GPR137B and NLGN4X

		GPR137B	NLGN4X
Description		G protein-coupled receptor 137B	neuroligin 4 X-linked
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Plasma Membrane Membrane	Plasma Membrane Cell Surface Membrane Dendrite Synapse Postsynaptic Membrane Excitatory Synapse Postsynaptic Density Membrane Glutamatergic Synapse GABA-ergic Synapse Symmetric, GABA-ergic, Inhibitory Synapse Neuron To Neuron Synapse Asymmetric, Glutamatergic, Excitatory Synapse Postsynaptic Specialization Membrane
	Molecular Function	Protein Binding	Protein Binding Chloride Ion Binding Neurexin Family Protein Binding Protein Homodimerization Activity Cell Adhesion Molecule Binding Scaffold Protein Binding
	Biological Process	Autophagy Regulation Of Autophagy Regulation Of Macrophage Activation Regulation Of GTPase Activity Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Bone Resorption Positive Regulation Of Protein Localization To Lysosome Positive Regulation Of TORC1 Signaling	Brainstem Development Cell Adhesion Neuron Cell-cell Adhesion Learning Cerebellum Development Neuron Differentiation Adult Behavior Social Behavior Organ Growth Cell-cell Junction Organization Modulation Of Chemical Synaptic Transmission Synapse Organization Regulation Of Synapse Assembly Vocalization Behavior Negative Regulation Of Excitatory Postsynaptic Potential Presynaptic Membrane Assembly Presynapse Assembly
Pathways			Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases			Non-syndromic X-linked mental retardation
GWAS		Diastolic blood pressure ( 27841878) Metabolite levels ( 23823483) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309) Systolic blood pressure ( 27841878) Waist circumference adjusted for body mass index ( 28552196)	Metabolite levels ( 23823483) Schizophrenia ( 25056061 29483656)
Interacting Genes		2 interacting genes: APP TRIM32	2 interacting genes: DLG4 DLGAP2
Entrez ID		7107	57502
HPRD ID		06878	02336
Ensembl ID		ENSG00000077585	ENSG00000146938
Uniprot IDs		O60478	A8K4S1 B3KP11 Q8N0W4
PDB IDs			2WQZ 2XB6 3BE8
Enriched GO Terms of Interacting Partners?		Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Chemokine Production Regulation Of Chemokine Production Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Neuron Differentiation Response To Peptide Response To Cytokine Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Interleukin-17-mediated Signaling Pathway Actin Ubiquitination Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production Regulation Of Nervous System Process Response To Tumor Necrosis Factor Positive Regulation Of Proteolysis Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of Synapse Assembly Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Catabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Neuron Differentiation Endosome To Plasma Membrane Transport Vesicle Adult Behavior Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Learning Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Protein Localization To Phagocytic Vesicle Actin Modification Striated Muscle Myosin Thick Filament Asymmetric, Glutamatergic, Excitatory Synapse Symmetric, GABA-ergic, Inhibitory Synapse Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon
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