RNMT and RNGTT

Number of citations: 0 (PubMedID 9705270)
Data Source: BioGRID (pull down), HPRD (in vitro)

		RNMT	RNGTT
Name		RNA guanine-7 methyltransferase	RNA guanylyltransferase and 5'-phosphatase
Structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm MRNA Capping Enzyme Complex Receptor Complex MRNA Cap Methyltransferase RNMT:RAMAC Complex	Nucleus Nucleoplasm
	Molecular Function	RNA Binding MRNA 5'-cap (guanine-N7-)-methyltransferase Activity Protein Binding Methyltransferase Activity Transferase Activity	Nucleotide Binding Catalytic Activity MRNA Guanylyltransferase Activity Polynucleotide 5'-phosphatase Activity Phosphoprotein Phosphatase Activity Protein Binding ATP Binding GTP Binding RNA Guanylyltransferase Activity Transferase Activity Nucleotidyltransferase Activity Hydrolase Activity Inorganic Triphosphate Phosphatase Activity MRNA 5'-triphosphate Monophosphatase Activity
	Biological Process	7-methylguanosine MRNA Capping MRNA Processing Methylation RNA 5'-cap (guanine-N7)-methylation Cellular Response To Leukemia Inhibitory Factor	Nucleobase-containing Compound Metabolic Process 7-methylguanosine MRNA Capping RNA Processing MRNA Processing
Pathways		RNA Pol II CTD phosphorylation and interaction with CE during HIV infection mRNA Capping RNA Pol II CTD phosphorylation and interaction with CE	RNA Pol II CTD phosphorylation and interaction with CE during HIV infection mRNA Capping RNA Pol II CTD phosphorylation and interaction with CE
GWAS		Fractures ( 30158200 )	Colorectal or endometrial cancer ( 26621817 ) Depression in smokers ( 30219690 ) Graft survival time in renal transplantation (donor effect) ( 32080893 ) Height ( 31562340 ) Response to statin therapy ( 20339536 ) Simvastatin-induced myopathy ( 31220337 ) Subcutaneous adipose tissue ( 22589738 )
Novel Interactors		None recorded	1 novel interactors: AP3B1
Interacting Genes		5 interacting genes: EIF4E GMCL1 KPNA2 PLEKHA3 RNGTT	4 interacting genes: APPBP2 CEBPA CRYAA RNMT
Entrez ID		8731	8732
HPRD ID		04622	04621
Ensembl ID		ENSG00000101654	ENSG00000111880
Uniprot IDs		A8K946 K7EP06 O43148	B4DSJ8 O60942
PDB IDs		3BGV 3EPP 5E8J 5E9J 5E9W 8Q69 8Q8G 8Q9W	2C46 3S24 8P4A 8P4B 8P4C 8P4D 8P4E 8W8E 8W8F
GO Terms Enriched among Interactors		Eukaryotic Initiation Factor 4G Binding MRNA Guanylyltransferase Activity MRNA 5'-triphosphate Monophosphatase Activity Inorganic Triphosphate Phosphatase Activity RNA Guanylyltransferase Activity Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Polynucleotide 5'-phosphatase Activity MRNA Cap Binding Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Translation At Postsynapse Viral Penetration Into Host Nucleus Nuclear Transport Nucleocytoplasmic Transport Intracellular Transport Of Virus 7-methylguanosine MRNA Capping Host Cell Intracellular Transport NLS-dependent Protein Nuclear Import Complex RNA Cap Binding RNA 7-methylguanosine Cap Binding Chromatoid Body Eukaryotic Translation Initiation Factor 4F Complex	Granulocyte Differentiation Mitochondrion Organization Lung Development RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Establishment Of Protein Localization To Mitochondrial Membrane Involved In Mitochondrial Fission MRNA Capping Enzyme Complex MRNA 5'-cap (guanine-N7-)-methyltransferase Activity MRNA Cap Methyltransferase RNMT:RAMAC Complex RNA 5'-cap (guanine-N7)-methylation Myeloid Leukocyte Differentiation CHOP-C/EBP Complex Response To Phenylpropanoid White Fat Cell Proliferation Myeloid Cell Differentiation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Lens Fiber Cell Morphogenesis Cell Morphogenesis Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Positive Regulation Of NK T Cell Differentiation Regulation Of NK T Cell Differentiation 7-methylguanosine MRNA Capping RNA (guanine-N7)-methylation Fat Cell Proliferation Microvesicle Leukocyte Differentiation Response To Lithium Ion Transcription By RNA Polymerase I Urea Metabolic Process Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion HMG Box Domain Binding RNA Metabolic Process Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Urea Cycle Interleukin-6-mediated Signaling Pathway Animal Organ Development Positive Regulation Of Cell Activation STAT Family Protein Binding Osteoblast Development Tubulin Complex Assembly Response To UV-A Embryonic Camera-type Eye Morphogenesis Lens Morphogenesis In Camera-type Eye Anterograde Synaptic Vesicle Transport AP-3 Adaptor Complex