TP53 and HDAC3

Number of citations of the paper that reports this interaction (PMID 10777477)
81

Data Source:
HPRD (in vivo, in vitro)

		TP53	HDAC3
Gene Name		tumor protein p53	histone deacetylase 3
Image
Gene Ontology Annotations	Cellular Component	Chromatin Nuclear Chromatin Nucleus Nucleoplasm Replication Fork Transcription Factor TFIID Complex Nucleolus Cytoplasm Mitochondrion Mitochondrial Matrix Endoplasmic Reticulum Cytosol Nuclear Matrix Nuclear Body PML Body Protein Complex	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Spindle Microtubule Plasma Membrane Transcriptional Repressor Complex
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Factor Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protease Binding P53 Binding DNA Binding Chromatin Binding Damaged DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Copper Ion Binding Protein Binding ATP Binding Transcription Factor Binding Zinc Ion Binding Enzyme Binding Protein Kinase Binding Protein Phosphatase Binding Receptor Tyrosine Kinase Binding Ubiquitin Protein Ligase Binding Histone Deacetylase Regulator Activity Histone Acetyltransferase Binding Identical Protein Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity Protein N-terminus Binding Chaperone Binding Protein Phosphatase 2A Binding MDM2/MDM4 Family Protein Binding	Chromatin Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Transcription Factor Binding Enzyme Binding Cyclin Binding Chromatin DNA Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Histone Deacetylase Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)
	Biological Process	Protein Import Into Nucleus, Translocation Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Strand Renaturation In Utero Embryonic Development Somitogenesis Release Of Cytochrome C From Mitochondria T Cell Proliferation Involved In Immune Response B Cell Lineage Commitment T Cell Lineage Commitment Response To Ischemia Base-excision Repair Nucleotide-excision Repair Double-strand Break Repair Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Protein Complex Assembly Apoptotic Process Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator ER Overload Response Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Ras Protein Signal Transduction Multicellular Organismal Development Gastrulation Negative Regulation Of Neuroblast Proliferation Cell Aging Blood Coagulation Protein Localization Negative Regulation Of DNA Replication Cell Proliferation Negative Regulation Of Cell Proliferation Determination Of Adult Lifespan RRNA Transcription Response To Salt Stress Response To X-ray Response To Gamma Radiation Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Viral Process Cerebellum Development Cell Differentiation Negative Regulation Of Cell Growth DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Histone Deacetylation Chromatin Assembly Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Protein Oligomerization T Cell Differentiation In Thymus Regulation Of Tissue Remodeling Cellular Protein Localization Cellular Response To UV Multicellular Organism Growth Cellular Response To Drug Positive Regulation Of Mitochondrial Membrane Permeability Cellular Response To Glucose