PAPSS2

Name	3'-phosphoadenosine 5'-phosphosulfate synthase 2
Structure
Novel Interactors	2 novel interactors: CD83 TLL2
Interactors	4 interactors: APP CEP19 DAPK1 HSF2BP
GO Annotations	Cellular Component	Nucleus Cytosol
	Molecular Function	Nucleotide Binding Catalytic Activity Adenylylsulfate Kinase Activity Sulfate Adenylyltransferase (ATP) Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Nucleotidyltransferase Activity
	Biological Process	Sulfate Assimilation Hormone Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Biosynthetic Process
Pathways	Transport and metabolism of PAPS Metabolism of ingested H2SeO4 and H2SeO3 into H2Se Defective PAPSS2 causes SEMD-PA
Diseases	SEMD, Pakistani type
GWAS	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Heel bone mineral density ( 30598549 ) Leisure-time exercise behaviour ( 19727025 ) Magnesium levels ( 26685716 ) Serum metabolite levels ( 33031748 )
Entrez ID	9060
HPRD ID	04303
Ensembl ID	ENSG00000198682
Uniprot IDs	O95340 Q5TB52
PDB IDs	2AX4 7FH3 7FHA 8I1N 8I1O
GO Terms Enriched among Interactors ?	Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Vesicle Targeting, Trans-Golgi To Periciliary Membrane Compartment Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Regulation Of NMDA Receptor Activity Negative Regulation Of Skeletal Muscle Tissue Growth Vesicle Targeting, To, From Or Within Golgi Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Regulation Of Skeletal Muscle Tissue Growth Negative Regulation Of Interleukin-4 Production Female Meiosis I Peptidase Activator Activity Cellular Response To Manganese Ion Extracellular Matrix Organization Extracellular Structure Organization Heparan Sulfate Binding Signaling Receptor Activator Activity Cellular Response To Hydroperoxide Humoral Immune Response Defense Response To Tumor Cell