UAP1 and RGS4

		UAP1	RGS4
Description		UDP-N-acetylglucosamine pyrophosphorylase 1	regulator of G protein signaling 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Nucleus Cytoplasm Plasma Membrane Protein-containing Complex
	Molecular Function	UDP-N-acetylglucosamine Diphosphorylase Activity Transferase Activity Transferase Activity, Transferring Phosphorus-containing Groups Nucleotidyltransferase Activity Identical Protein Binding UDP-N-acetylgalactosamine Diphosphorylase Activity Uridylyltransferase Activity Protein Serine Pyrophosphorylase Activity	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Calmodulin Binding Protein Kinase Binding
	Biological Process	Immune System Process UDP-N-acetylglucosamine Biosynthetic Process Positive Regulation Of Type I Interferon Production Innate Immune Response Antiviral Innate Immune Response	Response To Amphetamine G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Heart Rate Response To Cocaine Response To Ethanol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion Transport Negative Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Actin Filament Organization Negative Regulation Of Glycine Import Across Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Dorsal Root Ganglion Development Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Synthesis of UDP-N-acetyl-glucosamine	G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events
Drugs		Uridine-Diphosphate-N-Acetylgalactosamine Uridine-Diphosphate-N-Acetylglucosamine
Diseases
GWAS			Daytime nap ( 33568662) Response to fenofibrate (triglyceride levels) ( 27002377) Response to mTOR inhibitor (rapamycin) ( 24009623)
Interacting Genes		1 interacting genes: FBXL17	15 interacting genes: CALM1 COPB1 COPB2 EGFR ERBB3 GABBR1 GNAI1 GNAI2 GNAO1 GNAQ KCMF1 KRIT1 PLCB1 PTAFR UBR1
Entrez ID		6675	5999
HPRD ID		04178	03947
Ensembl ID		ENSG00000117143	ENSG00000117152
Uniprot IDs		A0A140VKC0 Q16222	P49798
PDB IDs		1JV1 1JV3 1JVD 1JVG 6Z2F 8QH2
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Glycine Import Across Plasma Membrane Negative Regulation Of Dopamine Receptor Signaling Pathway Dorsal Root Ganglion Development Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Negative Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Amino Acid Transport Response To Cocaine Positive Regulation Of Excitatory Postsynaptic Potential Tissue Development Ganglion Development G-protein Alpha-subunit Binding Negative Regulation Of Muscle Hypertrophy Response To Amphetamine Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transport Negative Regulation Of Organ Growth Positive Regulation Of Heart Contraction Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Heart Rate Negative Regulation Of Cardiac Muscle Tissue Growth Response To Amine Negative Regulation Of Cardiac Muscle Hypertrophy Decidualization Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Transcription By RNA Polymerase I Negative Regulation Of Transcription By RNA Polymerase I Neural Crest Cell Differentiation Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Modulation Of Excitatory Postsynaptic Potential Negative Regulation Of G Protein-coupled Receptor Signaling Pathway	Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Secretion G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Positive Regulation Of Mitotic Cell Cycle Phase Transition Adenylate Cyclase Regulator Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Transport Plasma Membrane Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Acetylcholine Receptor Signaling Pathway Inositol Trisphosphate Metabolic Process Postsynaptic Signal Transduction Negative Regulation Of Secretion By Cell Regulation Of G1/S Transition Of Mitotic Cell Cycle Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Regulation Of Cell Cycle G1/S Phase Transition Cell Surface Receptor Signaling Pathway COPI Vesicle Coat Receptor Complex Regulation Of Secretion Regulation Of Peptide Hormone Secretion G Protein-coupled Receptor Binding G Protein Activity Membrane COPI-coated Vesicle Membrane Protein Tyrosine Kinase Activator Activity Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of Cell Cycle Process GABA-ergic Synapse Positive Regulation Of Cell Cycle Process Regulation Of Hormone Secretion Purinergic Nucleotide Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission ERBB2 Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Response To Prostaglandin E Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Inositol Phosphate Metabolic Process Membrane Coat Protein Tyrosine Kinase Activity
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