( 25056061 29483656)
Interacting Genes		74 interacting genes: ADGRG3 AGER AHNAK2 AMIGO1 AQP6 ATP1B4 BIK CCL21 CCL26 CD33 CHST13 CLDN7 CLEC10A CNMD CPLX4 CREB3 DEXI ERGIC3 ERP29 ESAM FAM209A FFAR2 FKBP7 FNDC9 FOLH1 FUT3 GJA8 GJB1 GOLM2 GORAB GPX8 HHLA2 HSD17B13 KEL KIR2DL3 KLRC1 LEUTX LHFPL5 LMNA LRRC25 MFF MGST2 MGST3 MRGPRX3 MUC1 NCR3LG1 NEMP1 NPDC1 NSG2 PVR QPCTL REEP3 RNF150 SAR1A SGTA SLC10A1 SLC10A2 SLC10A6 SLC16A2 SLC23A2 SLC39A2 SPRING1 ST6GALNAC3 STOM SYNE4 TIMMDC1 TMEM179B TMEM237 TMEM45B TMEM52B TMEM80 TMPRSS2 UPK2 ZNRF3	3 interacting genes: C3orf52 MTDH TMBIM6
Entrez ID		79669	90952
HPRD ID		08018	13280
Ensembl ID		ENSG00000114529	ENSG00000149564
Uniprot IDs		Q5BVD1	Q96AP7
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Bile Acid:sodium Symporter Activity Plasma Membrane Glutathione Peroxidase Activity Bile Acid And Bile Salt Transport Leukotriene-C4 Synthase Activity	Negative Regulation Of Calcium Ion Transport Into Cytosol Endoplasmic Reticulum Endoribonuclease Inhibitor Activity Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of IRE1-mediated Unfolded Protein Response Intercellular Canaliculus IRE1-mediated Unfolded Protein Response Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Immunoglobulin Production Cellular Response To Unfolded Protein Regulation Of Cellular Response To Hypoxia Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of IRE1-mediated Unfolded Protein Response Response To L-glutamate Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Topologically Incorrect Protein Negative Regulation Of RNA Splicing
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