YIPF2 and RNF185

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		YIPF2	RNF185
Description		Yip1 domain family member 2	ring finger protein 185
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Trans Cisterna Endosome Golgi Apparatus Golgi Medial Cisterna Trans-Golgi Network Endomembrane System Membrane Transport Vesicle Late Endosome Membrane	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Protein Binding Small GTPase Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Binding Ubiquitin-like Protein Conjugating Enzyme Binding Protein-containing Complex Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Vesicle-mediated Transport	Immune System Process Ubiquitin-dependent Protein Catabolic Process Autophagy Protein Ubiquitination ERAD Pathway Protein K27-linked Ubiquitination Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Virus Protein Autoubiquitination Transmembrane Transport Positive Regulation Of Type I Interferon-mediated Signaling Pathway CGAS/STING Signaling Pathway Positive Regulation Of ERAD Pathway Endoplasmic Reticulum Mannose Trimming
Pathways			ABC-family proteins mediated transport Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs
Diseases
GWAS			Apolipoprotein A1 levels ( 32203549) Fish- and plant-related diet ( 32066663) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Waist circumference ( 28552196) White blood cell count ( 32888494)
Interacting Genes		24 interacting genes: AQP6 CREB3 ERGIC3 FATE1 FFAR2 GPR42 HSD17B13 LEPROTL1 PGRMC2 RNF185 RNF5 SHISAL2A SLC10A6 SLC30A2 SLC39A3 SLC71A2 SPCS1 STING1 SYPL2 TMEM143 TMEM14B TMX2 TVP23B YIPF6	30 interacting genes: APP CGAS CMTM5 CYB561A3 DVL2 FAM241B MALL MS4A13 MTNR1B MYADML2 NIPAL4 TMEM147 TMEM19 TMEM86A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2V1 UBE2W USP21 YIPF2 YIPF4 YIPF6
Entrez ID		78992	91445
HPRD ID		11332	08790
Ensembl ID		ENSG00000130733	ENSG00000138942
Uniprot IDs		K7ENM8 Q9BWQ6	Q96GF1
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Ubiquitin-like Protein Conjugating Enzyme Binding Endoplasmic Reticulum Membrane Transmembrane Transport Endoplasmic Reticulum Mannose Trimming Protein Alpha-1,2-demannosylation Positive Regulation Of Type I Interferon-mediated Signaling Pathway Identical Protein Binding Protein Deglycosylation Zinc Ion Transmembrane Transporter Activity Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Endoplasmic Reticulum Quality Control Compartment Zinc Ion Transmembrane Transport Zinc Ion Transport CGAS/STING Signaling Pathway Nitrate Transmembrane Transporter Activity Monoatomic Ion Transport Zinc Ion Import Into Zymogen Granule Zinc Ion Import Into Mitochondrion Zinc Ion Import Into Secretory Vesicle Positive Regulation Of Deacetylase Activity COPII-coated ER To Golgi Transport Vesicle Cyclic-di-GMP Binding STING Complex Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport Pattern Recognition Receptor Signaling Pathway Golgi Membrane Regulation Of Type I Interferon-mediated Signaling Pathway Innate Immune Response-activating Signaling Pathway Mitochondrial Membrane PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Retrograde Transporter Complex, Golgi To ER 2',3'-cyclic GMP-AMP Binding Activation Of Innate Immune Response Mitochondrial Outer Membrane Protein Binding Monoatomic Cation Transport Positive Regulation Of Cytokine-mediated Signaling Pathway	Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein K11-linked Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Monoubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification Process Proteolysis Involved In Protein Catabolic Process ATP Binding Protein K63-linked Ubiquitination Nucleotide Binding Transferase Activity ISG15 Transferase Activity Proteolysis ISG15-protein Conjugation Macromolecule Catabolic Process Golgi Trans Cisterna Golgi Medial Cisterna Protein Metabolic Process Positive Regulation Of Protein Polyubiquitination Protein Binding Protein K6-linked Ubiquitination Regulation Of Protein Polyubiquitination Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Frizzled Binding SUMO Conjugating Enzyme Activity 2',3'-cyclic GMP-AMP Synthase Activity
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