UBC and FOXO3

Number of citations of the paper that reports this interaction (PMID 18204439)
123

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology)

		UBC	FOXO3
Gene Name		ubiquitin C	forkhead box O3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane Endosome Membrane Endocytic Vesicle Membrane Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	Protease Binding Protein Binding Poly(A) RNA Binding	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Binding Transcription Cofactor Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Kinase Binding Chromatin DNA Binding Sequence-specific DNA Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPK Activity Protein Polyubiquitination Mitotic Cell Cycle Toll-like Receptor Signaling Pathway Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Carbohydrate Metabolic Process Glycogen Biosynthetic Process Glucose Metabolic Process DNA Repair Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Notch Receptor Processing I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Circadian Rhythm Fibroblast Growth Factor Receptor Signaling Pathway Pathogenesis Gene Expression Viral Process Endosomal Transport Viral Life Cycle Virion Assembly Viral Protein Processing Cytokine-mediated Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Type I Interferon Production Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Ion Transmembrane Transport TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Small Molecule Metabolic Process Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Transmembrane Transport Membrane Organization Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Response To Hypoxia Intracellular Transport Of Virus Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Apoptotic Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ovulation From Ovarian Follicle Initiation Of Primordial Ovarian Follicle Growth Antral Ovarian Follicle Growth Oocyte Maturation Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Regulation Of Translation Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway DNA Damage Response, Signal Transduction By P53 Class Mediator Cellular Response To Oxidative Stress Fc-epsilon Receptor Signaling Pathway Glucose Homeostasis Positive Regulation Of Neuron Apoptotic Process Innate Immune Response Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Negative Regulation Of Canonical Wnt Signaling Pathway Neuronal Stem Cell Maintenance Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Neural Precursor Cell Proliferation Regulation Of Reactive Oxygen Species Metabolic Process
Pathways			Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Signaling by NODAL Innate Immune System Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR AKT phosphorylates targets in the nucleus Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS			Insulin-like growth factors ( 21216879) Normalized brain volume ( 19010793) Prostate cancer ( 23535732)
