SLC6A3 and AHRR

		SLC6A3	AHRR
Description		solute carrier family 6 member 3	aryl hydrocarbon receptor repressor
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Surface Membrane Flotillin Complex Axon Presynaptic Membrane Cell Projection Neuron Projection Neuronal Cell Body Axon Terminus Membrane Raft Postsynaptic Membrane Dopaminergic Synapse	Chromatin Nucleus Nucleoplasm Cytoplasm Aryl Hydrocarbon Receptor Complex
	Molecular Function	Protease Binding Signaling Receptor Binding Neurotransmitter Transmembrane Transporter Activity Dopamine:sodium Symporter Activity Norepinephrine:sodium Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Symporter Activity Transmembrane Transporter Activity Dopamine Binding Amine Binding Protein-containing Complex Binding Metal Ion Binding Protein Phosphatase 2A Binding Heterocyclic Compound Binding	Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Nuclear Receptor Activity Protein Binding Protein Dimerization Activity
	Biological Process	Neurotransmitter Uptake Neurotransmitter Transport Amino Acid Transport Lactation Sensory Perception Of Smell Locomotory Behavior Response To Xenobiotic Stimulus Response To Iron Ion Monoamine Transport Dopamine Transport Adenohypophysis Development Response To Nicotine Sodium Ion Transmembrane Transport Positive Regulation Of Multicellular Organism Growth Regulation Of Dopamine Metabolic Process Response To Cocaine Dopamine Biosynthetic Process Dopamine Catabolic Process Response To Ethanol Cognition Dopamine Uptake Involved In Synaptic Transmission Response To CAMP Norepinephrine Uptake Prepulse Inhibition Dopamine Uptake Hyaloid Vascular Plexus Regression	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Xenobiotic Metabolic Process Response To Xenobiotic Stimulus Intracellular Receptor Signaling Pathway
Pathways		Dopamine clearance from the synaptic cleft SLC-mediated transport of neurotransmitters Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	PPARA activates gene expression Phase I - Functionalization of compounds Endogenous sterols Xenobiotics Aryl hydrocarbon receptor signalling
Drugs		Amphetamine Phentermine Benzatropine Venlafaxine Loxapine Methylphenidate Meperidine Imipramine Duloxetine Amoxapine Mazindol Procaine Trimipramine Modafinil Phenmetrazine Pseudoephedrine Benzphetamine Cocaine Diethylpropion Dopamine Sertraline Sibutramine Chlorpheniramine Diphenylpyraline Nefazodone Bupropion Chloroprocaine Escitalopram Aripiprazole Ephedra sinica root MMDA Midomafetamine Fencamfamin 4-Methoxyamphetamine Dextroamphetamine Metamfetamine Vanoxerine Nomifensine Altropane Mianserin Tesofensine Trodusquemine Armodafinil Desvenlafaxine Dexmethylphenidate Dasotraline Solriamfetol Serdexmethylphenidate
Diseases
GWAS		Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725) Pancreatic cancer ( 25086665)	Breast cancer ( 29059683) Cystic fibrosis severity ( 21602797) Estimated glomerular filtration rate ( 31015462) Fat distribution (HIV) ( 21897333) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 29617998) Systolic blood pressure ( 30224653)
Interacting Genes		9 interacting genes: DRD2 MTNR1A NEDD4 PICK1 RACK1 SNCA SNTA1 STX1A TGFB1I1	1 interacting genes: ARNT
Entrez ID		6531	57491
HPRD ID		00543	07356
Ensembl ID		ENSG00000142319	ENSG00000063438
Uniprot IDs		Q01959	A0A7I2PK40 A9YTQ3
PDB IDs		8VBY 8Y2C 8Y2D 8Y2E 8Y2F 8Y2G 9EO4	5Y7Y
Enriched GO Terms of Interacting Partners?		Regulation Of Membrane Potential Monoamine Transport Regulation Of Catecholamine Secretion Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Transport Regulation Of Sodium Ion Transport Receptor Internalization Regulation Of Vesicle-mediated Transport Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Transport Regulation Of Amine Transport Catecholamine Uptake Dopamine Uptake SNARE Complex Assembly Neurotransmitter Transport Regulation Of Endocytosis Synaptic Transmission, Dopaminergic Behavioral Response To Cocaine Regulation Of Metal Ion Transport Presynaptic Membrane Dopamine Transport Neurotransmitter Reuptake Synaptic Vesicle Membrane Regulation Of Neurotransmitter Uptake Positive Regulation Of Neurotransmitter Secretion Synaptic Vesicle Transmembrane Transporter Binding Positive Regulation Of Synaptic Transmission Regulation Of Dopamine Secretion Regulation Of Monoatomic Ion Transport Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Transport Regulation Of Protein Transport Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Endocytosis Endocytosis Regulation Of Insulin Secretion Regulation Of Protein Localization Positive Regulation Of Receptor Internalization Neurotransmitter Uptake Receptor-mediated Endocytosis Dopamine Metabolic Process Ionotropic Glutamate Receptor Binding Response To Iron Ion Modulation Of Chemical Synaptic Transmission Synaptic Vesicle Exocytosis Ribosome Regulation Of Peptide Hormone Secretion Regulation Of Synaptic Plasticity Regulation Of Establishment Of Protein Localization	Membrane Raft Response To Alcohol Nuclear Aryl Hydrocarbon Receptor Complex Positive Regulation Of Hormone Biosynthetic Process Aryl Hydrocarbon Receptor Binding Aryl Hydrocarbon Receptor Complex Intestinal Epithelial Structure Maintenance Hyaloid Vascular Plexus Regression Norepinephrine Uptake Dopamine Uptake Involved In Synaptic Transmission Catecholamine Catabolic Process Amine Binding Heterocyclic Compound Binding Monoamine Transmembrane Transporter Activity Norepinephrine:sodium Symporter Activity Dopamine Binding Norepinephrine Transport Dopamine Biosynthetic Process Dopamine:sodium Symporter Activity Adenohypophysis Development Dopamine Catabolic Process Flotillin Complex CAMP Biosynthetic Process Adenylate Cyclase Activity Catecholamine Uptake Dopamine Uptake Adenylate Cyclase Binding Positive Regulation Of Protein Sumoylation Dopaminergic Synapse Prepulse Inhibition Anatomical Structure Regression Cellular Response To Forskolin Phosphorus-oxygen Lyase Activity CAMP Metabolic Process Response To Forskolin Cyclic Nucleotide Biosynthetic Process Regulation Of Hormone Biosynthetic Process Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Glycolytic Process Regulation Of Protein Sumoylation Maintenance Of Gastrointestinal Epithelium Regulation Of Dopamine Metabolic Process Dopamine Transport Neurotransmitter Reuptake Catecholamine Biosynthetic Process Neurotransmitter Transmembrane Transporter Activity Embryonic Placenta Development Protein Phosphatase 2A Binding Monoamine Transport Neurotransmitter Uptake
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