ESAM

Description		endothelial cell adhesion molecule
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Membrane Protein-containing Complex Anchoring Junction
	Molecular Function	Protein Binding Cell-cell Adhesion Mediator Activity
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Intracellular Protein Localization Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Maintenance Of Blood-brain Barrier Bicellular Tight Junction Assembly Cell-cell Adhesion
Pathways		Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576) Schizophrenia ( 25056061 29483656)
Interacting Genes		3 interacting genes: C3orf52 MTDH TMBIM6
Entrez ID		90952
HPRD ID		13280
Ensembl ID		ENSG00000149564
Uniprot IDs		Q96AP7
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Calcium Ion Transport Into Cytosol Endoplasmic Reticulum Endoribonuclease Inhibitor Activity Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of IRE1-mediated Unfolded Protein Response Intercellular Canaliculus IRE1-mediated Unfolded Protein Response Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Immunoglobulin Production Cellular Response To Unfolded Protein Regulation Of Cellular Response To Hypoxia Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of IRE1-mediated Unfolded Protein Response Response To L-glutamate Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Topologically Incorrect Protein Negative Regulation Of RNA Splicing
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