SMARCA1 and BAZ1B

Number of citations: 53 (PubMedID 11980720)
Data Source: HPRD (in vitro, in vivo)

		SMARCA1	BAZ1B
Name		SNF2 related chromatin remodeling ATPase 1	bromodomain adjacent to zinc finger domain 1B
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome NURF Complex CERF Complex ATPase Complex	Chromatin Condensed Chromosome Nucleus Nucleoplasm Pericentric Heterochromatin Nucleolus Nuclear Replication Fork WICH Complex B-WICH Complex
	Molecular Function	DNA Binding Chromatin Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity Nucleosome Binding ATP-dependent DNA/DNA Annealing Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding ATP-dependent Chromatin Remodeler Activity Nucleosome Array Spacer Activity	Nucleotide Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Histone Kinase Activity Histone Binding Metal Ion Binding Histone H2AXY142 Kinase Activity
	Biological Process	Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Brain Development Neuron Differentiation Heterochromatin Formation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II DNA Damage Response Post-translational Protein Modification Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Negative Regulation Of Mitotic Chromosome Condensation
Pathways		None	B-WICH complex positively regulates rRNA expression Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
GWAS		Pulse pressure ( 27841878 ) Schizophrenia x sex interaction ( 34099189 ) Systolic blood pressure ( 27841878 )	C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809 ) Hip index ( 34021172 ) Hypertriglyceridemia ( 23505323 ) Hyperuricemia ( 29124443 ) Lamb consumption ( 32066663 ) Lipoprotein (a) levels ( 33730874 ) Malaria ( 31844061 ) Meat-related diet ( 32066663 ) Metabolic syndrome ( 31589552 ) Migraine ( 27182965 ) Non-oily fish consumption ( 32066663 ) Platelet count ( 32888494 ) Protein C levels ( 20802025 ) Pursuit maintenance gain ( 29064472 ) Serum alkaline phosphatase levels ( 33339817 ) Serum uric acid levels ( 30993211 ) Triglyceride levels ( 32203549 ) Triglyceride levels x fish oil supplementation interaction (2df) ( 33760818 ) Triglycerides ( 20864672 ) Urate levels ( 31985003 23263486 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500 ) Waist-to-hip ratio adjusted for body mass index ( 28448500 )
Interacting Genes		2 interacting genes: BAZ1B H3-3A	16 interacting genes: CDT1 H2AX KANSL1 KAT8 MAILR MTNR1A MYO1C NR4A2 PCNA RNF10 SIRT1 SMARCA1 SMARCA5 SMARCC2 SMARCE1 SUMO2
Entrez ID		6594	9031
HPRD ID		02055	10416
Ensembl ID		ENSG00000102038	ENSG00000009954
Uniprot IDs		A0A0A0MRP6 B7ZLQ5 P28370	Q9UIG0
PDB IDs		Not available	1F62 5NNF
GO Terms Enriched among Interactors		Negative Regulation Of Chromosome Condensation Regulation Of Chromosome Condensation Negative Regulation Of Chromosome Organization Regulation Of Chromosome Organization WICH Complex Negative Regulation Of Mitotic Chromosome Condensation Histone H2AXY142 Kinase Activity Regulation Of Centromere Complex Assembly Pericentric Heterochromatin Formation Histone Kinase Activity Barr Body B-WICH Complex Subtelomeric Heterochromatin Formation Chromatin Remodeling Negative Regulation Of Cellular Component Organization Positive Regulation Of Transcription By RNA Polymerase III Inner Kinetochore Nuclear Replication Fork RNA Polymerase II Core Promoter Sequence-specific DNA Binding Chromatin Organization Oocyte Maturation Regulation Of Transcription By RNA Polymerase III Positive Regulation Of Transcription By RNA Polymerase I Pericentric Heterochromatin Chromatin Condensed Chromosome Nucleosomal DNA Binding Regulation Of Organelle Organization Regulation Of Transcription By RNA Polymerase I Non-membrane Spanning Protein Tyrosine Kinase Activity Oogenesis Embryo Implantation Constitutive Heterochromatin Formation Female Gamete Generation Structural Constituent Of Chromatin Nucleus Organization Single Fertilization Spermatid Development Male Gonad Development Nucleosome Assembly Muscle Cell Differentiation Multicellular Organism Growth	Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Remodeling Positive Regulation Of RNA Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of DNA Repair Heterochromatin Formation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Kinetochore Negative Regulation Of Gene Expression, Epigenetic Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Nucleoplasm Regulation Of Primary Metabolic Process Positive Regulation Of Double-strand Break Repair Chromatin Regulation Of DNA Repair Regulation Of RNA Metabolic Process Epigenetic Regulation Of Gene Expression CERF Complex Nucleosome Organization Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA Replication Nucleosome Array Spacer Activity Regulation Of Double-strand Break Repair Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Histone Binding NURF Complex RDNA Heterochromatin Formation Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Chromosome B-WICH Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Metabolic Process BBAF Complex Regulation Of Mitochondrial Transcription Negative Regulation Of Macromolecule Biosynthetic Process Chromatin Silencing Complex