PRR20B and TBX6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PRR20B	TBX6
Description		proline rich 20B	T-box transcription factor 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Chromatin Nucleus
	Molecular Function		RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Mesoderm Formation Cell Fate Specification Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Mesoderm Development Mesodermal Cell Fate Specification Anatomical Structure Morphogenesis Negative Regulation Of Neuron Projection Development Negative Regulation Of Neuron Maturation Signal Transduction Involved In Regulation Of Gene Expression Somite Rostral/caudal Axis Specification Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways			Formation of paraxial mesoderm Somitogenesis Formation of the posterior neural plate
Drugs
Diseases
GWAS		Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269)	Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Eosinophil count ( 27863252 32888494) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Multiple sclerosis ( 31604244) Red blood cell count ( 29403010 27863252 32888494) Reticulocyte count ( 32888494) Schizophrenia ( 29483656 25056061) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		89 interacting genes: ABI2 ANKHD1 ARID5A ATXN1 BANP BEND2 BHLHE40 BICRAL C10orf55 C1orf94 C3orf36 CABP2 CCNK CDC37 CELF4 DAZAP2 DMRT3 DVL3 EIF4ENIF1 ESRP1 FAM168A FAM222B FAM9A FOXH1 FOXP3 GLIS2 GTF2A1 HIVEP1 HLX HYPK KRTAP19-1 KRTAP19-5 LASP1 MAGED1 MBNL3 NCK2 NFYC NOTCH3 NTAQ1 OXER1 PATZ1 PHF1 PITX1 POGZ POU2F1 POU6F2 PRR20A PRR20C PRR20D PRR20E PRR34 PRR35 PTTG2 RBM23 RBM42 RBPMS RBPMS2 RHOXF2 RIPPLY1 RNF4 ROR2 SAMD11 SH3RF1 SIAH1 SMAP1 SNRPB SNRPC SP4 SRPK2 TBX3 TBX6 TCF7L2 TFG THAP1 TIAL1 TLX3 TOLLIP TPRX1 TRIM35 VAC14 VENTX VEZF1 VPS37C YPEL3 ZBTB32 ZC3H10 ZCCHC14 ZNF385C ZNF683	39 interacting genes: ACTMAP C10orf55 C1orf94 CRX CYSRT1 DAZAP2 HSFY1 HSFY2 INTS11 KLHDC7B KRTAP11-1 KRTAP13-1 KRTAP6-2 KRTAP6-3 MAGED1 MEOX2 METTL27 MGAT5B PLA2G10 POU2AF1 POU6F2 PRMT1 PRR20A PRR20B PRR20C PRR20D PRR20E PSMA3 RBPMS TBX15 TBX19 TCP11L1 TENT5B TLE5 TOX4 TSC1 USP54 YPEL3 ZNF34
Entrez ID		729233	6911
HPRD ID		19668	03888
Ensembl ID		ENSG00000204918	ENSG00000149922
Uniprot IDs		P86478 P86479 P86480 P86481 P86496	O95947
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process DNA Binding Nucleus Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Protein Binding Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Splicing Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Regulation Of MRNA Splicing, Via Spliceosome Sequence-specific DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Binding Sequence-specific Double-stranded DNA Binding Negative Regulation Of Biosynthetic Process Regulation Of MRNA Processing Myoblast Fate Commitment Nucleoplasm Identical Protein Binding Regulation Of MRNA Metabolic Process MRNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Metabolic Process Embryonic Axis Specification U1 SnRNP Binding
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