Protein-Protein Interactions		491 interactors: ABL1 ADH7 AMPH ANAPC1 ANAPC11 ANAPC7 ANGPTL3 ANKRD30A ANKS1A ANKS1B APC2 APOC3 ARNTL2 ASB11 ASB2 ASMTL ATG16L1 ATXN3 BARX1 BCAS2 BCL10 BIN1 BIRC2 BIRC6 BIRC7 BMS1 BRCA1 BRCC3 BRE BRSK1 BTD C3orf17 C8orf34 CALCOCO2 CBL CBLB CBLC CBR1 CBR3 CCDC149 CCDC50 CCNB1IP1 CCNK CCT4 CD2AP CDH22 CDKN1A CDY1B CENPE CEP164 CEP192 CEP83 CFTR CHCHD2 CHERP CHGA CITED2 CKMT1A CLN8 CNOT4 CNTLN CNTRL CP CPB2 CRTC2 CSMD3 CTRC CUEDC2 CUL4B CUL9 CYP3A4 DAZAP2 DDX42 DDX58 DECR2 DENR DHFR DLGAP4 DMBX1 DMRT2 DNAH7 DNASE2B DNHD1 DOCK6 DPP9 DYNC1I1 DYRK2 DZIP3 ECE2 EFS EHMT1 EIF3C EIF3F ELK1 ELL ENPP7 EPHA8 EPN1 EPN2 ERN1 ERVK13-1 EXOSC8 FAM111A FAM175A FAM175B FBXO16 FBXO18 FBXO44 FETUB FGA FIS1 FOXO3 FSHR GABBR1 GARNL3 GFPT2 GGA1 GGA3 GRAP2 GTF2IRD1 HACE1 HDAC5 HDAC6 HECW1 HENMT1 HERC3 HERC4 HGS HIC1 HIST1H2AI HIST1H4A HIST2H2AC HIST2H2BC HIST2H2BE HIST2H4A HLTF HMCN1 HOXA9 HRNR HSPA8 HYDIN HYDIN2 IDE IGF1R IKBKG IL17B IRF1 ISX ITCH JOSD2 KCNJ1 KCTD6 KDM2A KDR KEL KIAA0586 KIAA1211 KLHL11 KLHL13 KLHL6 KLHL7 KMT2D L1CAM LALBA LAPTM5 LARP1B LIMA1 LOC100130417 LOC100272216 LTN1 LYZ MAD1L1 MAN1A2 MAP3K11 MAP3K2 MAP3K3 MAPK4 MAPT MARCH7 MARK4 MDFI MDM4 MDN1 MED15 MFRP MINPP1 MMP8 MOAP1 MPHOSPH9 MRPL37 MTERF4 MUC16 MUC5B MUL1 MVB12A MYOCD N4BP1 NAE1 NAV3 NBPF1 NBPF10 NBPF11 NBPF12 NBPF14 NBPF8 NBPF9 NCKAP5L NCOA6 NDC1 NEDD4 NEDD4L NEK8 NEURL3 NHP2 NPLOC4 NR0B2 NR2C1 NT5C1B NUAK1 NUAK2 OBP2B OLFML2A OPRM1 OPTN OR7G3 OTOG OTUB2 OTUD1 OTUD3 OTUD4 OTUD5 OTUD6A OTUD7A OTUD7B OTULIN P4HTM PA2G4 PABPC4 PARK2 PARP10 PARVA PBLD PCNP PDE12 PDS5A PELI1 PHF20L1 PINK1 PJA1 PJA2 PLAA POLH POLI POLR2A POP5 PPARG PPARGC1A PPL PPM1D PPP1R13B PRAME PRKCI PRKDC PRPF8 PRR23B PSMC2 PSMC3 PSMD1 PSMD4 PTH1R PTOV1 PUS7L R3HDM4 RABEP1 RABEP2 RABGEF1 RAD18 RAD51B RAF1 RARRES3 RASAL2 RB1CC1 RELA RGPD3 RGS2 RIOK3 RND3 RNF11 RNF111 RNF112 RNF114 RNF125 RNF130 RNF167 RNF168 RNF169 RNF181 RNF20 RNF31 RNF4 RNF8 RPL7L1 RTTN SBF2 SCT SDK1 SEC61B SEPT4 SEPT7P2 SF3A1 SF3B1 SF3B4 SFPQ SGOL1 SH3KBP1 SHARPIN SIAH1 SLC17A2 SLC22A18 SLC26A1 SLC35A5 SLC44A3 SLIT2 SLX4 SMAD1 SMURF1 SMURF2 SNCA SNRNP25 SNRPA SNTB2 SNTG1 SOCS5 SPAG1 SPARCL1 SPECC1L SPTA1 SQSTM1 ST5 STAM STAM2 STAMBP STAT1 STAT4 STX8 SUCO SUN5 SUOX SYNE2 TAB2 TAB3 TAC3 TACC2 TAX1BP1 TBXAS1 TCHH TCP10 THG1L TIAM1 TLR8 TMEM132A TMEM160 TNFAIP3 TNFAIP6 TNIP1 TNIP2 TNIP3 TOLLIP TOM1 TOM1L2 TOPORS TRA TRAFD1 TRIM17 TRIM21 TRIM23 TRIM36 TRIM39 TRIM41 TRIM49B TRIM5 TRIM58 TRIM63 TSHR TTC27 TTC28 TTC36 TTC39B TTLL5 TUBA3D TUBGCP2 TYW1 UBA1 UBA2 UBA3 UBAP1 UBASH3A UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2G2 UBE2J2 UBE2K UBE2L3 UBE2L6 UBE2M UBE2N UBE2R2 UBE2S UBE2V1 UBE2V2 UBE3A UBE3C UBFD1 UBL7 UBQLN1 UBR1 UBR3 UBR4 UBR5 UCHL1 UCHL3 UEVLD UNC79 UNC93B3 USP1 USP10 USP11 USP12 USP13 USP14 USP15 USP16 USP17L2 USP19 USP2 USP21 USP22 USP25 USP28 USP3 USP33 USP4 USP46 USP48 USP5 USP7 USP8 USP9X USP9Y UTRN VCPIP1 VMP1 VPS36 VPS37C VPS9D1 WDR20 WDR88 WFDC8 WNK1 WWP1 WWP2 XIAP XPNPEP1 YBX1 YOD1 YWHAB YWHAG YWHAZ ZBTB1 ZC3H12A ZC3H13 ZC3HC1 ZCWPW2 ZFAND3 ZFAND6 ZFYVE9 ZNF148 ZNF200 ZNF213 ZNF451 ZNF705G ZNF716 ZNF789 ZNF792 ZNRF1 ZRANB1 ZSWIM2 ZW10	24 interactors: AKT1 ATM BTRC CDK6 CDT1 CHUK EP300 ERBB2IP ESR1 FOXG1 IKBKB MAPK1 MAPK6 NR1H2 NR1H3 SGK1 SIRT1 SMAD2 SMAD3 SMAD4 UBC VDR YWHAG YWHAZ
Entrez ID		7316	2309
HPRD ID		07038	04061
Ensembl ID		ENSG00000150991	ENSG00000118689
Uniprot IDs		F5H041 L8B4I8	B4DVZ6 O43524
PDB IDs			2K86 2LQH 2LQI 2UZK
