ZKSCAN4 and ZNF397

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		ZKSCAN4	ZNF397
Description		zinc finger with KRAB and SCAN domains 4	zinc finger protein 397
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleolus Cytoplasm Cytosol Plasma Membrane Microtubule Cytoskeleton
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription
Pathways		Generic Transcription Pathway
Drugs
Diseases
GWAS		Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Basal metabolic rate ( 31453325) Basal metabolic rate variance ( 31453325) Brain morphology (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) Hip circumference adjusted for BMI ( 34021172) Refractive error ( 32231278) Schizophrenia ( 30285260) Subcortical volume (MOSTest) ( 32665545)	Facial morphology ( 29921221)
Interacting Genes		19 interacting genes: CABP5 IL36RN LXN MAP1LC3A MDM4 MEOX2 OGT OSGIN1 PSMA6 TIAM1 TRIM39 ZKSCAN7 ZNF397 ZNF483 ZNF496 ZSCAN20 ZSCAN22 ZSCAN30 ZSCAN32	8 interacting genes: LMO4 OGT PRKAA2 ZKSCAN4 ZNF396 ZNF410 ZSCAN12 ZSCAN22
Entrez ID		387032	84307
HPRD ID		15768	18335
Ensembl ID		ENSG00000187626	ENSG00000186812
Uniprot IDs		A0A0S2Z658 B7Z7H3 Q969J2	Q8NF99
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Zinc Ion Binding Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Protein Catabolic Process Metal Ion Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Purine Ribonucleoside Triphosphate Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Primary Metabolic Process Mitophagy Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Metal Ion Binding Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Regulation Of Metabolic Process Regulation Of Glycolytic Process Protein Localization To Lysosome Cellular Response To Glucose Stimulus Regulation Of Carbohydrate Catabolic Process Positive Regulation Of TORC1 Signaling Nucleus TORC1 Signaling Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of ATP Metabolic Process Cellular Response To Carbohydrate Stimulus TOR Signaling Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of TOR Signaling Intracellular Glucose Homeostasis Zinc Ion Binding Protein Localization To Vacuole [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Regulation Of TORC1 Signaling Histone H2BS36 Kinase Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Translational Initiation DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Cytoplasmic Translation Protein O-acetylglucosaminyltransferase Activity Ventral Spinal Cord Interneuron Differentiation Response To Glucose Transcription Coregulator Activity Negative Regulation Of Biosynthetic Process Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Protein-containing Complex Assembly Response To Monosaccharide Regulation Of Phosphorus Metabolic Process Protein Localization To Lipid Droplet Sequence-specific Double-stranded DNA Binding
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