Starvation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Entrainment Of Circadian Clock By Photoperiod Mitochondrial DNA Repair Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Antibiotic Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Fibroblast Proliferation Circadian Behavior Embryonic Organ Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Helicase Activity Protein Tetramerization Neuron Apoptotic Process Positive Regulation Of Thymocyte Apoptotic Process Necroptotic Process Positive Regulation Of Cell Cycle Arrest Cellular Response To Hypoxia Cellular Response To Ionizing Radiation Mitotic Cell Cycle Arrest Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Cell Aging Replicative Senescence Oxidative Stress-induced Premature Senescence Intrinsic Apoptotic Signaling Pathway Oligodendrocyte Apoptotic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Macromitophagy Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Phosphorylation Chromatin Organization Transcription, DNA-templated Protein Deacetylation Notch Signaling Pathway Regulation Of Mitotic Cell Cycle Circadian Rhythm Negative Regulation Of Myotube Differentiation Chromatin Modification Regulation Of Protein Stability Positive Regulation Of TOR Signaling Circadian Regulation Of Gene Expression Regulation Of Multicellular Organism Growth Positive Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Apoptotic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of JNK Cascade Neurotrophin TRK Receptor Signaling Pathway Spindle Assembly Histone H3-K9 Modification Histone H3 Deacetylation Histone H4 Deacetylation Cellular Response To Fluid Shear Stress
Pathways		Cellular Senescence Activation of BH3-only proteins p53-Dependent G1/S DNA damage checkpoint Oncogene Induced Senescence p53-Dependent G1 DNA Damage Response Formation of Senescence-Associated Heterochromatin Foci (SAHF) Pre-NOTCH Transcription and Translation Stabilization of p53 Transcriptional activation of p53 responsive genes Programmed Cell Death Pre-NOTCH Expression and Processing G1/S DNA Damage Checkpoints Intrinsic Pathway for Apoptosis Transcriptional activation of cell cycle inhibitor p21 DNA Damage/Telomere Stress Induced Senescence Signaling by NOTCH Factors involved in megakaryocyte development and platelet production Activation of NOXA and translocation to mitochondria Oxidative Stress Induced Senescence Autodegradation of the E3 ubiquitin ligase COP1 Activation of PUMA and translocation to mitochondria Cell Cycle Checkpoints	Signaling by NOTCH1 HD Domain Mutants in Cancer PPARA activates gene expression Organelle biogenesis and maintenance Metabolism of lipids and lipoproteins Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer RORA activates circadian gene expression Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH1 Transcriptional regulation of white adipocyte differentiation Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Signalling by NGF Fatty acid, triacylglycerol, and ketone body metabolism Chromatin organization p75NTR negatively regulates cell cycle via SC1 HDACs deacetylate histones Signaling by NOTCH p75 NTR receptor-mediated signalling REV-ERBA represses gene expression Mitochondrial biogenesis NOTCH1 Intracellular Domain Regulates Transcription Chromatin modifying enzymes Signaling by NOTCH1 PEST Domain Mutants in Cancer Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis Constitutive Signaling by NOTCH1 PEST Domain Mutants BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS
