TBX3 and UFSP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TBX3	UFSP1
Description		T-box transcription factor 3	UFM1 specific peptidase 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cilium	Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeUFMylase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Blood Vessel Development In Utero Embryonic Development Cell Fate Specification Heart Looping Heart Morphogenesis Outflow Tract Morphogenesis Atrioventricular Bundle Cell Differentiation Endocardial Cushion Formation DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Anterior/posterior Axis Specification, Embryo Animal Organ Morphogenesis Specification Of Animal Organ Position Stem Cell Population Maintenance Limbic System Development Male Genitalia Development Female Genitalia Development Negative Regulation Of Epithelial Cell Differentiation Mammary Gland Development Regulation Of Protein Stability Luteinizing Hormone Secretion Embryonic Heart Tube Development Limb Morphogenesis Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Forelimb Morphogenesis Atrioventricular Canal Development Regulation Of Cell Population Proliferation Inner Ear Morphogenesis Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Myoblast Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Follicle-stimulating Hormone Secretion Mesoderm Morphogenesis Semicircular Canal Morphogenesis Smooth Muscle Cell Differentiation Cardiac Muscle Cell Differentiation Roof Of Mouth Development Cardiac Epithelial To Mesenchymal Transition Ventricular Septum Morphogenesis Branching Involved In Mammary Gland Duct Morphogenesis Mammary Placode Formation Cardiac Muscle Cell Fate Commitment Sinoatrial Node Cell Development Hepatoblast Differentiation Regulation Of Protein Complex Stability Stem Cell Proliferation Ureteric Peristalsis Cellular Senescence Cardiac Jelly Development Atrioventricular Canal Morphogenesis Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Stem Cell Differentiation	Proteolysis Protein Maturation Protein Ufmylation
Pathways		Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Diseases		Ulnar-mammary syndrome; Schinzel syndrome
GWAS		Appendicular lean mass ( 33097823) Atrial fibrillation ( 29892015) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Blood pressure ( 21572416 21909110) Bone mineral density (lumbar spine) in inflammatory bowel disease ( 29603369) Breast cancer ( 29059683) Childhood asthma exacerbations in long-acting beta2-agonist treatment ( 33706416) Colorectal cancer ( 23266556) Colorectal cancer or advanced adenoma ( 30510241) Diastolic blood pressure ( 27618452 27841878 26390057 28135244 29403010 19430479) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Facial morphology ( 31763980) FEV1 ( 30804560) Global electrical heterogeneity phenotypes ( 29622589) Heel bone mineral density ( 30598549 28869591) Hematological and biochemical traits ( 31902109) Hypertension ( 30487518) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) Idiopathic dilated cardiomyopathy ( 29495422) Left ventricular QRS voltage ( 27195777) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Longevity ( 30294719) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 28166213 30804560 26635082) Mean arterial pressure ( 29403010 30487518) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Metabolite levels ( 23823483) Methadone dose in opioid dependence ( 28115739) Night sleep phenotypes ( 27126917) Nose morphology ( 29921221) Percent mammographic density ( 22532574) PR interval ( 20062060 30679814 32439900 25035420 30046033) PR segment duration ( 24850809) Prostate-specific antigen levels ( 28139693) QRS complex (12-leadsum) ( 27659466) QRS duration ( 27577874 30679814) Serum prostate-specific antigen levels ( 21160077) Systolic blood pressure ( 25249183 29403010 27618452 27841878) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Urate levels in overweight individuals ( 25811787)	Bipolar disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Nonunion in individuals with fractures ( 30680360) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020) Resting heart rate ( 20639392 27798624 29769521)
Interacting Genes		14 interacting genes: CA8 CSF3 PFDN5 PLEKHF2 PRR20A PRR20B PRR20C PRR20D PRR20E SIRPA TLE5 TOLLIP UFSP1 ZNF34	43 interacting genes: C10orf55 CIDEB CIDEC COG6 CREB5 CSTF2 FAM222B FANCL FOXH1 FOXI1 GLYCTK GPSM3 HNF1B HOXC9 HSF4 INCA1 KRTAP15-1 LASP1 MSRB3 MYOZ3 PITX1 PITX2 POGZ POU6F2 PROP1 PRR22 RAPGEF3 RBM14 RBPMS2 RUSC1 SMARCC1 SNRPC SPG21 TBX3 TCF7L2 TLX3 UBQLN2 VAC14 VAX2 VGLL3 VPS37C WWOX ZIC1
Entrez ID		6926	402682
HPRD ID		03373	18630
Ensembl ID		ENSG00000135111	ENSG00000176125
Uniprot IDs		O15119	A0AAR1ZLH9 Q6NVU6
PDB IDs		1H6F
Enriched GO Terms of Interacting Partners?			DNA-binding Transcription Factor Activity Chromatin Embryonic Morphogenesis DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Animal Organ Morphogenesis Pattern Specification Process Hepatoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Morphogenesis Embryonic Digestive Tract Morphogenesis Embryonic Organ Morphogenesis Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Myoblast Fate Commitment DNA Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process System Development Transcription Regulator Complex Central Nervous System Development Somatotropin Secreting Cell Differentiation Regulation Of Primary Metabolic Process Embryonic Hindlimb Morphogenesis Regionalization Gland Development Pituitary Gland Development Lipid Droplet Fusion Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Hindlimb Morphogenesis Nucleus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Transcription Cis-regulatory Region Binding Inner Ear Morphogenesis Outflow Tract Morphogenesis Lipid Transfer Activity Regulation Of Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Gene Expression Negative Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Sequence-specific DNA Binding Axis Specification
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