FGFR1OP

Gene Name		FGFR1 oncogene partner
Image
Gene Ontology Annotations	Cellular Component	Nucleus Centrosome Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Tyrosine Kinase Activity Protein Binding Protein Kinase Binding Protein Tyrosine Kinase Inhibitor Activity Protein Homodimerization Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Negative Regulation Of Protein Kinase Activity Organelle Organization Positive Regulation Of Cell Proliferation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Microtubule Anchoring Negative Regulation Of Protein Tyrosine Kinase Activity
Pathways		Organelle biogenesis and maintenance Signaling by FGFR in disease Assembly of the primary cilium G2/M Transition Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Signaling by FGFR1 mutants Loss of Nlp from mitotic centrosomes Signaling by FGFR mutants Centrosome maturation Signaling by FGFR1 fusion mutants Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes
Drugs
Diseases
GWAS		Graves' disease ( 21841780) Vitiligo ( 20526339)
Protein-protein Interactions		4 interactors: CEP19 NAGK PPP2R1B VASP
Entrez ID		11116
HPRD ID		10392
Ensembl ID
Uniprot IDs		B4DH64 O95684
PDB IDs		2D68
Enriched GO Terms of Interacting Partners?		N-acetylmannosamine Metabolic Process N-acetylneuraminate Catabolic Process N-acetylneuraminate Metabolic Process
Tagcloud ?		aberrant abl1 balanced bcr chimaeric cloning cmml constitutive constitutively cytological fusion hematopoietic lineage mimic monocytic myelomonocytic myeloproliferative neoplasms q11 q27 remissions ret seem skew sorafenib tk transform translocations v617f