TUT1 and CCDC86

Data Source: HiPPIP (Novel)

		TUT1	CCDC86
Name		terminal uridylyl transferase 1, U6 snRNA-specific	coiled-coil domain containing 86
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Nuclear Speck	Nucleus Nucleoplasm Chromosome Nucleolus
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding ATP Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity U6 SnRNA Binding Enzyme Binding Metal Ion Binding RNA Uridylyltransferase Activity Enzyme-substrate Adaptor Activity Poly(A) RNA Polymerase Activity	RNA Binding Protein Binding
	Biological Process	MRNA Processing SnRNA Processing RNA 3'-end Processing MRNA 3'-end Processing U6 SnRNA 3'-end Processing Regulation Of RNA Metabolic Process Histone MRNA Catabolic Process Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway	Chromosome Segregation Mitotic Nuclear Division
GWAS		A body shape index ( 34021172 ) Cerebrospinal fluid immune biomarker levels ( 32066700 ) Post bronchodilator FEV1 ( 26634245 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	Wegener's granulomatosis ( 23740775 )
Novel Interactors		1 novel interactors: CCDC86	7 novel interactors: AHNAK C9orf153 CPSF7 MS4A14 MS4A15 MS4A8 TUT1
Interacting Genes		4 interacting genes: HMOX1 IL32 KATNBL1 PIN1	3 interacting genes: DLST OGT SRPK2
Entrez ID		64852	79080
HPRD ID		15226	08322
Ensembl ID		ENSG00000149016	ENSG00000110104
Uniprot IDs		A0A0A8K9B1 F5H0R1 Q9H6E5	Q9H6F5
PDB IDs		2E5G 5WU1 5WU2 5WU3 5WU4 5WU5 5WU6 8IDF 9J8P	8FL0 8FL2 8FL3 8FL4 8INK 8IPD 8IPX 8IPY 8IR1 8IR3
GO Terms Enriched among Interactors		Heme Oxidation Smooth Muscle Hyperplasia Heme Oxygenase (decyclizing) Activity Wound Healing Involved In Inflammatory Response Cis-trans Isomerase Activity Positive Regulation Of Type III Interferon Production Protein Peptidyl-prolyl Isomerization Phosphothreonine Residue Binding Cellular Response To Cisplatin Response To Cisplatin Midbody Phosphoserine Residue Binding Negative Regulation Of Viral Life Cycle Regulation Of Type III Interferon Production Mitotic Nuclear Division Katanin Complex Smooth Muscle Adaptation Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Porphyrin-containing Compound Catabolic Process Erythrocyte Homeostasis Heme Catabolic Process Mitogen-activated Protein Kinase Kinase Binding GTPase Activating Protein Binding Ubiquitin Ligase Activator Activity Negative Regulation Of Ferroptosis Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Low-density Lipoprotein Particle Clearance Regulation Of Ferroptosis	Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway Co-transcriptional RNA 3'-end Processing, Cleavage And Polyadenylation Pathway MRNA Cleavage And Polyadenylation Specificity Factor Complex MRNA 3'-end Processing Dihydrolipoyllysine-residue Succinyltransferase Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly