KCTD15 and WIPI1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		KCTD15	WIPI1
Gene Name		potassium channel tetramerization domain containing 15	WD repeat domain, phosphoinositide interacting 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Golgi Membrane Pre-autophagosomal Structure Autophagic Vacuole Membrane Cytoplasm Trans-Golgi Network Cytosol Cytoskeleton Endosome Membrane Extrinsic Component Of Membrane Clathrin-coated Vesicle Pre-autophagosomal Structure Membrane
	Molecular Function		Receptor Binding Estrogen Receptor Binding Phosphatidylinositol-3-phosphate Binding Androgen Receptor Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Multicellular Organismal Development Protein Homooligomerization	Autophagic Vacuole Assembly Mitochondrion Degradation Protein Lipidation Autophagy Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cellular Response To Nitrogen Starvation Endoplasmic Reticulum Unfolded Protein Response Protein Localization To Pre-autophagosomal Structure Cellular Protein Metabolic Process Nucleophagy Vesicle Targeting, Trans-Golgi To Endosome
Pathways			IRE1alpha activates chaperones XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS		Body mass index ( 19079260 19079261 20935630) Major depressive disorder ( 23377640) Obesity-related traits ( 23251661) Weight ( 19079260)
Protein-Protein Interactions		7 interactors: ATXN1 ENSA KCTD1 NOTCH2NL REN TRIM27 WIPI1	5 interactors: AR ESR1 ESR2 KCTD15 PPA1
Entrez ID		79047	55062
HPRD ID		13765	08540
Ensembl ID		ENSG00000153885	ENSG00000070540
Uniprot IDs		Q96SI1	G5EA37 Q5MNZ9
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Oligomerization Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Negative Regulation Of Interleukin-2 Secretion Vesicle Targeting, Trans-Golgi To Endosome Renin-angiotensin Regulation Of Aldosterone Production Cellular Component Assembly Endosomal Transport Negative Regulation Of Calcium Ion Import Drinking Behavior Response To CGMP Protein Homooligomerization Interferon-gamma Secretion Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Protein Localization To Pre-autophagosomal Structure Protein Complex Assembly Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Angiotensin Maturation Negative Regulation Of RNA Biosynthetic Process Regulation Of Angiotensin Metabolic Process Regulation Of Blood Volume By Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Negative Regulation Of Viral Release From Host Cell Cellular Response To Nitrogen Starvation Golgi To Endosome Transport Regulation Of Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Protein Secretion Negative Regulation Of Phosphorylation Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Nucleophagy Negative Regulation Of Viral Transcription Response To Nutrient Levels Beta-amyloid Metabolic Process Regulation Of Viral Release From Host Cell Regulation Of Calcium Ion Import Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Response To Immobilization Stress Response To Extracellular Stimulus Intracellular Transport Regulation Of Cellular Process Response To Stimulus Negative Regulation Of Neuroblast Proliferation Mitochondrion Degradation Vesicle Targeting, To, From Or Within Golgi	Intracellular Steroid Hormone Receptor Signaling Pathway Prostate Gland Development Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Vagina Development Uterus Development Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Intracellular Estrogen Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Female Genitalia Development DNA-templated Transcription, Initiation Sex Differentiation Prostate Gland Epithelium Morphogenesis Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Prostate Gland Morphogenesis Urogenital System Development Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Genitalia Development Response To Steroid Hormone Ovarian Follicle Development Gland Development Reproductive Structure Development Reproductive System Development Cellular Response To Hormone Stimulus Ovulation Cycle Process Female Gonad Development Negative Regulation Of Integrin Biosynthetic Process Ovulation Cycle Development Of Primary Female Sexual Characteristics Developmental Process Involved In Reproduction Diphosphate Metabolic Process Response To Lipid Gland Morphogenesis Transcription From RNA Polymerase II Promoter Response To Organic Cyclic Compound Response To Hormone Positive Regulation Of Integrin Biosynthetic Process Prostate Epithelial Cord Elongation Epithelial Cell Development Regulation Of Integrin Biosynthetic Process Negative Regulation Of Signal Transduction Gonad Development Development Of Primary Sexual Characteristics Epithelial Cell Maturation Involved In Prostate Gland Development Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Hormone-mediated Apoptotic Signaling Pathway
Tagcloud ?		adiposity alleles bcdin3d bdnf bmi chinese circumference dgkg etv5 europeans faim2 former fto gnpda2 hong kong lin7c loci lost mc4r modestly mtch2 negr1 obesity sec16b sh2b1 t2d tmem18 waist	28c atg16l autophagic autophagosome autophagy carbonyl coa desaturase dimethylamino earliest immunoblot lc3 microscopic n2 n5 oleic p62 puncta pyridinedicarboxamide rapamycin scd scd1 sqstm1 starvation stearoyl structurally thiazolyl ulk1 unsaturated
Tagcloud (Difference) ?		adiposity alleles bcdin3d bdnf bmi chinese circumference dgkg etv5 europeans faim2 former fto gnpda2 hong kong lin7c loci lost mc4r modestly mtch2 negr1 obesity sec16b sh2b1 t2d tmem18 waist	28c atg16l autophagic autophagosome autophagy carbonyl coa desaturase dimethylamino earliest immunoblot lc3 microscopic n2 n5 oleic p62 puncta pyridinedicarboxamide rapamycin scd scd1 sqstm1 starvation stearoyl structurally thiazolyl ulk1 unsaturated
Tagcloud (Intersection) ?