DKC1 and TERC

Number of citations of the paper that reports this interaction (PMID 18082603)
43

Data Source:
BioGRID (affinity chromatography technology, unspecified method)

		DKC1	TERC
Gene Name		dyskeratosis congenita 1, dyskerin	telomerase RNA component
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Telomerase Holoenzyme Complex Nucleolus Cytoplasm Cajal Body
	Molecular Function	Telomerase Activity RNA Binding Protein Binding Pseudouridine Synthase Activity Poly(A) RNA Binding
	Biological Process	Telomere Maintenance Pseudouridine Synthesis RRNA Processing RNA Processing Telomere Maintenance Via Telomerase Cell Proliferation
Pathways		Telomere Maintenance Chromosome Maintenance Extension of Telomeres Telomere Extension By Telomerase
Drugs
Diseases
GWAS			Telomere length ( 23535734 21573004 20139977 23001564)
Protein-Protein Interactions		10 interactors: CSNK2A1 EEF1G EIF3F ERG LYPLA2 MAPK6 RUVBL1 SHQ1 SSR1 TERC	1 interactors: DKC1
Entrez ID		1736	7012
HPRD ID		02129
Ensembl ID		ENSG00000130826	ENSG00000270141
Uniprot IDs		O60832
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Protein Metabolic Process Negative Regulation Of Potassium Ion Export Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of RRNA Processing Regulation Of Heart Rate By Hormone Protein Metabolic Process Cellular Macromolecular Complex Assembly Negative Regulation Of Ribosome Biogenesis Translation Ribonucleoprotein Complex Assembly	Telomere Maintenance Via Telomerase RNA-dependent DNA Replication Telomere Maintenance Via Telomere Lengthening Pseudouridine Synthesis Telomere Maintenance DNA Biosynthetic Process RRNA Processing RRNA Metabolic Process RNA Modification Ribosome Biogenesis DNA Replication Ribonucleoprotein Complex Biogenesis
Tagcloud ?		aneuploidy aplastic attrition circumstances complexly congenita constitutional cryptic delineated destabilize dyskeratosis enforcing etiologic helpful mucocutaneous multiorgan oncogenesis prominent recessive regenerative revision shelterin shorten stereotypical subtle telomere telomeropathy terc tert	anticancer catalytic cloned compensate division elucidated encoding erosion fusions generally homolog immortality length neoplasms p80 protection repeat repeats repressed ribonucleoprotein telomerase telomere telomeric tep1 terf1 terf2 tert upregulated withdrawal
Tagcloud (Difference) ?		aneuploidy aplastic attrition circumstances complexly congenita constitutional cryptic delineated destabilize dyskeratosis enforcing etiologic helpful mucocutaneous multiorgan oncogenesis prominent recessive regenerative revision shelterin shorten stereotypical subtle telomeropathy	anticancer catalytic cloned compensate division elucidated encoding erosion fusions generally homolog immortality length neoplasms p80 protection repeat repeats repressed ribonucleoprotein telomerase telomeric tep1 terf1 terf2 upregulated withdrawal
Tagcloud (Intersection) ?		telomere terc tert