FYCO1 and MON1A

		FYCO1	MON1A
Description		FYVE and coiled-coil domain autophagy adaptor 1	MON1 vesicular trafficking associated A
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Endosome Late Endosome Autophagosome Golgi Apparatus Membrane Cytoplasmic Vesicle	Cytosol Mon1-Ccz1 Complex
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Plus-end-directed Vesicle Transport Along Microtubule Positive Regulation Of Autophagosome Maturation	Protein Targeting To Vacuole Protein Secretion Vesicle-mediated Transport
Pathways			RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Bone mineral content ( 31790847) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Severe COVID-19 infection with respiratory failure (analysis II) ( 32558485)	Age at first birth ( 27798627) Body mass index ( 28892062 29273807 25673413) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Extremely high intelligence ( 29520040) Gastroesophageal reflux disease ( 31527586) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		4 interacting genes: APP KDM1A PRMT6 RAF1	6 interacting genes: GFI1B MAPK6 RABGEF1 RGS2 TAB1 VPS33A
Entrez ID		79443	84315
HPRD ID		06215	17586
Ensembl ID		ENSG00000163820	ENSG00000164077
Uniprot IDs		Q9BQS8	Q86VX9
PDB IDs		5CX3 5D94 7BQI
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex Regulation Of Cellular Component Organization PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Enzyme Binding Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Neuron Maturation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To CAMP Lipoprotein Particle Chromatin Binding Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Import Microglia Development Glial Cell Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To CAMP Protein Localization To Extracellular Region Establishment Of Protein Localization To Extracellular Region Protein Secretion Death-inducing Signaling Complex Assembly Telomeric Repeat-containing RNA Binding Regulation Of Signal Transduction By P53 Class Mediator FAD-dependent H3K4me/H3K4me3 Demethylase Activity Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Histone Arginine N-methyltransferase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Purine-containing Compound Chromatin Remodeling Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Cell Differentiation Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cell Maturation Regulation Of Protein Metabolic Process Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon	Septin Cytoskeleton Negative Regulation Of Glycine Import Across Plasma Membrane Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Intracellular Transport Organelle Localization Lysosome Localization Negative Regulation Of Kit Signaling Pathway Negative Regulation Of Mast Cell Cytokine Production Autophagosome Vesicle Localization Kit Signaling Pathway Adenylate Cyclase Inhibitor Activity Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Relaxation Of Smooth Muscle Relaxation Of Vascular Associated Smooth Muscle Mitogen-activated Protein Kinase P38 Binding Cellular Localization Establishment Of Localization In Cell Endosome Transport Along Microtubule Mast Cell Migration Negative Regulation Of Mast Cell Degranulation Cytoskeleton-dependent Intracellular Transport CORVET Complex Late Endosome Plus-end-directed Vesicle Transport Along Microtubule Plus-end-directed Organelle Transport Along Microtubule Positive Regulation Of Autophagosome Maturation Positive Regulation Of CGAS/STING Signaling Pathway Microtubule-based Transport Presynaptic Endosome Clathrin Complex Intracellular Signaling Cassette Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of Mast Cell Activation
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