WNT5A and IMPG1

		WNT5A	IMPG1
Description		Wnt family member 5A	interphotoreceptor matrix proteoglycan 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Extracellular Matrix Extracellular Exosome Schaffer Collateral - CA1 Synapse Postsynapse Glutamatergic Synapse	Photoreceptor Outer Segment Photoreceptor Inner Segment Extracellular Region Extracellular Matrix Interphotoreceptor Matrix Cell Projection Cell Periphery
	Molecular Function	Signaling Receptor Binding Frizzled Binding Receptor Tyrosine Kinase-like Orphan Receptor Binding Cytokine Activity Protein Binding Phospholipid Binding Protein Domain Specific Binding Receptor Ligand Activity Chemoattractant Activity Involved In Axon Guidance	Extracellular Matrix Structural Constituent Hyaluronic Acid Binding Heparin Binding Chondroitin Sulfate Binding
	Biological Process	Establishment Of Planar Polarity Somitogenesis Positive Regulation Of Cytokine Production Kidney Development Epithelial To Mesenchymal Transition Neural Tube Closure Positive Regulation Of Endothelial Cell Proliferation Heart Looping Morphogenesis Of An Epithelium Positive Regulation Of Mesenchymal Cell Proliferation Lens Development In Camera-type Eye Positive Regulation Of Cytokine Production Involved In Immune Response Primary Heart Field Specification Secondary Heart Field Specification Ventricular Septum Development Atrial Septum Development Type B Pancreatic Cell Development Pericardium Morphogenesis Axis Elongation Optic Cup Formation Involved In Camera-type Eye Development Inflammatory Response Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway JNK Cascade Determination Of Left/right Symmetry Axonogenesis Axon Guidance Hindgut Morphogenesis Midgut Development Intracellular Protein Localization Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Male Gonad Development Anterior/posterior Axis Specification, Embryo Anterior/posterior Pattern Specification Mesenchymal Cell Proliferation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Epithelial Cell Migration Macrophage Derived Foam Cell Differentiation Positive Regulation Of T Cell Chemotaxis Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Cell Migration Olfactory Bulb Interneuron Development Neural Tube Development Neurogenesis Cell Differentiation Neuron Differentiation Keratinocyte Differentiation Lung Development Embryonic Limb Morphogenesis BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Midbrain Development Positive Regulation Of Chemokine Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Protein Localization Positive Regulation Of Rac Protein Signal Transduction Limb Morphogenesis Non-canonical Wnt Signaling Pathway Post-anal Tail Morphogenesis Chemoattraction Of Serotonergic Neuron Axon Chemorepulsion Of Dopaminergic Neuron Axon Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Wound Healing Inner Ear Morphogenesis Embryonic Digit Morphogenesis Positive Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Cell Fate Commitment Establishment Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Angiogenesis Positive Regulation Of Ossification Positive Regulation Of Endocytosis Positive Regulation Of Meiotic Nuclear Division Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Development Of Primary Male Sexual Characteristics Negative Regulation Of Melanin Biosynthetic Process Positive Regulation Of Fibroblast Proliferation Paraxial Mesoderm Formation Digestive Tract Morphogenesis Notochord Morphogenesis Embryonic Skeletal System Development Genitalia Development Neuron Projection Morphogenesis Negative Regulation Of Axon Extension Involved In Axon Guidance Axon Extension Involved In Axon Guidance Hypophysis Morphogenesis Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Regulation Of Synapse Organization Negative Chemotaxis Cartilage Development Positive Regulation Of Timing Of Anagen Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Synapse Assembly Convergent Extension Convergent Extension Involved In Axis Elongation Convergent Extension Involved In Organogenesis Uterus Development Cervix Development Vagina Development Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Urinary Bladder Development Face Development Positive Regulation Of Type I Interferon-mediated Signaling Pathway Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Tube Closure Mesenchymal-epithelial Cell Signaling Negative Regulation Of Prostatic Bud Formation Mammary Gland Branching Involved In Thelarche Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Response To Cytokine Stimulus Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Mesodermal To Mesenchymal Transition Involved In Gastrulation Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of Cartilage Development Somite Development Secondary Palate Development Thymocyte Apoptotic Process Positive Regulation Of Thymocyte