Protein-Protein Interactions		387 interactors: ABL1 ACTA1 AGT AIMP2 ANK2 ANKRD2 ANXA2 ANXA3 ANXA7 APEX1 APOH APTX ARID1A ARID3A ARIH2 ARL3 ASH2L ATF3 ATM ATR AURKA BACH1 BAIAP2L1 BAK1 BANP BARD1 BCL2 BCL2L1 BCL2L2 BCR BLM BMP1 BRCA1 BRCA2 BRF1 BTBD2 BTK C10orf90 CABLES1 CABLES2 CAPG CAPN1 CARM1 CCDC106 CCL18 CCNA2 CCNG1 CCNH CCT5 CD40LG CDC14A CDC14B CDC25C CDC42 CDK1 CDK2 CDK5 CDK7 CDK8 CDK9 CDKN2C CEBPZ CHD3 CHEK1 CHEK2 CHUK COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 COX17 CR2 CREBBP CSNK1A1 CSNK1D CSNK2A1 CSNK2B CUL9 CXXC1 DAPK3 DAXX DDB1 DDX5 DHCR24 DHFR DLEU1 DNAJC7 DVL2 E2F1 E4F1 EEF2 EFEMP2 EGR1 EHMT1 EHMT2 EIF2AK2 EIF2S2 ELL EP300 EPHA3 ERCC2 ERCC3 ERCC6 ERH ESR1 FAM173A FBXO11 FBXO42 FCAMR FXYD6 FZR1 GADD45A GNL3 GPS1 GPS2 GPX2 GSK3B GSTM4 GTF2H1 GTF2H4 HABP4 HDAC1 HDAC2 HDAC3 HECTD3 HECW1 HERC2 HIF1A HIPK1 HIPK2 HMGB1 HMGB2 HNF4A HNRNPUL1 HSP90AA1 HSP90AB1 HSPA1A HSPA9 HSPB1 HTT HUWE1 IFI16 IKBKB ING1 ING4 ING5 IRF7 ITPK1 KANSL1 KAT2B KAT5 KAT6A KAT7 KAT8 KDM1A KDM4D KIAA0087 KLF4 KLF6 KPNA2 KPNA4 KPNB1 LAMA4 MAD2L1BP MAGEA2 MAGEB18 MAPK1 MAPK10 MAPK14 MAPK3 MAPK8 MAPK9 MAPKAPK5 MCL1 MDC1 MDH1 MDM2 MDM4 MED1 MED17 MED21 MEN1 MIF MNAT1 MNDA MPHOSPH6 MSL2 MSX1 MTA1 MTA2 MUC1 MUL1 MVP MYBBP1A NABP2 NAP1L1 NCL NCOA1 NCOA2 NCOA3 NDN NEDD8 NFKBIA NFYA NFYB NMT1 NMT2 NPM1 NQO1 NR0B2 NR3C1 NR4A1 OTUD5 PAFAH1B3 PARP1 PATZ1 PBK PCDHA4 PDLIM7 PER2 PHB PIAS1 PIAS2 PIAS4 PIN1 PLAGL1 PLK1 PLK3 PML PNP POLA1 PPA1 PPARGC1A PPM1D PPP1CA PPP1CC PPP1R13L PPP2CA PPP2R2B PPP4C PRIM1 PRKCA PRKD1 PRKDC PRKRA PRKRIR PRMT1 PSMB3 PSMC5 PSMD11 PSME3 PTEN PTGS2 PTK2 PTTG1 RAB4A RAD51 RANBP2 RANBP9 RAP1B RBBP5 RCC1 RCHY1 RFWD2 RNF128 RNF38 RPA1 RPS3 RRM2 RRM2B S100A2 S100A4 S100A6 S100A8 S100B SAT1 SCAMP1 SERPINB9 SET SETD1A SETD7 SETD8 SFN SHISA5 SIN3A SIN3B SIRT1 SMAD2 SMAD3 SMARCA4 SMARCB1 SMARCD1 SMN1 SMYD2 SNRPN SP1 SP3 SQSTM1 SRSF1 SSTR3 STAT6 STK11 STK4 STRA13 STX5 SULT1E1 SUMO1 SYVN1 TADA3 TAF1 TAF1A TAF1B TAF1C TAF9 TAF9B TBP TDG TEC TEP1 TFAP2A TFAP2C TFDP1 THAP8 THRB TK1 TOP1 TOP2A TOP2B TOPORS TP53BP1 TP53BP2 TP53INP1 TP53RK TP63 TP73 TRIAP1 TRIM27 TRIM39 TSC22D1 TSC22D3 TSG101 TTK TXN UBB UBE2A UBE2D1 UBE2I UBE2J1 UBE2K UBE2M UBE2N UBE3A UBE4B UBR5 UFD1L UHRF2 UIMC1 USP10 USP42 USP7 UTP14A VPRBP VRK1 WDR33 WDR5 WDR82 WRN WT1 WWOX XAF1 XRCC6 YBX1 YWHAG YWHAZ YY1 ZBTB2 ZBTB7A ZCCHC10 ZHX1 ZMIZ2 ZNF148 ZNF24 ZNF302 ZNHIT1	96 interactors: ANKRD11 ANKRD12 AR ARID4A ATF3 BCL3 BCOR BRINP1 BRMS1 CBFA2T3 CCND1 CCT5 CEBPD CORO2A CREB3 CREBBP CSNK2A1 CTBP1 DAXX DHX30 EED EP300 EWSR1 GATA1 GATA2 GCM1 GPS2 GTF2I GTF2IRD1 HDAC1 HDAC10 HDAC4 HDAC5 HDAC7 HDAC9 HIF1AN HIST1H4A HNF4A HR HSPA4 HSPA8 IL16 JUN KLF6 LCOR MAPK11 MAPK14 MBD1 NACC1 NCOR1 NCOR2 NFKBIA NR0B2 NR2C1 NR2E3 NRIP1 PARP1 PHB2 PIAS2 PML PPARD PPARG PPP4C PPP4R1 PRKDC RARA RB1 RBBP4 RELA RUNX1 RUNX1T1 RUNX2 RXRA SMYD1 SRC SREBF2 SRY STAT3 SUV39H1 SYK TAB2 TBL1X TBL1XR1 THAP11 THAP7 THRA THRB TMPO TNFRSF14 TP53 TXNIP VHL WISP2 XPO1 YY1 ZBTB16