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Modification-dependent Protein Catabolic Process Cellular Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Cellular Protein Modification Process Cellular Macromolecule Catabolic Process Protein Deubiquitination Protein Polyubiquitination Protein Modification By Small Protein Removal Proteolysis Cellular Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Catabolic Process Protein Metabolic Process Cellular Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Protein K63-linked Deubiquitination Regulation Of Proteasomal Protein Catabolic Process Protein K48-linked Ubiquitination Regulation Of Proteolysis Cellular Process Cellular Response To Stress Protein K48-linked Deubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Response To Stress Regulation Of Signal Transduction Cell Cycle Metabolic Process Protein K63-linked Ubiquitination Apoptotic Process Regulation Of Signaling Cell Death Death Cellular Response To Stimulus Positive Regulation Of Metabolic Process Programmed Cell Death Response To Stimulus Cell Cycle Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination	Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Organic Substance Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Regulation Of Signal Transduction DNA-templated Transcription, Initiation Signaling Response To Organic Substance Regulation Of Gene Expression Cellular Response To Stimulus Cell Communication Epithelium Development Regulation Of Signaling Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Signal Transduction Mammary Gland Epithelium Development Intracellular Receptor Signaling Pathway Positive Regulation Of Transport Apoptotic Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Organic Cyclic Compound Negative Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Mammary Gland Epithelial Cell Proliferation Response To Organic Cyclic Compound Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Death Positive Regulation Of Metabolic Process Response To Stimulus Response To Hypoxia Apoptotic Process Mammary Gland Development Regulation Of Immune System Process Gland Development Regulation Of Nitrogen Compound Metabolic Process
Tagcloud ?		3p24 amino assigned bond cdna conjugating drosophila e1 e2 encoding enzyme extension fluorescence formed hybridization identity kb product shares similarity thioester transcribed transcript ubcd2 ubch6 ubch8 ubcm2 ube2e2 ubiquitin	20b 34a 7e actively ccnd ccne1 compromised dysregulated enterotoxin exacerbation infiltrating let lungs mir mirna orchestrating participating pertaining poisoning ptgs2 runx1 saw seb silico smad3 staphyloccocal stringent tbx21 tgfb
Tagcloud (Difference) ?		3p24 amino assigned bond cdna conjugating drosophila e1 e2 encoding enzyme extension fluorescence formed hybridization identity kb product shares similarity thioester transcribed transcript ubcd2 ubch6 ubch8 ubcm2 ube2e2 ubiquitin	20b 34a 7e actively ccnd ccne1 compromised dysregulated enterotoxin exacerbation infiltrating let lungs mir mirna orchestrating participating pertaining poisoning ptgs2 runx1 saw seb silico smad3 staphyloccocal stringent tbx21 tgfb
Tagcloud (Intersection) ?