AHRR

Description		aryl hydrocarbon receptor repressor
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Aryl Hydrocarbon Receptor Complex
	Molecular Function	Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Nuclear Receptor Activity Protein Binding Protein Dimerization Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Xenobiotic Metabolic Process Response To Xenobiotic Stimulus Intracellular Receptor Signaling Pathway
Pathways		PPARA activates gene expression Phase I - Functionalization of compounds Endogenous sterols Xenobiotics Aryl hydrocarbon receptor signalling
Drugs
Diseases
GWAS		Breast cancer ( 29059683) Cystic fibrosis severity ( 21602797) Estimated glomerular filtration rate ( 31015462) Fat distribution (HIV) ( 21897333) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 29617998) Systolic blood pressure ( 30224653)
Novel Interacting Genes		2 novel interacting genes: ADCY2 SLC6A3
Interacting Genes		1 interacting genes: ARNT
Entrez ID		57491
HPRD ID		07356
Ensembl ID		ENSG00000063438
Uniprot IDs		A0A7I2PK40 A9YTQ3
PDB IDs		5Y7Y
Enriched GO Terms of Interacting Partners?		Membrane Raft Response To Alcohol Nuclear Aryl Hydrocarbon Receptor Complex Positive Regulation Of Hormone Biosynthetic Process Aryl Hydrocarbon Receptor Binding Aryl Hydrocarbon Receptor Complex Intestinal Epithelial Structure Maintenance Hyaloid Vascular Plexus Regression Norepinephrine Uptake Dopamine Uptake Involved In Synaptic Transmission Catecholamine Catabolic Process Amine Binding Heterocyclic Compound Binding Monoamine Transmembrane Transporter Activity Norepinephrine:sodium Symporter Activity Dopamine Binding Norepinephrine Transport Dopamine Biosynthetic Process Dopamine:sodium Symporter Activity Adenohypophysis Development Dopamine Catabolic Process Flotillin Complex CAMP Biosynthetic Process Adenylate Cyclase Activity Catecholamine Uptake Dopamine Uptake Adenylate Cyclase Binding Positive Regulation Of Protein Sumoylation Dopaminergic Synapse Prepulse Inhibition Anatomical Structure Regression Cellular Response To Forskolin Phosphorus-oxygen Lyase Activity CAMP Metabolic Process Response To Forskolin Cyclic Nucleotide Biosynthetic Process Regulation Of Hormone Biosynthetic Process Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Glycolytic Process Regulation Of Protein Sumoylation Maintenance Of Gastrointestinal Epithelium Regulation Of Dopamine Metabolic Process Dopamine Transport Neurotransmitter Reuptake Catecholamine Biosynthetic Process Neurotransmitter Transmembrane Transporter Activity Embryonic Placenta Development Protein Phosphatase 2A Binding Monoamine Transport Neurotransmitter Uptake
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