DHRS11 and GSDMB

		DHRS11	GSDMB
Description		dehydrogenase/reductase 11	gasdermin B
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GO Annotations	Cellular Component	Extracellular Region	Cytoplasm Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) Activity Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor 17-beta-hydroxysteroid Dehydrogenase (NADP+) Activity	Phosphatidylserine Binding Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Wide Pore Channel Activity Phosphatidylinositol-4-phosphate Binding Cardiolipin Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Estrogen Biosynthetic Process Steroid Metabolic Process	Programmed Cell Death Killing Of Cells Of Another Organism Defense Response To Bacterium Defense Response To Gram-negative Bacterium Killing By Host Of Symbiont Cells Transmembrane Transport Pyroptotic Inflammatory Response Granzyme-mediated Programmed Cell Death Signaling Pathway Cytotoxic T Cell Pyroptotic Cell Death
Pathways
Drugs		Nicotinamide adenine dinucleotide phosphate
Diseases
GWAS		Body mass index ( 26426971) Estimated glomerular filtration rate ( 31015462)	Adult asthma ( 30787307) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergy ( 27182965) Asthma ( 34103634 32296059 31959851 31619474 31361310 30929738 29273806 28461288 20860503 21804549) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 29273806 34022066 24241537 31036433 27611488 30929738) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atrial fibrillation ( 30061737) Bronchial hyperresponsiveness in asthma ( 27439200) Cervical cancer ( 23817570) Childhood asthma with severe exacerbations ( 33328473) Crohn's disease ( 28067908) Dermatomyositis or juvenile dermatomyositis ( 26362759) Feeling miserable ( 29500382) Fractional exhaled nitric oxide (childhood) ( 24315451) IgM levels ( 28628107) Inflammatory bowel disease ( 23128233 28067908) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Monocyte percentage of white cells ( 27863252) Primary biliary cholangitis ( 23000144 20639880 30643196) Primary biliary cirrhosis ( 22961000) Refractive error ( 32231278) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Self-reported allergy ( 23817569) Serum alkaline phosphatase levels ( 33339817) Subcutaneous adipose tissue ( 27918534) Systemic lupus erythematosus ( 26502338) Systemic sclerosis ( 31672989 28314753) Type 1 diabetes ( 30659077 25751624) Ulcerative colitis ( 28067908) White blood cell count ( 21738480 32888494)
Interacting Genes		1 interacting genes: DLG3	8 interacting genes: AGT APP CLK1 HIVEP1 IGFBP2 ORM1 PEBP1 SERPINA1
Entrez ID		79154	55876
HPRD ID		08331	17082
Ensembl ID		ENSG00000278535	ENSG00000073605
Uniprot IDs		Q6UWP2	Q8TAX9
PDB IDs		1XG5	5TIB 5TJ2 5TJ4 7WJQ 8EFP 8ET1 8ET2 8GTJ 8GTK 8GTN
Enriched GO Terms of Interacting Partners?		Cytotoxic T Cell Pyroptotic Cell Death Phosphatase Binding Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Of Planar Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Ionotropic Glutamate Receptor Binding Receptor Clustering Receptor Localization To Synapse AMPA Glutamate Receptor Complex Biological Process Involved In Interaction With Symbiont Phosphatidylinositol-4-phosphate Binding Pyroptotic Inflammatory Response Pyroptotic Cell Death Wide Pore Channel Activity Killing By Host Of Symbiont Cells Granzyme-mediated Programmed Cell Death Signaling Pathway Cardiolipin Binding Protein Localization To Synapse Phosphatidylserine Binding Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Phosphatidylinositol-4,5-bisphosphate Binding Neuromuscular Junction Protein Localization To Cell Junction Defense Response To Gram-negative Bacterium Postsynaptic Density Membrane Kinase Binding Bicellular Tight Junction Killing Of Cells Of Another Organism Phospholipid Binding	Serine-type Endopeptidase Inhibitor Activity Platelet Alpha Granule Lumen Regulation Of Superoxide Anion Generation Positive Regulation Of Superoxide Anion Generation Peptidase Inhibitor Activity
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