SULT1A3 and SHMT1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SULT1A3	SHMT1
Gene Name		sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3	serine hydroxymethyltransferase 1 (soluble)
Image
Gene Ontology Annotations	Cellular Component	Cytosol	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Extracellular Vesicular Exosome
	Molecular Function	Aryl Sulfotransferase Activity Sulfotransferase Activity	Glycine Hydroxymethyltransferase Activity L-allo-threonine Aldolase Activity Amino Acid Binding Pyridoxal Phosphate Binding Protein Homodimerization Activity
	Biological Process	Catecholamine Metabolic Process Xenobiotic Metabolic Process Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Steroid Metabolic Process Flavonoid Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Cellular Protein Metabolic Process Small Molecule Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Sulfation	L-serine Catabolic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Purine Nucleobase Biosynthetic Process Glycine Biosynthetic Process From Serine Cellular Nitrogen Compound Metabolic Process Tetrahydrofolate Interconversion Small Molecule Metabolic Process Carnitine Biosynthetic Process Folic Acid Metabolic Process Protein Tetramerization Protein Homotetramerization
Pathways			Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Metabolism of amino acids and derivatives Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Carnitine synthesis Metabolism of folate and pterines Defective TCN2 causes hereditary megaloblastic anemia Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism
Drugs			Pyridoxal Phosphate Tetrahydrofolic acid Glycine Mimosine Triglu-5-Formyl-Tetrahydrofolate 5-Hydroxymethylene-6-Hydrofolic Acid N-Pyridoxyl-Glycine-5-Monophosphate
Diseases
GWAS
Protein-Protein Interactions		6 interactors: APP KHDRBS2 NIF3L1 SHMT1 SMN1 TK1	7 interactors: CSNK2B DEDD DLEU1 MAPK9 PIM1 PRSS23 SULT1A3
Entrez ID		6818	6470
HPRD ID		07199	01643
Ensembl ID		ENSG00000261052	ENSG00000176974
Uniprot IDs		P50224 Q1ET61	B4DPM9 P34896
PDB IDs		1CJM 2A3R	1BJ4
Enriched GO Terms of Interacting Partners?		Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Pteridine-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Protein Homotetramerization Nitrogen Compound Metabolic Process Fetal Process Involved In Parturition Protein Tetramerization 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Skeletal Muscle Cell Proliferation Synaptic Growth At Neuromuscular Junction Cellular Component Assembly Collateral Sprouting In Absence Of Injury Dihydrobiopterin Metabolic Process L-serine Catabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Carnitine Biosynthetic Process Nucleobase-containing Compound Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Response To Cortisol Thymidine Metabolic Process Axon Choice Point Recognition Protein Homooligomerization Deoxyribonucleoside Monophosphate Biosynthetic Process Glycine Biosynthetic Process From Serine Neuron Remodeling Tetrahydrofolate Interconversion Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage Cofactor Metabolic Process Folic Acid Metabolic Process Glycine Biosynthetic Process Purine Nucleobase Biosynthetic Process Serine Family Amino Acid Catabolic Process Carnitine Metabolic Process MRNA Processing Parturition Cellular Copper Ion Homeostasis Protein Oligomerization Amino-acid Betaine Metabolic Process Copper Ion Homeostasis Suckling Behavior Tetrahydrofolate Metabolic Process Response To Copper Ion Cellular Metabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle L-serine Metabolic Process MRNA Metabolic Process Neuron Maturation	Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Kinase Activity Negative Regulation Of Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter JUN Phosphorylation Apoptotic Process Regulation Of Catalytic Activity Programmed Cell Death Positive Regulation Of Prostaglandin Biosynthetic Process Cell Death Death Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Activin Receptor Signaling Pathway Adiponectin-activated Signaling Pathway Phosphate-containing Compound Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Endothelial Tube Morphogenesis Protein Phosphorylation Apoptotic Signaling Pathway Protein Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Prostaglandin Secretion Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Regulation Of Apoptotic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Positive Regulation Of Catalytic Activity Regulation Of Transcription From RNA Polymerase I Promoter Regulation Of Cell Death Positive Regulation Of Icosanoid Secretion Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Metabolic Process Sulfation Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Kinase Activity Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Kinase Activity Positive Regulation Of Fatty Acid Transport Flavonoid Metabolic Process Decidualization Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Tagcloud ?		1a2 1e1 absent adjacent canc cyp1a1 cyp1a2 d1 decreases estrogen hydroxylation ihc limit melatonin mt1 ncanc oncostatic pilot positively positivity representative specimens stimulates sulfonation suppresses	aa aas african american ancestry asian associations carbon circle comparisons copyright correcting ea eas eleven european folate metabolizing modest mtr mtrr participated polygenetic polymorphisms reserved rights slc19a1 snps tyms
Tagcloud (Difference) ?		1a2 1e1 absent adjacent canc cyp1a1 cyp1a2 d1 decreases estrogen hydroxylation ihc limit melatonin mt1 ncanc oncostatic pilot positively positivity representative specimens stimulates sulfonation suppresses	aa aas african american ancestry asian associations carbon circle comparisons copyright correcting ea eas eleven european folate metabolizing modest mtr mtrr participated polygenetic polymorphisms reserved rights slc19a1 snps tyms
Tagcloud (Intersection) ?