GTF2H2C and NR5A2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GTF2H2C	NR5A2
Description		GTF2H2 family member C	nuclear receptor subfamily 5 group A member 2
Image		No pdb structure
GO Annotations	Cellular Component	Transcription Factor TFIIH Core Complex Nucleus Transcription Factor TFIIH Holo Complex Nuclear Speck	Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Phospholipid Binding Zinc Ion Binding Lipid Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA Repair Nucleotide-excision Repair DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response	Primary Ovarian Follicle Growth Inner Cell Mass Cell Differentiation Positive Regulation Of T Cell Anergy Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Spermatogenesis Bile Acid Metabolic Process Hormone-mediated Signaling Pathway Embryo Development Ending In Birth Or Egg Hatching Tissue Development Neurogenesis Intracellular Receptor Signaling Pathway Exocrine Pancreas Development Positive Regulation Of Glucocorticoid Biosynthetic Process Negative Regulation Of Chondrocyte Differentiation Somatic Stem Cell Population Maintenance Embryonic Cleavage Positive Regulation Of T Cell Proliferation Regulation Of Cell Population Proliferation Homeostatic Process Cholesterol Homeostasis Positive Regulation Of Viral Genome Replication Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of T Cell Activation Cartilage Development Sertoli Cell Development Pancreas Morphogenesis Acinar Cell Differentiation Calcineurin-mediated Signaling Morula Formation Zygotic Genome Activation Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Stem Cell Differentiation Positive Regulation Of Tendon Cell Differentiation
Pathways			Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Diffusing capacity of carbon monoxide ( 30694715)	Age at voice drop ( 27182965) Cerebrospinal T-tau levels ( 28247064) Cervical high-risk human papilloma virus infection (persistent) ( 33225922) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) FEV1 ( 30804560) Gamma glutamyl transferase levels ( 29403010 33339817) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hepcidin/transferrin saturation ratio ( 27846281) Hyperinsulinemia in obesity ( 30327367) Hyperinsulinemia x BMI interaction ( 30327367) Inflammatory bowel disease ( 28067908) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Length of menstrual cycle ( 30202859) Lung adenocarcinoma ( 28604730) Lung function (FVC) ( 30804560 30061609) Menarche (age at onset) ( 25231870) Myopia ( 27182965) Nicotine dependence ( 28440896) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Pancreatic cancer ( 29422604 20101243 25086665 27579533 26098869) Refractive error ( 32231278) Rheumatoid arthritis ( 25014791) Ulcerative colitis ( 28067908) Uric acid levels ( 21294900) Urinary albumin excretion ( 30220432)
Interacting Genes		3 interacting genes: FAM43A NR5A2 NTAQ1	24 interacting genes: ALB BCKDK CTNNB1 DDB2 EDF1 FTH1 GTF2H2C HSP90B1 NCOA1 NCOA3 NPPA NR0B2 NR1I2 NRIP1 NSD1 PNRC1 PNRC2 POLR2D PROX1 RAD54L2 RANBP2 SMARCD3 SREBF1 UBE2I
Entrez ID		728340	2494
HPRD ID		19371	06830
Ensembl ID		ENSG00000183474	ENSG00000116833
Uniprot IDs		Q6P1K8	F1D8R9 O00482
PDB IDs			1YOK 1YUC 1ZDU 2A66 3PLZ 3TX7 4DOR 4DOS 4IS8 4ONI 4PLD 4PLE 4RWV 5L0M 5L11 5SYZ 5UNJ 6OQX 6OQY 6OR1 6VC2 6VIF 7JYD 7JYE 7TT8 8F8M 8PKI
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Glucocorticoid Biosynthetic Process Positive Regulation Of Tendon Cell Differentiation Primary Ovarian Follicle Growth Zygotic Genome Activation Protein-N-terminal Asparagine Amidohydrolase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Morula Formation Pancreas Morphogenesis Acinar Cell Differentiation Inner Cell Mass Cell Differentiation Positive Regulation Of T Cell Anergy Positive Regulation Of Steroid Hormone Biosynthetic Process Regulation Of Glucocorticoid Biosynthetic Process Exocrine Pancreas Development Positive Regulation Of Hormone Biosynthetic Process Regulation Of T Cell Anergy Embryonic Cleavage Positive Regulation Of T Cell Tolerance Induction Positive Regulation Of Tolerance Induction Regulation Of Glucocorticoid Metabolic Process Regulation Of T Cell Tolerance Induction Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Regulation Of Steroid Hormone Biosynthetic Process Sertoli Cell Development Regulation Of Tolerance Induction Regulation Of Hormone Biosynthetic Process Positive Regulation Of Stem Cell Differentiation Negative Regulation Of Chondrocyte Differentiation Glandular Epithelial Cell Differentiation Calcineurin-mediated Signaling Positive Regulation Of Viral Genome Replication Negative Regulation Of Cartilage Development Bile Acid Metabolic Process Regulation Of Hormone Metabolic Process Positive Regulation Of Steroid Biosynthetic Process Ovulation Cycle Process Transcription Coregulator Binding Positive Regulation Of Steroid Metabolic Process Nuclear Receptor Activity Regulation Of Chondrocyte Differentiation	Nuclear Receptor Binding Nuclear Retinoid X Receptor Binding Nuclear Retinoic Acid Receptor Binding Nucleus Nuclear Estrogen Receptor Binding Transcription Coregulator Binding Protein-containing Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Transcription Coregulator Activity Positive Regulation Of RNA Metabolic Process Transcription Coactivator Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleoplasm Nuclear Thyroid Hormone Receptor Binding Acinar Cell Differentiation Regulation Of Metabolic Process SUMO Ligase Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Receptor Signaling Pathway Response To Estradiol Regulation Of Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Regulation Of Primary Metabolic Process Rhythmic Process Regulation Of Neuroblast Proliferation Negative Regulation Of Transcription By RNA Polymerase II Circadian Rhythm Regulation Of RNA Metabolic Process Transcription By RNA Polymerase II Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Neuron Fate Determination Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Protein-containing Complex Binding Nucleobase-containing Compound Biosynthetic Process Lens Morphogenesis In Camera-type Eye Hypothalamus Development Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Macromolecule Metabolic Process SUMO Transferase Activity
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