NOC4L and NT5C2

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NOC4L	NT5C2
Gene Name		nucleolar complex associated 4 homolog (S. cerevisiae)	5-nucleotidase, cytosolic II
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Integral Component Of Membrane Noc4p-Nop14p Complex Nuclear Membrane Small-subunit Processome	Cytosol
	Molecular Function	Protein Binding Poly(A) RNA Binding	Nucleotide Binding Protein Binding 5'-nucleotidase Activity Metal Ion Binding Nucleoside Phosphotransferase Activity
	Biological Process	Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing	Purine Nucleobase Metabolic Process Purine Nucleotide Catabolic Process Phosphorylation Dephosphorylation Drug Metabolic Process Small Molecule Metabolic Process IMP Metabolic Process Adenosine Metabolic Process Nucleobase-containing Small Molecule Metabolic Process
Pathways			Purine catabolism Purine metabolism Metabolism of nucleotides Abacavir transport and metabolism Abacavir metabolism
Drugs			Adenosine triphosphate Ribavirin
Diseases
GWAS			Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood pressure ( 21572416 21909110) Coronary heart disease ( 21378990) Schizophrenia ( 21926974 22688191 23894747) Systolic blood pressure ( 19430483 21909115)
Protein-Protein Interactions		13 interactors: BHLHE40 DAZAP2 DNAJA3 IKZF1 KRT15 NECAB2 NT5C2 PLSCR1 PRSS23 SSSCA1 TSC22D4 USHBP1 VIM	10 interactors: ATP5O CALM1 FXR2 MOB1B MOB3B MOB3C NME7 NOC4L NUDT18 SDCBP
Entrez ID		79050	22978
HPRD ID		14543	02686
Ensembl ID		ENSG00000184967	ENSG00000076685
Uniprot IDs		Q9BVI4	A8K6K2 B7Z382 P49902
PDB IDs			2J2C 2JC9 2JCM 2XCV 2XCW 2XCX 2XJB 2XJC 2XJD 2XJE 2XJF 4H4B
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Neutrophil Differentiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Cell Activation Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process T Cell Differentiation Cell Activation Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Phosphatidylserine Biosynthetic Process Positive Regulation Of NK T Cell Differentiation Activation-induced Cell Death Of T Cells Bergmann Glial Cell Differentiation Positive Regulation Of T Cell Activation Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Granulocyte Differentiation Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Skeletal Muscle Acetylcholine-gated Channel Clustering Lymphocyte Differentiation Positive Regulation Of Cell-cell Adhesion Regulation Of Innate Immune Response Phospholipid Scrambling Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Positive Regulation Of Immune System Process Mitochondrial DNA Replication T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Heterocycle Metabolic Process Regulation Of T Cell Activation Adenosine Metabolic Process Apoptotic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cell Activation Lymph Node Development Regulation Of Gene Expression Programmed Cell Death T Cell Apoptotic Process Peyer's Patch Development Leukocyte Cell-cell Adhesion Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Intermediate Filament Organization Homotypic Cell-cell Adhesion Negative Regulation Of Cellular Metabolic Process	Purine Nucleoside Metabolic Process Ribonucleotide Metabolic Process Nucleoside Metabolic Process Purine Nucleotide Metabolic Process Ribose Phosphate Metabolic Process Nucleoside Diphosphate Metabolic Process Organophosphate Metabolic Process Nucleoside Triphosphate Biosynthetic Process GDP Catabolic Process DGDP Catabolic Process DADP Catabolic Process Nucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Phosphate-containing Compound Metabolic Process Positive Regulation Of Extracellular Vesicular Exosome Assembly Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Purine Nucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Regulation Of High Voltage-gated Calcium Channel Activity Ciliary Receptor Clustering Involved In Smoothened Signaling Pathway Regulation Of Extracellular Vesicular Exosome Assembly Purine Ribonucleoside Diphosphate Catabolic Process Nucleobase-containing Small Molecule Catabolic Process Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Membrane Organization Positive Regulation Of Phosphorylation Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Ribonucleoside Diphosphate Catabolic Process Establishment Of Localization In Cell Nucleoside Diphosphate Catabolic Process Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Deoxyribonucleoside Diphosphate Metabolic Process Detection Of Calcium Ion Substrate-dependent Cell Migration, Cell Extension Energy Derivation By Oxidation Of Organic Compounds Nucleotide Biosynthetic Process Purine Ribonucleoside Catabolic Process Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Phosphoprotein Phosphatase Activity Small Molecule Metabolic Process Cellular Localization Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Mitochondrial ATP Synthesis Coupled Proton Transport Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity
Tagcloud ?			atp2b1 atxn2 bdkrb2 cacnb2 csk cyp171a cyp17a1 cyp1a2 eh gwas hfe jan meant mthfr nppa nppb overlapped pharmacogenomics plcd3 plekha7 sh2b3 stk39 tbx3 tbx5 ulk3 ulk4 umod wnk4 znf652
Tagcloud (Difference) ?			atp2b1 atxn2 bdkrb2 cacnb2 csk cyp171a cyp17a1 cyp1a2 eh gwas hfe jan meant mthfr nppa nppb overlapped pharmacogenomics plcd3 plekha7 sh2b3 stk39 tbx3 tbx5 ulk3 ulk4 umod wnk4 znf652
Tagcloud (Intersection) ?