NABP2 and FBXL5

Number of citations of the paper that reports this interaction (PubMedID 25249620)
29

Data Source:
BioGRID (pull down)

		NABP2	FBXL5
Description		nucleic acid binding protein 2	F-box and leucine rich repeat protein 5
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Site Of Double-strand Break SOSS Complex	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding Single-stranded DNA Binding Protein Binding C-rich Strand Telomeric DNA Binding DNA Polymerase Binding G-rich Strand Telomeric DNA Binding	Ubiquitin-protein Transferase Activity Iron Ion Binding Protein Binding Metal Ion Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Damage Response Response To Ionizing Radiation Mitotic G2/M Transition Checkpoint Establishment Of Protein Localization To Telomere Positive Regulation Of Telomere Capping	Intracellular Iron Ion Homeostasis Protein Ubiquitination Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Monoatomic Cation Homeostasis Multicellular Organismal-level Iron Ion Homeostasis Inorganic Ion Homeostasis
Pathways		RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes	Association of TriC/CCT with target proteins during biosynthesis Neddylation Iron uptake and transport Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Estimated glomerular filtration rate in non-diabetics ( 31451708) Red blood cell count ( 32888494)
Interacting Genes		5 interacting genes: FBXL5 NBN PIGP RAD50 TP53	10 interacting genes: CITED2 CSNK2B DCTN1 EP300 LINC00839 NABP2 ORC4 PLK1 SKP1 SNCA
Entrez ID		79035	26234
HPRD ID		14522	05739
Ensembl ID		ENSG00000139579	ENSG00000118564
Uniprot IDs		Q9BQ15	Q9UKA1
PDB IDs		4OWT 4OWW 4OWX 5D8E 5D8F 8RBZ	3U9J 3U9M 3V5X 3V5Y 3V5Z 6VCD
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Chromosomal Region Telomeric 3' Overhang Formation Mre11 Complex BRCA1-C Complex Negative Regulation Of Chromosome Organization Negative Regulation Of Telomere Capping Site Of Double-strand Break Regulation Of Telomere Maintenance R-loop Processing Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of DNA Metabolic Process Regulation Of Telomere Capping DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Strand Elongation DNA Double-strand Break Processing Negative Regulation Of Mitotic Cell Cycle Double-strand Break Repair Negative Regulation Of Cell Cycle Phase Transition Replication Fork Regulation Of Chromosome Organization Negative Regulation Of Cell Cycle Process Homologous Recombination DNA Damage Response, Signal Transduction By P53 Class Mediator Neuroblast Proliferation Chromosome Organization Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Mitotic G2/M Transition Checkpoint Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Mitotic DNA Damage Checkpoint Signaling Protein Serine/threonine Kinase Activator Activity Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Telomere Maintenance Regulation Of DNA Metabolic Process Regulation Of Mitotic Cell Cycle DNA Repair Positive Regulation Of Organelle Organization Regulation Of Cellular Response To Stress Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Neural Precursor Cell Proliferation Positive Regulation Of Double-strand Break Repair DNA Damage Checkpoint Signaling Telomere Maintenance Signal Transduction By P53 Class Mediator Positive Regulation Of Chromosome Organization	Tau Protein Binding Protein Domain Specific Binding Protein Destabilization Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Membrane Disassembly Nuclear Membrane Disassembly PcG Protein Complex Regulation Of Microtubule Cytoskeleton Organization Molecular Function Activator Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cytosol Regulation Of Microtubule-based Process Establishment Of Spindle Localization Establishment Of Spindle Orientation Regulation Of Mitotic Spindle Organization Nuclear Membrane Organization Establishment Of Mitotic Spindle Localization Microtubule Binding Establishment Of Organelle Localization Spindle Localization Regulation Of Organelle Organization Establishment Of Mitotic Spindle Orientation Protein Localization To Chromatin Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Mitotic G2/M Transition Checkpoint Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission C-rich Strand Telomeric DNA Binding Response To Estrogen Regulation Of Microtubule Polymerization Protein-containing Complex Myeloid Cell Development Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Nucleus Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Histone H2B Acetyltransferase Activity
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