RNF185 and CGAS

Number of citations of the paper that reports this interaction (PubMedID 28273161)
68

Data Source:
BioGRID (affinity chromatography technology, enzymatic study, enzymatic study)

		RNF185	CGAS
Description		ring finger protein 185	cyclic GMP-AMP synthase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Quality Control Compartment	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Body Site Of Double-strand Break
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Binding Ubiquitin-like Protein Conjugating Enzyme Binding Protein-containing Complex Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Protein Binding ATP Binding GTP Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Transferase Activity Nucleotidyltransferase Activity Nucleosome Binding Protein Homodimerization Activity Metal Ion Binding 2',3'-cyclic GMP-AMP Synthase Activity Molecular Condensate Scaffold Activity Poly-ADP-D-ribose Modification-dependent Protein Binding
	Biological Process	Immune System Process Ubiquitin-dependent Protein Catabolic Process Autophagy Protein Ubiquitination ERAD Pathway Protein K27-linked Ubiquitination Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Virus Protein Autoubiquitination Transmembrane Transport Positive Regulation Of Type I Interferon-mediated Signaling Pathway CGAS/STING Signaling Pathway Positive Regulation Of ERAD Pathway Endoplasmic Reticulum Mannose Trimming	Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Defense Response To Virus By Host Immune System Process Regulation Of Immunoglobulin Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway DNA Repair DNA Damage Response Determination Of Adult Lifespan CAMP-mediated Signaling CGMP-mediated Signaling Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Paracrine Signaling Innate Immune Response Negative Regulation Of DNA Repair Regulation Of Immune Response Regulation Of T Cell Activation Defense Response To Virus Cellular Response To Exogenous DsRNA CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Cellular Senescence
Pathways		ABC-family proteins mediated transport Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	STING mediated induction of host immune responses
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Fish- and plant-related diet ( 32066663) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Waist circumference ( 28552196) White blood cell count ( 32888494)
Interacting Genes		30 interacting genes: APP CGAS CMTM5 CYB561A3 DVL2 FAM241B MALL MS4A13 MTNR1B MYADML2 NIPAL4 TMEM147 TMEM19 TMEM86A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2V1 UBE2W USP21 YIPF2 YIPF4 YIPF6	4 interacting genes: IRGM MARCHF8 OTUD3 RNF185
Entrez ID		91445	115004
HPRD ID		08790	12857
Ensembl ID		ENSG00000138942	ENSG00000164430
Uniprot IDs		Q96GF1	A0A7P0TBQ3 Q8N884
PDB IDs			4KM5 4LEV 4LEW 4MKP 4O67 4O68 4O69 5V8O 5VDO 5VDP 5VDQ 5VDR 5VDS 5VDT 5VDU 5VDV 5VDW 6CT9 6CTA 6EDB 6EDC 6LRC 6LRE 6LRI 6LRJ 6LRK 6LRL 6MJU 6MJW 6MJX 6NAO 6NFG 6NFO 6O47 6Y5D 6Y5E 7C0M 7CCQ 7CCR 7FTF 7FTG 7FTH 7FTI 7FTJ 7FTK 7FTL 7FTM 7FTN 7FTO 7FTP 7FTQ 7FTR 7FTS 7FTT 7FTU 7FTV 7FTW 7FTX 7FTY 7FTZ 7FU0 7FU1 7FU2 7FU3 7FU4 7FU5 7FU6 7FU7 7FU8 7FU9 7FUA 7FUB 7FUC 7FUD 7FUE 7FUF 7FUG 7FUH 7FUI 7FUJ 7FUK 7FUL 7FUM 7FUN 7FUO 7FUP 7FUQ 7FUR 8IME 8IMF 8IMG 8OKX 8OL1 8SHZ 8SI0 8SJ8 8WR8 9C3G 9ELX 9MDC 9MDD
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein K11-linked Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Monoubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification Process Proteolysis Involved In Protein Catabolic Process ATP Binding Protein K63-linked Ubiquitination Nucleotide Binding Transferase Activity ISG15 Transferase Activity Proteolysis ISG15-protein Conjugation Macromolecule Catabolic Process Golgi Trans Cisterna Golgi Medial Cisterna Protein Metabolic Process Positive Regulation Of Protein Polyubiquitination Protein Binding Protein K6-linked Ubiquitination Regulation Of Protein Polyubiquitination Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Frizzled Binding SUMO Conjugating Enzyme Activity 2',3'-cyclic GMP-AMP Synthase Activity	Post-translational Protein Modification Protein Modification Process Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Lipidation Involved In Autophagosome Assembly Protein K6-linked Deubiquitination Protein K27-linked Deubiquitination Protein Metabolic Process Innate Immune Response-activating Signaling Pathway Endoplasmic Reticulum Membrane Pattern Recognition Receptor Signaling Pathway Activation Of Innate Immune Response Regulation Of Cytokine-mediated Signaling Pathway Late Endosome Membrane Positive Regulation Of Lysosome Organization C-terminal Protein Lipidation Protein Stabilization Protein Polyubiquitination Immune Response Autophagy Ubiquitin-like Protein Conjugating Enzyme Binding Positive Regulation Of Innate Immune Response Intracellular Receptor Signaling Pathway Ubiquitin-protein Transferase Activity MHC Protein Binding Positive Regulation Of Xenophagy Positive Regulation Of Response To Type II Interferon Positive Regulation Of Type II Interferon-mediated Signaling Pathway Positive Regulation Of Autophagosome Maturation BH3 Domain Binding CAMKK-AMPK Signaling Cascade Positive Regulation Of Peptidyl-threonine Phosphorylation Ubiquitin Protein Ligase Activity Immune Response-activating Signaling Pathway Protein K11-linked Deubiquitination Regulation Of Protein Stability Protein Alpha-1,2-demannosylation Regulation Of Innate Immune Response Response To Virus Immune Response-regulating Signaling Pathway Endoplasmic Reticulum Mannose Trimming Protein K27-linked Ubiquitination Activation Of Immune Response Lysosomal Membrane Regulation Of Protein Complex Stability Negative Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Lysosome Organization Protein Targeting To Vacuole Involved In Autophagy Regulation Of Type II Interferon-mediated Signaling Pathway
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