DAGLA

Name	diacylglycerol lipase alpha
Structure	No pdb structure
Novel Interactors	1 novel interactors: TIMM10
Interactors	10 interactors: CMTM7 LHFPL5 MAL MALL MS4A13 STOM TMEM218 TRARG1 UPK1B VMA21
GO Annotations	Cellular Component	Cytoplasm Endosome Plasma Membrane Membrane Early Endosome Membrane Dendrite Membrane Dendritic Spine Membrane Cell Projection Varicosity Synapse Postsynaptic Membrane Postsynaptic Density Membrane
	Molecular Function	Lipoprotein Lipase Activity Protein Binding Hydrolase Activity Metal Ion Binding Monoacylglycerol Lipase Activity
	Biological Process	Lipid Metabolic Process Acylglycerol Metabolic Process Monoacylglycerol Biosynthetic Process Neuroblast Proliferation Lipid Catabolic Process Arachidonate Metabolic Process Neurogenesis Diacylglycerol Catabolic Process Retrograde Trans-synaptic Signaling By Endocannabinoid Regulation Of Neuroinflammatory Response Cannabinoid Biosynthetic Process
Pathways	Arachidonate production from DAG
GWAS	Bipolar disorder ( 28115744 31043756 ) Fasting plasma glucose ( 32902719 ) Immune reponse to smallpox (secreted IL-2) ( 22610502 ) Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid) ( 21829377 ) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377 ) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311 ) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311 ) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311 ) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311 ) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311 ) Red blood cell fatty acid levels ( 25500335 ) Refractive error ( 32231278 )
Entrez ID	747
HPRD ID	07092
Ensembl ID	ENSG00000134780
Uniprot IDs	Q9Y4D2
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Structural Constituent Of Myelin Sheath Membrane Membrane Raft Establishment Of Protein Localization To Membrane Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Protein Insertion Into Membrane Myelination Apical Plasma Membrane Axon Ensheathment Membrane Raft Polarization Apical Plasma Membrane Urothelial Plaque B-1a B Cell Differentiation Protein Localization To Paranode Region Of Axon B-1 B Cell Differentiation Localization Within Membrane Membrane Raft Distribution Peptidase Activator Activity Involved In Apoptotic Process Sensory Perception Of Sound TIM22 Mitochondrial Import Inner Membrane Insertion Complex Sensory Perception Of Mechanical Stimulus Mitochondrial Intermembrane Space Chaperone Complex Vacuolar Proton-transporting V-type ATPase Complex Assembly Proton-transporting V-type ATPase Complex Assembly Glucose Import In Response To Insulin Stimulus