Entrez ID		7157	8841
HPRD ID		01859	08950
Ensembl ID		ENSG00000141510	ENSG00000171720
Uniprot IDs		H2EHT1 K7PPA8 P04637 Q53GA5	O15379
PDB IDs		1A1U 1AIE 1C26 1DT7 1GZH 1H26 1HS5 1JSP 1KZY 1MA3 1OLG 1OLH 1PES 1PET 1SAE 1SAF 1SAK 1SAL 1TSR 1TUP 1UOL 1XQH 1YC5 1YCQ 1YCR 1YCS 2AC0 2ADY 2AHI 2ATA 2B3G 2BIM 2BIN 2BIO 2BIP 2BIQ 2F1X 2FEJ 2FOJ 2FOO 2GS0 2H1L 2H2D 2H2F 2H4F 2H4H 2H4J 2H59 2J0Z 2J10 2J11 2J1W 2J1X 2J1Y 2J1Z 2J20 2J21 2K8F 2L14 2LY4 2OCJ 2PCX 2VUK 2WGX 2X0U 2X0V 2X0W 2XWR 2YBG 2YDR 2Z5S 2Z5T 3D05 3D06 3D07 3D08 3D09 3D0A 3DAB 3DAC 3IGK 3IGL 3KMD 3KZ8 3LW1 3OQ5 3PDH 3Q01 3Q05 3Q06 3SAK 3TG5 3TS8 3ZME 4AGL 4AGM 4AGN 4AGO 4AGP 4AGQ 4BUZ 4BV2 4HFZ 4HJE 4IBQ 4IBS 4IBT 4IBU 4IBV 4IBW 4IBY 4IBZ 4IJT 4KVP 4LO9 4LOE 4LOF	4A69
Enriched GO Terms of Interacting Partners?		Cellular Response To Stress Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Cellular Response To DNA Damage Stimulus Positive Regulation Of Metabolic Process Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Stress Heterocycle Metabolic Process Positive Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Cellular Protein Modification Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Transcription, DNA-templated Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Cellular Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Response To Stimulus Chromosome Organization Regulation Of Cell Cycle Cellular Macromolecule Biosynthetic Process Cell Cycle Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Cellular Protein Metabolic Process Response To Stimulus RNA Metabolic Process Negative Regulation Of Biosynthetic Process Chromatin Modification Gene Expression Chromatin Organization Apoptotic Process Programmed Cell Death Negative Regulation Of Nucleic Acid-templated Transcription	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Gene Expression RNA Metabolic Process Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Cellular Process Cellular Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Response To Organic Substance Organ Development Chromatin Organization Cellular Response To Organic Substance Cell Differentiation Hemopoiesis DNA-templated Transcription, Initiation Chromosome Organization Developmental Process Immune System Development Cellular Response To Stimulus
Tagcloud ?		anchor anchorage artificial assign bac backcross bacs bands bovine bta19 centromere chrnb1 chromosomes colour construct cryb1 fish gh1 hybrid interspecies library linkage locations loci map meiotic nf1 p4hb unresolved	acetylation acetyltransferases atf2 chip d54mg deacetylase erythematosus favoring gcn5 globally h4 h4ac h4k12 h4k16 h4k5 h4k8 hdac11 imbalance irf1 k12 k16 k8 look lupus monocytes overexpressing pcaf seq sle
Tagcloud (Difference) ?		anchor anchorage artificial assign bac backcross bacs bands bovine bta19 centromere chrnb1 chromosomes colour construct cryb1 fish gh1 hybrid interspecies library linkage locations loci map meiotic nf1 p4hb unresolved	acetylation acetyltransferases atf2 chip d54mg deacetylase erythematosus favoring gcn5 globally h4 h4ac h4k12 h4k16 h4k5 h4k8 hdac11 imbalance irf1 k12 k16 k8 look lupus monocytes overexpressing pcaf seq sle
Tagcloud (Intersection) ?