TUBB1

Gene Name		tubulin, beta 1 class VI
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Microtubule Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Structural Constituent Of Cytoskeleton GTP Binding
	Biological Process	Protein Folding Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Spindle Assembly Protein Polymerization Transmembrane Transport
Pathways		Transport of connexons to the plasma membrane Mitotic Prometaphase Organelle biogenesis and maintenance Axon guidance Hedgehog 'off' state Separation of Sister Chromatids Translocation of GLUT4 to the plasma membrane G2/M Transition L1CAM interactions Mitotic Anaphase Recycling pathway of L1 Recruitment of NuMA to mitotic centrosomes Formation of tubulin folding intermediates by CCT/TriC Intraflagellar transport M Phase Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Post-chaperonin tubulin folding pathway Gap junction trafficking and regulation MHC class II antigen presentation Recruitment of mitotic centrosome proteins and complexes Orphan transporters Protein folding Gap junction assembly Gap junction trafficking Kinesins Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Assembly of the primary cilium Factors involved in megakaryocyte development and platelet production Cell Cycle, Mitotic Resolution of Sister Chromatid Cohesion Chaperonin-mediated protein folding Signaling by Hedgehog Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs		Vindesine Paclitaxel Docetaxel Colchicine Epothilone D Epothilone B Cabazitaxel
Diseases
GWAS		Mean platelet volume ( 22139419 22423221)
Protein-protein Interactions		1 interactors: TTK
Entrez ID		81027
HPRD ID		18243
Ensembl ID		ENSG00000101162
Uniprot IDs		Q9H4B7
PDB IDs
Enriched GO Terms of Interacting Partners?		Chromosome Separation Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Mitotic Spindle Organization Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Negative Regulation Of Chromosome Organization Negative Regulation Of Protein Catabolic Process Regulation Of Mitotic Nuclear Division Spindle Organization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Checkpoint Regulation Of Proteasomal Protein Catabolic Process Regulation Of Chromosome Organization Negative Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Chromosome Segregation Cell Cycle Checkpoint Regulation Of Cell Cycle Phase Transition Regulation Of Cell Division Peptidyl-tyrosine Phosphorylation Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Protein Catabolic Process Regulation Of Protein Processing Regulation Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Process
Tagcloud ?		3435tt abcb1 actg1 ala310 capg carriers childhood cyp3a5 disrupt influencing lymphoblastic map4 microtubules mitotic neuropathy neurotoxicity nucleotides polymorphisms rs1135989 rs3770102 rs4728709 seventeen spindle start substitution synonymous variation vcr vincristine