DNLZ and HSPA9

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		DNLZ	HSPA9
Description		DNL-type zinc finger	heat shock protein family A (Hsp70) member 9
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Cytosol	SAM Complex Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Inner Membrane TIM23 Mitochondrial Import Inner Membrane Translocase Complex Mitochondrial Matrix Focal Adhesion Mitochondrial Nucleoid Extracellular Exosome MIB Complex
	Molecular Function	Zinc Ion Binding Protein Folding Chaperone Metal Ion Binding Protein-folding Chaperone Binding	Nucleotide Binding RNA Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Folding Chaperone Unfolded Protein Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Protein Folding Protein Import Into Mitochondrial Matrix Protein Stabilization Chaperone-mediated Protein Complex Assembly	Protein Folding Protein Export From Nucleus Intracellular Protein Transport Inner Mitochondrial Membrane Organization Iron-sulfur Cluster Assembly Erythrocyte Differentiation Calcium Import Into The Mitochondrion Protein Refolding Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Erythrocyte Differentiation Negative Regulation Of Erythrocyte Differentiation Negative Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Hemopoiesis
Pathways			Mitochondrial protein import Regulation of HSF1-mediated heat shock response Complex I biogenesis Cristae formation Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Mitochondrial protein degradation Mitochondrial unfolded protein response (UPRmt) Complex III assembly
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) Fasting glucose ( 34059833) FEV1 ( 30804560) Glycated hemoglobin levels ( 34059833) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Joint damage in rheumatoid arthritis ( 26498133) Lung function (FVC) ( 28166213 30804560) Peak insulin response (insulin secretion adjusted) ( 28490609) Ulcerative colitis ( 28067908)	Autism spectrum disorder or schizophrenia ( 28540026) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Schizophrenia ( 25056061 29483656)
Interacting Genes		1 interacting genes: HSPA9	31 interacting genes: APP DNAJC19 DNLZ ERBB2 ERCC6 FGF1 HSP90B1 HSPBP1 LAMTOR5 LCOR LINC01554 LSM8 MATK MVD NEDD8 NELFB OGT PTPN11 PTPRF RNF10 RNF26 SIRPA STUB1 SUMO2 SUMO4 SUPT6H TP53 USP7 XPO1 YKT6 YWHAG
Entrez ID		728489	3313
HPRD ID		19082	02770
Ensembl ID		ENSG00000213221	ENSG00000113013
Uniprot IDs		Q5SXM8	A0A384P5G6 P38646
PDB IDs			3N8E 4KBO 6NHK 6P2U 6PMT 9BLS 9BLT 9BLU
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Hematopoietic Progenitor Cell Differentiation TIM23 Mitochondrial Import Inner Membrane Translocase Complex MIB Complex Negative Regulation Of Erythrocyte Differentiation SAM Complex Calcium Import Into The Mitochondrion Negative Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of Hematopoietic Stem Cell Differentiation Mitochondrial Calcium Ion Transmembrane Transport Negative Regulation Of Stem Cell Differentiation Iron-sulfur Cluster Assembly Protein Refolding Protein Export From Nucleus Inner Mitochondrial Membrane Organization ATP-dependent Protein Folding Chaperone Regulation Of Hematopoietic Progenitor Cell Differentiation Mitochondrial Nucleoid Regulation Of Erythrocyte Differentiation Protein Folding Chaperone Heat Shock Protein Binding Erythrocyte Differentiation Regulation Of Stem Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Unfolded Protein Binding Mitochondrial Membrane Organization Negative Regulation Of Hemopoiesis Nuclear Export Calcium Ion Transmembrane Transport Protein Folding Regulation Of Myeloid Cell Differentiation Nuclear Transport Nucleocytoplasmic Transport Mitochondrion Organization Calcium Ion Transport Myeloid Cell Differentiation Negative Regulation Of Cell Development	Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Growth Factor Activity Regulation Of Phosphorus Metabolic Process Protein Modification Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Protein Tag Activity Regulation Of Proteasomal Protein Catabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Protein Localization To Organelle Regulation Of Protein Metabolic Process Regulation Of Macromolecule Biosynthetic Process Receptor Tyrosine Kinase Binding Protein Modification By Small Protein Conjugation TORC1 Signaling Regulation Of Protein Catabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Protein-containing Complex Positive Regulation Of Gene Expression Regulation Of Purine Nucleotide Metabolic Process TOR Signaling Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Metabolic Process Intracellular Protein Localization Post-translational Protein Modification Regulation Of Cell Activation Regulation Of TORC1 Signaling Regulation Of Small Molecule Metabolic Process Positive Regulation Of Proteolysis Protein-folding Chaperone Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Component Organization Cellular Response To Oxygen-containing Compound Regulation Of DNA-templated Transcription Response To Stress Regulation Of RNA Biosynthetic Process Cytokine Activity Regulation Of Protein Localization Positive Regulation Of Cell Population Proliferation Regulation Of Lymphocyte Activation Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Protein Metabolic Process Developmental Growth Protein Stabilization Positive Regulation Of Cell Activation Cellular Response To Manganese Ion
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