DAGLA and VMA21

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DAGLA	VMA21
Description		diacylglycerol lipase alpha	vacuolar ATPase assembly factor VMA21
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Plasma Membrane Membrane Early Endosome Membrane Dendrite Membrane Dendritic Spine Membrane Cell Projection Varicosity Synapse Postsynaptic Membrane Postsynaptic Density Membrane	Lysosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane ER To Golgi Transport Vesicle Membrane Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Lipoprotein Lipase Activity Protein Binding Hydrolase Activity Metal Ion Binding Monoacylglycerol Lipase Activity	Protein Binding
	Biological Process	Lipid Metabolic Process Acylglycerol Metabolic Process Monoacylglycerol Biosynthetic Process Neuroblast Proliferation Lipid Catabolic Process Arachidonate Metabolic Process Neurogenesis Diacylglycerol Catabolic Process Retrograde Trans-synaptic Signaling By Endocannabinoid Regulation Of Neuroinflammatory Response Cannabinoid Biosynthetic Process	Lysosomal Lumen Acidification Vacuolar Proton-transporting V-type ATPase Complex Assembly
Pathways		Arachidonate production from DAG
Drugs
Diseases
GWAS		Bipolar disorder ( 28115744 31043756) Fasting plasma glucose ( 32902719) Immune reponse to smallpox (secreted IL-2) ( 22610502) Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Red blood cell fatty acid levels ( 25500335) Refractive error ( 32231278)
Interacting Genes		10 interacting genes: CMTM7 LHFPL5 MAL MALL MS4A13 STOM TMEM218 TRARG1 UPK1B VMA21	29 interacting genes: ABHD16A ADAM33 AQP6 ARL6IP1 ATP13A1 ATP6V0B BNIP1 CDIPT CLEC12B DAGLA HMOX2 INSIG2 LHFPL5 LYPD6B NINJ2 NIPAL3 ORMDL1 PLLP RTP2 SCD SLC25A46 SLC35E4 TECR THSD7A TMEM107 TMEM60 VAMP2 YIF1A YIPF1
Entrez ID		747	203547
HPRD ID		07092	18578
Ensembl ID		ENSG00000134780	ENSG00000160131
Uniprot IDs		Q9Y4D2	Q3ZAQ7
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Myelin Sheath Membrane Membrane Raft Establishment Of Protein Localization To Membrane Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Protein Insertion Into Membrane Myelination Apical Plasma Membrane Axon Ensheathment Membrane Raft Polarization Apical Plasma Membrane Urothelial Plaque B-1a B Cell Differentiation Protein Localization To Paranode Region Of Axon B-1 B Cell Differentiation Localization Within Membrane Membrane Raft Distribution Peptidase Activator Activity Involved In Apoptotic Process Sensory Perception Of Sound TIM22 Mitochondrial Import Inner Membrane Insertion Complex Sensory Perception Of Mechanical Stimulus Mitochondrial Intermembrane Space Chaperone Complex Vacuolar Proton-transporting V-type ATPase Complex Assembly Proton-transporting V-type ATPase Complex Assembly Glucose Import In Response To Insulin Stimulus	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Membrane Organization Endoplasmic Reticulum Monoacylglycerol Lipase Activity Lipid Biosynthetic Process Acylglycerol Metabolic Process Neutral Lipid Metabolic Process Establishment Of Protein Localization To Membrane Craniofacial Suture Morphogenesis Myelination Axon Ensheathment Acylglycerol Catabolic Process Nitrate Transmembrane Transporter Activity SNAP Receptor Activity Lipid Metabolic Process Glycerolipid Metabolic Process Monounsaturated Fatty Acid Biosynthetic Process CDP-diacylglycerol-inositol 3-phosphatidyltransferase Activity Extraction Of Mislocalized Protein From ER Membrane ABC-type Manganese Transporter Activity Membrane Protein Dislocase Activity
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