CRHBP and ERRFI1

Number of citations of the paper that reports this interaction (PubMedID 20351267)
44

Data Source:
BioGRID (two hybrid)

		CRHBP	ERRFI1
Description		corticotropin releasing hormone binding protein	ERBB receptor feedback inhibitor 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Secondary Lysosome Multivesicular Body Endoplasmic Reticulum Golgi Apparatus Microtubule Secretory Granule Dendrite Dense Core Granule Varicosity Perikaryon Axon Terminus	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding Peptide Binding Corticotropin-releasing Hormone Binding	GTPase Activator Activity Protein Binding SH3 Domain Binding Kinase Binding Protein Kinase Binding Small GTPase Binding
	Biological Process	Synaptic Transmission, Dopaminergic Maternal Aggressive Behavior Inflammatory Response Signal Transduction Female Pregnancy Learning Or Memory Hormone-mediated Signaling Pathway Cellular Response To Potassium Ion Hormone Metabolic Process Regulated Exocytosis Behavioral Response To Ethanol Regulation Of Corticotropin Secretion Negative Regulation Of Corticotropin Secretion Cellular Response To Calcium Ion Cellular Response To Cocaine Cellular Response To CAMP Cellular Response To Tumor Necrosis Factor Cellular Response To Estrogen Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Xenobiotic Stimulus Regulation Of Cellular Response To Stress Cellular Response To Gonadotropin-releasing Hormone Negative Regulation Of Corticotropin-releasing Hormone Receptor Activity Regulation Of NMDA Receptor Activity	Skeletal System Development Liver Development Tissue Homeostasis Glucose Metabolic Process Lipid Metabolic Process Bile Acid Biosynthetic Process Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Embryo Implantation Cholesterol Metabolic Process Response To Xenobiotic Stimulus Gene Expression Cell Migration Negative Regulation Of Protein Autophosphorylation Response To Estradiol Response To Progesterone Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Tumor Necrosis Factor Production Response To Insulin Cellular Response To Insulin Stimulus Negative Regulation Of Collagen Biosynthetic Process Uterine Epithelium Development Chondrocyte Proliferation Limb Joint Morphogenesis Cellular Response To Platelet-derived Growth Factor Stimulus Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cholesterol Homeostasis Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Skin Development Skin Morphogenesis Regulation Of Keratinocyte Differentiation Lung Alveolus Development Response To Steroid Hormone Epithelial Cell Proliferation Progesterone Receptor Signaling Pathway Cartilage Development Uterus Development Lung Vasculature Development Lung Epithelium Development Epithelium Development Fat Pad Development Regulation Of Type B Pancreatic Cell Proliferation Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Cellular Hyperosmotic Response Cellular Response To Dexamethasone Stimulus Protein Localization To Plasma Membrane Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Response To 1-oleoyl-sn-glycerol 3-phosphate
Pathways		Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Chronotype ( 30696823) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690)	Crohn's disease ( 28067908) Hair shape ( 29220522) HDL cholesterol levels in HIV infection ( 33109212) Inflammatory bowel disease ( 28067908) Ischemic stroke ( 24262325) Morning person ( 30696823) Response to antidepressants and depression ( 27622933) Strep throat ( 28928442) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		2 interacting genes: ERRFI1 UCN	58 interacting genes: ACBD3 ADAM5 AGPAT4-IT1 AOX1 ARRDC5 ATM AURKA BAG4 BCAR3 CASP8 CDC42 CIAO2B COPS5 CRHBP DCTN6 EFEMP1 EGFR ERBB2 FGFR2 FGFR4 GAS1 GNPDA2 GTF2H2 HYDIN IL2RG MMP26 NEDD4 NEU1 NPC2 OSTF1 PALB2 PAPSS1 PCCA PCNA PDCD2 PHYHIPL PLEKHA3 PPIA PPM1D PSMA7 PSMB6 RAB18 RB1CC1 RUBCNL SH3YL1 SKIC8 SLC61A1 SLC7A13 SMIM30 SRC TC2N TIMP4 TM2D3 TMEM165 TMEM59 WEE1 YWHAB ZPBP
Entrez ID		1393	54206
HPRD ID		08348	09218
Ensembl ID		ENSG00000145708	ENSG00000116285
Uniprot IDs		P24387	B3KTV8 I6S2Y9 Q9UJM3
PDB IDs			2RF9 2RFD 2RFE 4I21 4R3P 4R3R 4ZJV
Enriched GO Terms of Interacting Partners?		Regulation Of Collagen Metabolic Process Regulation Of Collagen Biosynthetic Process Response To Methotrexate Dihydrofolate Reductase Activity Transport Of Viral Material Towards Nucleus Intracellular Transport Of Viral Protein In Host Cell Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Response To Estradiol Histone Deacetylase Inhibitor Activity Response To Glucocorticoid Response To Corticosteroid Uterine Epithelium Development Response To 1-oleoyl-sn-glycerol 3-phosphate Dihydrofolate Metabolic Process Folic Acid Binding Folic Acid-containing Compound Biosynthetic Process Alcohol Metabolic Process Tetrahydrofolate Biosynthetic Process Tetrahydrobiopterin Metabolic Process Regulation Of Removal Of Superoxide Radicals Regulation Of Response To Reactive Oxygen Species Negative Regulation Of Gene Expression Regulation Of Protein Metabolic Process Folic Acid Metabolic Process Tetrahydrobiopterin Biosynthetic Process Host Cell Intracellular Transport Of Virus Secretory Vesicle Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Corticotropin Secretion Positive Regulation Of Behavioral Fear Response Varicosity Positive Regulation Of Fear Response Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of Appetite Corticotropin-releasing Hormone Receptor 1 Binding Regulation Of Behavioral Fear Response Regulation Of Corticotropin Secretion Regulation Of Muscle System Process Negative Regulation Of Cell Size Negative Regulation Of Feeding Behavior Corticotropin-releasing Hormone Receptor 2 Binding Drinking Behavior Response To Steroid Hormone Negative Regulation Of Protein Autophosphorylation Skin Morphogenesis Negative Regulation Of Signaling Receptor Activity Oviduct Epithelium Development Lung Vasculature Development Limb Joint Morphogenesis	Peptidyl-tyrosine Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Protein Tyrosine Kinase Activity Enzyme Binding ERBB Signaling Pathway Positive Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Activity Protein Autophosphorylation Regulation Of MAPK Cascade ERBB2 Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Fibroblast Growth Factor Receptor Activity Protein Phosphorylation Phosphoserine Residue Binding Kinase Activity Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Phosphorylation Protein Kinase Activity ERBB2-EGFR Signaling Pathway Cellular Response To Growth Factor Stimulus Ruffle Membrane Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Positive Regulation Of DNA Replication Positive Regulation Of DNA Biosynthetic Process Animal Organ Development Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Response To Estradiol Endothelin Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Epidermal Growth Factor Stimulus Receptor Complex Response To Epidermal Growth Factor Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Response To Growth Factor Progesterone Receptor Signaling Pathway G2/M Transition Of Mitotic Cell Cycle Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cis-Golgi Network Membrane Cell Cycle G2/M Phase Transition DNA Repair Complex
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