REEP6 and SNX8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		REEP6	SNX8
Description		receptor accessory protein 6	sorting nexin 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Photoreceptor Inner Segment Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle	Endosome Cytosol Membrane Retromer Complex Cytoplasmic Vesicle Early Endosome Membrane
	Molecular Function	Protein Binding	Protein Binding Lipid Binding Phosphatidylinositol Binding Identical Protein Binding
	Biological Process	Endoplasmic Reticulum Organization Regulation Of Intracellular Transport Detection Of Light Stimulus Involved In Visual Perception	Intracellular Protein Transport Protein Transport Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi
Pathways
Drugs
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Dimensional psychopathology (Social) ( 29496196) LDL cholesterol ( 30275531) Mean platelet volume ( 32888494) Neuropathic pain in head and neck cancer ( 29884837) Red blood cell count ( 32888494) Schizophrenia ( 22688191 23974872) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		46 interacting genes: AQP6 ARL6IP1 ATP5PF BIK CD79A CDC37 CERT1 COQ8A CYB561 CYB5R3 EBAG9 FHIP1B GJA8 GORASP2 GPR152 HMBOX1 HSD17B13 KRTAP3-1 LEPROTL1 LITAF LMNA LNX1 MIEF2 NDRG4 NTAQ1 PICK1 PTPN9 RPS20 SDCBP SLC30A8 SNX1 SNX11 SNX15 SNX8 SPG21 STING1 SYT16 TIMMDC1 TLCD4 TMED8 TMEM143 TMPPE TNS2 TXN2 WIPI2 ZFYVE21	6 interacting genes: ARL6IP1 C14orf119 FASN RABAC1 REEP6 WEE2-AS1
Entrez ID		92840	29886
HPRD ID		16629	11592
Ensembl ID		ENSG00000115255	ENSG00000106266
Uniprot IDs		A0A1L5BXV2 Q96HR9	Q9Y5X2
PDB IDs
Enriched GO Terms of Interacting Partners?		Lipid Binding Establishment Of Protein Localization Identical Protein Binding Membrane	Fatty Acid Synthase Activity [acyl-carrier-protein] S-acetyltransferase Activity [acyl-carrier-protein] S-malonyltransferase Activity (3R)-hydroxyacyl-[acyl-carrier-protein] Dehydratase Activity Fatty Acyl-[ACP] Hydrolase Activity Phosphopantetheine Binding Endoplasmic Reticulum Organization 3-oxoacyl-[acyl-carrier-protein] Synthase Activity Enoyl-[acyl-carrier-protein] Reductase (NADPH) Activity 3-oxoacyl-[acyl-carrier-protein] Reductase (NADPH) Activity Positive Regulation Of L-glutamate Import Across Plasma Membrane Pre-mRNA 5'-splice Site Binding Glycogen Granule Sec61 Translocon Complex Regulation Of Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Formation Neutrophil Differentiation Endoplasmic Reticulum Tubular Network Membrane Organization MRNA 5'-splice Site Recognition Regulation Of L-glutamate Import Across Plasma Membrane Response To Caloric Restriction Ether Lipid Biosynthetic Process Establishment Of Endothelial Intestinal Barrier Endoplasmic Reticulum Membrane Organization Cotranslational Protein Targeting To Membrane Ether Lipid Metabolic Process Monocyte Differentiation Proline-rich Region Binding Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Detection Of Light Stimulus Involved In Visual Perception U1 SnRNP Positive Regulation Of Amino Acid Transport Cellular Response To Interleukin-4 Fatty-acyl-CoA Biosynthetic Process Response To Interleukin-4 Granulocyte Differentiation Acetyl-CoA Metabolic Process
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