Apoptotic Process Cellular Response To Molecule Of Bacterial Origin Cellular Response To Lipopolysaccharide Cellular Response To Calcium Ion Cellular Response To Retinoic Acid Cellular Response To Type II Interferon Hematopoietic Stem Cell Proliferation Dopaminergic Neuron Differentiation Cellular Response To Transforming Growth Factor Beta Stimulus Stem Cell Proliferation Negative Regulation Of Mesenchymal Cell Proliferation Primitive Streak Formation Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Melanocyte Proliferation Presynapse Assembly Postsynapse Assembly Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynapse Organization Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Meiotic Nuclear Division Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Protein Kinase C Activity Positive Regulation Of Hematopoietic Stem Cell Proliferation Positive Regulation Of Protein Localization To Synapse Excitatory Synapse Assembly Inhibitory Synapse Assembly Negative Regulation Of Cell Proliferation In Midbrain Midbrain Dopaminergic Neuron Differentiation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Non-canonical Wnt Signaling Pathway Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Apoptotic Signaling Pathway	Visual Perception Extracellular Matrix Organization
Pathways		TCF dependent signaling in response to WNT TCF dependent signaling in response to WNT WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors) Negative regulation of TCF-dependent signaling by WNT ligand antagonists Ca2+ pathway Ca2+ pathway PCP/CE pathway PCP/CE pathway Asymmetric localization of PCP proteins WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping
Drugs
Diseases
GWAS		Carboplatin disposition in epthelial ovarian cancer ( 29367611) Height ( 28552196) Lung function (FEV1/FVC) ( 28166213) Metabolite levels ( 23823483) Type 2 diabetes ( 30130595)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Hip circumference adjusted for BMI ( 34021172) Longevity ( 30294719) Menarche (age at onset) ( 25231870) QT interval ( 29213071) Response to fenofibrate (total cholesterol levels) ( 27002377) Sleep activity levels ( 33075057) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		3 interacting genes: FZD1 FZD5 ROR2
Entrez ID		7474	3617
HPRD ID		01293	04186
Ensembl ID		ENSG00000114251	ENSG00000112706
Uniprot IDs		A0A384N611 B3KQX9 P41221	A0A087WYL3 Q17R60
PDB IDs
Enriched GO Terms of Interacting Partners?		Wnt-protein Binding Wnt Receptor Activity Endothelial Cell Differentiation Wnt Signaling Pathway Non-canonical Wnt Signaling Pathway Vasculature Development Positive Regulation Of Osteoblast Differentiation Clathrin-coated Endocytic Vesicle Membrane Methanethiol Oxidase Activity G Protein-coupled Receptor Activity	Chemorepulsion Of Axon Postsynapse Assembly Primary Heart Field Specification Positive Regulation Of Protein Kinase C Activity Foam Cell Differentiation Positive Regulation Of Thymocyte Apoptotic Process Positive Regulation Of Protein Localization To Synapse Regulation Of Timing Of Anagen Hypophysis Morphogenesis Macrophage Derived Foam Cell Differentiation Convergent Extension Involved In Axis Elongation Receptor Tyrosine Kinase-like Orphan Receptor Binding Melanocyte Proliferation Chemoattraction Of Serotonergic Neuron Axon Negative Regulation Of Melanin Biosynthetic Process Mesodermal To Mesenchymal Transition Involved In Gastrulation Urinary Bladder Development Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Mammary Gland Branching Involved In Thelarche Positive Regulation Of Timing Of Anagen Chemoattractant Activity Involved In Axon Guidance Wnt Signaling Pathway, Calcium Modulating Pathway Negative Regulation Of Cell Proliferation In Midbrain Regulation Of Prostatic Bud Formation Paraxial Mesoderm Formation Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Optic Cup Formation Involved In Camera-type Eye Development Notochord Morphogenesis Olfactory Bulb Interneuron Development Hindgut Morphogenesis Cervix Development Convergent Extension Involved In Organogenesis Chemorepulsion Of Dopaminergic Neuron Axon Development Of Primary Male Sexual Characteristics Negative Regulation Of Prostatic Bud Formation Chemoattraction Of Axon Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Pericardium Morphogenesis Development Of Primary Sexual Characteristics Negative Regulation Of Axon Extension Involved In Axon Guidance Mesenchymal-epithelial Cell Signaling Positive Regulation Of Neuron Projection Arborization Midgut Development Atrial Septum Development Lateral Sprouting From An Epithelium Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Negative Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Hematopoietic Stem Cell Proliferation Excitatory Synapse Assembly Thymocyte Apoptotic Process
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