BOLA2B and RAB4B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BOLA2B	RAB4B
Description		bolA family member 2B	RAB4B, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Iron-sulfur Cluster Assembly Complex	Endosome Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Secretory Granule Membrane Early Endosome Membrane Insulin-responsive Compartment Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Protein Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Intracellular Iron Ion Homeostasis Iron-sulfur Cluster Assembly [2Fe-2S] Cluster Assembly Cell Redox Homeostasis Protein Maturation	Protein Transport Vesicle-mediated Transport Regulation Of Endocytosis Rab Protein Signal Transduction Endosomal Vesicle Fusion Early Endosome To Golgi Transport D-glucose Import
Pathways		Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Neutrophil degranulation RAB geranylgeranylation MET receptor recycling
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)	Carotid intima media thickness (mean) ( 31801372) Chronic obstructive pulmonary disease ( 22080838 28166215) Emphysema imaging phenotypes ( 26030696) Eosinophil percentage of white cells ( 32888494) Hematocrit ( 32888494) Hemoglobin ( 32888494) Kawasaki disease ( 22081228) Red blood cell count ( 32888494) Smoking behaviour (cigarettes smoked per day) ( 30617275)
Interacting Genes		32 interacting genes: ADAMTSL4 ANKRD55 BIRC2 BIRC7 C10orf55 C1orf94 CCDC138 CGGBP1 GLRX3 HDX ID3 IHO1 IL16 MBD3L1 MEOX2 MOBP NTAQ1 RAB4B RGS17 SLITRK5 TK1 TXNRD3 XIAP ZFP90 ZNF177 ZNF511 ZNF559-ZNF177 ZNF581 ZNF620 ZNF688 ZNF76 ZNF774	9 interacting genes: BOLA2 BOLA2B CDC45 EXOC5 GARIN6 RAB7A RABAC1 RABEP1 VPS52
Entrez ID		654483	53916
HPRD ID		19050	11473
Ensembl ID		ENSG00000169627	ENSG00000167578
Uniprot IDs		A0A499FJE1 Q9H3K6	P61018
PDB IDs			2O52
Enriched GO Terms of Interacting Partners?		Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Zinc Ion Binding Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of RNA Metabolic Process Positive Regulation Of Protein Polyubiquitination Protein Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Polyubiquitination Positive Regulation Of Post-translational Protein Modification Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Metal Ion Binding Regulation Of Gene Expression Positive Regulation Of Protein Ubiquitination Cysteine-type Endopeptidase Inhibitor Activity Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Leptomycin B Leptomycin B Binding Regulation Of Transcription By RNA Polymerase II Pigment Cell Development Protein-N-terminal Glutamine Amidohydrolase Activity Regulation Of Natural Killer Cell Apoptotic Process	Vesicle-mediated Transport To The Plasma Membrane Post-Golgi Vesicle-mediated Transport Iron-sulfur Cluster Assembly Complex [2Fe-2S] Cluster Assembly Iron-sulfur Cluster Assembly 2 Iron, 2 Sulfur Cluster Binding Localization Within Membrane Protein Localization To Cell Periphery Cell Redox Homeostasis Golgi Vesicle Transport Embryonic Ectodermal Digestive Tract Development Synaptic Vesicle Recycling Via Endosome Protein Localization To Membrane Mitotic DNA Replication Preinitiation Complex Assembly Golgi To Plasma Membrane Transport Intracellular Iron Ion Homeostasis Iron-sulfur Cluster Binding Endocytic Recycling Negative Regulation Of Intralumenal Vesicle Formation Membrane Docking Epidermal Growth Factor Catabolic Process Intracellular Monoatomic Ion Homeostasis Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Intracellular Monoatomic Cation Homeostasis DNA Replication Preinitiation Complex Retrograde Transport, Endosome To Golgi Protein Transport Monoatomic Cation Homeostasis Lipophagy DNA Replication Preinitiation Complex Assembly Monoatomic Ion Homeostasis Lysosomal Transport Cytosolic Transport Vesicle-mediated Transport Negative Regulation Of Exosomal Secretion Intracellular Chemical Homeostasis Recycling Endosome GARP Complex EARP Complex Ectodermal Cell Differentiation Protein To Membrane Docking Glutamatergic Synapse Regulation Of Endosome Organization Membrane Fusion Establishment Of Protein Localization Alveolar Lamellar Body Vacuolar Transport Cellular Homeostasis Phagosome Acidification Membrane Organization
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