CCDC86 and TUT1

Data Source: HiPPIP (Novel)

		CCDC86	TUT1
Name		coiled-coil domain containing 86	terminal uridylyl transferase 1, U6 snRNA-specific
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus	Nucleus Nucleoplasm Nucleolus Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Nuclear Speck
	Molecular Function	RNA Binding Protein Binding	Nucleotide Binding Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding ATP Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity U6 SnRNA Binding Enzyme Binding Metal Ion Binding RNA Uridylyltransferase Activity Enzyme-substrate Adaptor Activity Poly(A) RNA Polymerase Activity
	Biological Process	Chromosome Segregation Mitotic Nuclear Division	MRNA Processing SnRNA Processing RNA 3'-end Processing MRNA 3'-end Processing U6 SnRNA 3'-end Processing Regulation Of RNA Metabolic Process Histone MRNA Catabolic Process Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway
GWAS		Wegener's granulomatosis ( 23740775 )	A body shape index ( 34021172 ) Cerebrospinal fluid immune biomarker levels ( 32066700 ) Post bronchodilator FEV1 ( 26634245 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Interacting Genes		3 interacting genes: DLST OGT SRPK2	4 interacting genes: HMOX1 IL32 KATNBL1 PIN1
Entrez ID		79080	64852
HPRD ID		08322	15226
Ensembl ID		ENSG00000110104	ENSG00000149016
Uniprot IDs		Q9H6F5	A0A0A8K9B1 F5H0R1 Q9H6E5
PDB IDs		8FL0 8FL2 8FL3 8FL4 8INK 8IPD 8IPX 8IPY 8IR1 8IR3	2E5G 5WU1 5WU2 5WU3 5WU4 5WU5 5WU6 8IDF 9J8P
GO Terms Enriched among Interactors		Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway Co-transcriptional RNA 3'-end Processing, Cleavage And Polyadenylation Pathway MRNA Cleavage And Polyadenylation Specificity Factor Complex MRNA 3'-end Processing Dihydrolipoyllysine-residue Succinyltransferase Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly	Heme Oxidation Smooth Muscle Hyperplasia Heme Oxygenase (decyclizing) Activity Wound Healing Involved In Inflammatory Response Cis-trans Isomerase Activity Positive Regulation Of Type III Interferon Production Protein Peptidyl-prolyl Isomerization Phosphothreonine Residue Binding Cellular Response To Cisplatin Response To Cisplatin Midbody Phosphoserine Residue Binding Negative Regulation Of Viral Life Cycle Regulation Of Type III Interferon Production Mitotic Nuclear Division Katanin Complex Smooth Muscle Adaptation Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Porphyrin-containing Compound Catabolic Process Erythrocyte Homeostasis Heme Catabolic Process Mitogen-activated Protein Kinase Kinase Binding GTPase Activating Protein Binding Ubiquitin Ligase Activator Activity Negative Regulation Of Ferroptosis Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Low-density Lipoprotein Particle Clearance Regulation Of Ferroptosis