CCDC86 and AHNAK

Data Source: HiPPIP (Novel)

		CCDC86	AHNAK
Name		coiled-coil domain containing 86	AHNAK nucleoprotein
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus	Nucleus Cytoplasm Lysosomal Membrane Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane T-tubule Vesicle Sarcolemma Costamere Cell-cell Contact Zone Membrane Raft Extracellular Exosome Plasma Membrane Protein Complex
	Molecular Function	RNA Binding Protein Binding	RNA Binding Protein Binding Identical Protein Binding S100 Protein Binding Cadherin Binding Structural Molecule Activity Conferring Elasticity
	Biological Process	Chromosome Segregation Mitotic Nuclear Division	Regulation Of RNA Splicing Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Plasma Membrane Repair
GWAS		Wegener's granulomatosis ( 23740775 )	A body shape index ( 34021172 ) Alanine aminotransferase levels ( 33547301 ) Alzheimer's disease (late onset) ( 28714976 ) Blond vs. brown/black hair color ( 30531825 ) Chronic obstructive pulmonary disease-related biomarkers ( 23144326 ) Cutaneous melanoma or hair colour ( 32341527 ) Gamma glutamyl transferase levels ( 33339817 29403010 ) HDL cholesterol levels ( 32203549 ) Heel bone mineral density ( 28869591 30598549 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Lung function (FEV1) ( 28166213 ) Monocyte percentage of white cells ( 32888494 ) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311 ) Serum alkaline phosphatase levels ( 31666285 ) Triglyceride levels ( 32203549 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Interacting Genes		3 interacting genes: DLST OGT SRPK2	13 interacting genes: AKT1 CDKN2A EGFR FNDC3B KLHL40 MEOX2 NOL9 POT1 S100B SUMO2 USP7 WEE2-AS1 XRCC4
Entrez ID		79080	79026
HPRD ID		08322	14684
Ensembl ID		ENSG00000110104	ENSG00000124942
Uniprot IDs		Q9H6F5	B4DTV0 Q09666 Q9BVU3
PDB IDs		8FL0 8FL2 8FL3 8FL4 8INK 8IPD 8IPX 8IPY 8IR1 8IR3	4DRW 4FTG 4HRG
GO Terms Enriched among Interactors		Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway Co-transcriptional RNA 3'-end Processing, Cleavage And Polyadenylation Pathway MRNA Cleavage And Polyadenylation Specificity Factor Complex MRNA 3'-end Processing Dihydrolipoyllysine-residue Succinyltransferase Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly	Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Regulation Of Proteolysis Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Response To UV-A Negative Regulation Of Post-translational Protein Modification Negative Regulation Of Protein Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Signal Transduction By P53 Class Mediator SUMO Transferase Activity Negative Regulation Of Protein Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Modification Process Regulation Of Peptidyl-serine Phosphorylation Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Proteolysis Regulation Of DNA Metabolic Process Regulation Of Cellular Localization Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Protein Ubiquitination Positive Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Myelination Regulation Of Cellular Response To Stress Regulation Of TRNA Methylation Response To Epidermal Growth Factor Ligase Inhibitor Activity Protein Sumoylation Multivesicular Body, Internal Vesicle Lumen FHA Domain Binding Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Positive Regulation Of Catabolic Process Regulation Of Post-translational Protein Modification Nucleoplasm Positive Regulation Of Cell Cycle G1/S Phase Transition