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TBXT and RPS6KA2
TBXT
RPS6KA2
Description
T-box transcription factor T
ribosomal protein S6 kinase A2
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Nucleus
Nucleoplasm
Cytoplasm
Spindle
Cytosol
Synapse
Meiotic Spindle
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Transcription Corepressor Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Sequence-specific Double-stranded DNA Binding
Nucleotide Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Ribosomal Protein S6 Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Metal Ion Binding
Protein Serine Kinase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Mesoderm Formation
Cell Fate Specification
Somitogenesis
Heart Morphogenesis
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Signal Transduction
Mesoderm Development
Anterior/posterior Axis Specification, Embryo
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Cardiac Muscle Cell Myoblast Differentiation
Primitive Streak Formation
Oocyte Maturation
Brain Renin-angiotensin System
Signal Transduction
Chemical Synaptic Transmission
Heart Development
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Cardiac Muscle Cell Apoptotic Process
Intracellular Signal Transduction
TORC1 Signaling
Positive Regulation Of Apoptotic Process
Negative Regulation Of Cell Cycle
Negative Regulation Of Meiotic Nuclear Division
Heart Contraction
Regulation Of Protein Processing
Cellular Response To Carbohydrate Stimulus
Pathways
Cardiogenesis
Germ layer formation at gastrulation
Epithelial-Mesenchymal Transition (EMT) during gastrulation
Formation of paraxial mesoderm
Formation of axial mesoderm
Formation of definitive endoderm
ERK/MAPK targets
CREB phosphorylation
Senescence-Associated Secretory Phenotype (SASP)
Senescence-Associated Secretory Phenotype (SASP)
Recycling pathway of L1
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
RSK activation
RSK activation
Gastrin-CREB signalling pathway via PKC and MAPK
Drugs
Diseases
GWAS
3-month functional outcome in ischaemic stroke (modified Rankin score) (
30796134
)
Alzheimer's disease progression score (
29860282
)
Bipolar disorder (
31043756
34002096
)
Bipolar I disorder (
31043756
)
Blood pressure (smoking interaction) (
25189868
)
Café-au-lait macule number in neurofibromatosis type1 (
32869517
)
Dental caries (
23259602
)
HDL cholesterol levels in HIV infection (
33109212
)
Inflammatory bowel disease (
23128233
27569725
)
Macrovascular complications in type 2 diabetes (
33430853
)
Pre-treatment viral load in HIV-1 infection (
31219150
)
Smooth-surface caries (
24556642
)
Urinary metabolite levels in chronic kidney disease (
31959995
)
Waist circumference (
28552196
)
Interacting Genes
3 interacting genes:
NFIA
NFIB
NFIC
12 interacting genes:
BAD
CREB1
FLNC
FOS
JUN
L1CAM
MAGI1
MAP2K1
MAPK1
MAPK3
SHANK1
TP53
Entrez ID
6862
6196
HPRD ID
03236
03403
Ensembl ID
ENSG00000164458
ENSG00000071242
Uniprot IDs
J3KP65
O15178
B7Z3B5
F2Z2J1
Q15349
X5D337
PDB IDs
5QRF
5QRG
5QRH
5QRI
5QRJ
5QRK
5QRL
5QRM
5QRN
5QRO
5QRP
5QRQ
5QRR
5QRS
5QRT
5QRU
5QRV
5QRW
5QRX
5QRY
5QRZ
5QS0
5QS1
5QS2
5QS3
5QS4
5QS5
5QS6
5QS7
5QS8
5QS9
5QSA
5QSB
5QSC
5QSD
5QSE
5QSF
5QSG
5QSH
5QSI
5QSJ
5QSK
5QSL
5QT0
6F58
6F59
6ZU8
7HI8
7HI9
7ZK2
7ZKF
7ZL2
8A10
8A7N
8CDN
8FMU
Enriched GO Terms of Interacting Partners
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Glial Cell Fate Specification
DNA Replication
Exit From Mitosis
Generation Of Neurons
Neuron Fate Specification
Glial Cell Proliferation
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Retina Development In Camera-type Eye
Cell Fate Specification
DNA-binding Transcription Factor Activity
Neural Precursor Cell Proliferation
Negative Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis
Lung Ciliated Cell Differentiation
Neurogenesis
DNA Metabolic Process
Double-stranded DNA Binding
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Positive Regulation Of Macromolecule Biosynthetic Process
Cell Differentiation Involved In Salivary Gland Development
Fibrillar Center
Negative Regulation Of Mesenchymal Cell Proliferation Involved In Lung Development
Brain Renin-angiotensin System
Positive Regulation Of Biosynthetic Process
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Principal Sensory Nucleus Of Trigeminal Nerve Development
Developmental Maturation
Chromatin
Response To Wounding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Club Cell Differentiation
Positive Regulation Of Macromolecule Metabolic Process
Salivary Gland Cavitation
Anterior Commissure Morphogenesis
Ribosomal Protein S6 Kinase Activity
Regulation Of Blood Volume By Renin-angiotensin
Positive Regulation Of Transcription By RNA Polymerase II
Ureter Development
Positive Regulation Of Metabolic Process
Gene Expression
Multi-ciliated Epithelial Cell Differentiation
Type II Pneumocyte Differentiation
Cerebellar Mossy Fiber
Negative Regulation Of Mesenchymal Cell Proliferation
Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure
Animal Organ Development
Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis
Type I Pneumocyte Differentiation
Negative Regulation Of Meiotic Nuclear Division
Macromolecule Biosynthetic Process
Regulation Of Golgi Inheritance
Trachea Formation
ERBB3 Signaling Pathway
ERBB2-ERBB3 Signaling Pathway
Bergmann Glial Cell Differentiation
Regulation Of Golgi Organization
Regulation Of Early Endosome To Late Endosome Transport
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Face Development
Schwann Cell Development
Animal Organ Formation
ERBB2 Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Interleukin-34-mediated Signaling Pathway
Hematopoietic Or Lymphoid Organ Development
Lung Morphogenesis
Transforming Growth Factor Beta Receptor Signaling Pathway
Thyroid Gland Development
Astrocyte Differentiation
Insulin-like Growth Factor Receptor Signaling Pathway
Cellular Developmental Process
Regulation Of Stress-activated MAPK Cascade
Cell Differentiation
Gland Development
Anatomical Structure Morphogenesis
Regulation Of Stress-activated Protein Kinase Signaling Cascade
Regulation Of Multicellular Organismal Process
Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
Caveolin-mediated Endocytosis
Positive Regulation Of Macrophage Proliferation
Positive Regulation Of Cellular Component Organization
Response To Lipid
Cell Surface Receptor Signaling Pathway
Response To Nicotine
Transcription Factor AP-1 Complex
Regulation Of Cell Development
Thymus Development
Intracellular Signaling Cassette
Cardiac Neural Crest Cell Development Involved In Heart Development
Response To Epidermal Growth Factor
ERK1 And ERK2 Cascade
Positive Regulation Of MiRNA Transcription
Outer Ear Morphogenesis
Identical Protein Binding
Cellular Response To Starvation
Positive Regulation Of MiRNA Metabolic Process
Glial Cell Development
Response To Mechanical Stimulus
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Tagcloud (Intersection)
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